Interactions of Insoluble Residue from Enzymatic Hydrolysis of Brewer's Spent Grain with Intestinal Microbiota in Mice

Johanna Maukonen, Anna Marja Aura, Piritta Niemi, Gulam Shere Raza, Klaus Niemelä, Jaroslaw Walkowiak, Ismo Mattila, Kaisa Poutanen, Johanna Buchert, Karl Heinz Herzig

Research output: Contribution to journalArticleScientificpeer-review

3 Citations (Scopus)

Abstract

Brewer's spent grain (BSG) is the major side-stream from brewing. As BSG is rich in dietary fiber and protein, it could be used in more valuable applications, such as nutritional additives for foods. Our aim was to elucidate whether an insoluble lignin-rich fraction (INS) from BSG is metabolized by mice gut microbiota and how it affects the microbiota. Our results indicated that lignin was partially degraded by the gut microbiota, degradation products were absorbed, and finally excreted in urine. Therefore, they contribute to the phenolic pool circulating in the mammalian body, and may have systemic effects on health. In addition, the effects of the test diets on the microbiota were significant. Most interestingly, diversities of predominant cecal and fecal bacteria were higher after the intervention diet containing INS than after the intervention diet containing cellulose. Since low fecal bacterial diversity has been linked with numerous diseases and disorders, the diversity increasing ability opens very interesting perspectives for the future.

Original languageEnglish
Pages (from-to)3748-3756
Number of pages9
JournalJournal of Agricultural and Food Chemistry
Volume65
Issue number18
DOIs
Publication statusPublished - 10 May 2017
MoE publication typeA1 Journal article-refereed

Fingerprint

spent grains
brewers grains
Enzymatic hydrolysis
enzymatic hydrolysis
Nutrition
intestinal microorganisms
Hydrolysis
Lignin
Microbiota
Diet
lignin
mice
Brewing
Food Additives
Dietary Proteins
brewing
Dietary Fiber
food additives
Cellulose
diet

Keywords

  • brewer's spent grain
  • cecal mouse microbiota
  • dietary fiber
  • fecal mouse microbiota
  • lignin
  • urinary metabolites

Cite this

Maukonen, Johanna ; Aura, Anna Marja ; Niemi, Piritta ; Raza, Gulam Shere ; Niemelä, Klaus ; Walkowiak, Jaroslaw ; Mattila, Ismo ; Poutanen, Kaisa ; Buchert, Johanna ; Herzig, Karl Heinz. / Interactions of Insoluble Residue from Enzymatic Hydrolysis of Brewer's Spent Grain with Intestinal Microbiota in Mice. In: Journal of Agricultural and Food Chemistry. 2017 ; Vol. 65, No. 18. pp. 3748-3756.
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abstract = "Brewer's spent grain (BSG) is the major side-stream from brewing. As BSG is rich in dietary fiber and protein, it could be used in more valuable applications, such as nutritional additives for foods. Our aim was to elucidate whether an insoluble lignin-rich fraction (INS) from BSG is metabolized by mice gut microbiota and how it affects the microbiota. Our results indicated that lignin was partially degraded by the gut microbiota, degradation products were absorbed, and finally excreted in urine. Therefore, they contribute to the phenolic pool circulating in the mammalian body, and may have systemic effects on health. In addition, the effects of the test diets on the microbiota were significant. Most interestingly, diversities of predominant cecal and fecal bacteria were higher after the intervention diet containing INS than after the intervention diet containing cellulose. Since low fecal bacterial diversity has been linked with numerous diseases and disorders, the diversity increasing ability opens very interesting perspectives for the future.",
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Interactions of Insoluble Residue from Enzymatic Hydrolysis of Brewer's Spent Grain with Intestinal Microbiota in Mice. / Maukonen, Johanna; Aura, Anna Marja; Niemi, Piritta; Raza, Gulam Shere; Niemelä, Klaus; Walkowiak, Jaroslaw; Mattila, Ismo; Poutanen, Kaisa; Buchert, Johanna; Herzig, Karl Heinz.

In: Journal of Agricultural and Food Chemistry, Vol. 65, No. 18, 10.05.2017, p. 3748-3756.

Research output: Contribution to journalArticleScientificpeer-review

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AU - Raza, Gulam Shere

AU - Niemelä, Klaus

AU - Walkowiak, Jaroslaw

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AU - Buchert, Johanna

AU - Herzig, Karl Heinz

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