Interfacial Membranization of Regenerated Cellulose Nanoparticles and a Protein Renders Stable Water-in-Water Emulsion

Ya Zhu; Marco Beaumont; Katariina Solin; Panagiotis Spiliopoulos; Bin Zhao; Han Tao; Eero Kontturi; Long Bai; Orlando Rojas

doi:10.1002/smll.202400952

Interfacial Membranization of Regenerated Cellulose Nanoparticles and a Protein Renders Stable Water-in-Water Emulsion

Ya Zhu, Marco Beaumont^*, Katariina Solin, Panagiotis Spiliopoulos, Bin Zhao, Han Tao, Eero Kontturi, Long Bai^*, Orlando Rojas^*

^*Corresponding author for this work

BA5407 Bioinspired materials

Research output: Contribution to journal › Article › Scientific › peer-review

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Abstract

Pickering water-in-water (W/W) emulsions stabilized by biobased colloids are pertinent to engineering biomaterials with hierarchical and confined architectures. In this study, stable W/W emulsions are developed through membranization utilizing biopolymer structures formed by the adsorption of cellulose II nanospheres and a globular protein, bovine serum albumin (BSA), at droplet surfaces. The produced cellulose II nanospheres (NPcat, 63 nm diameter) bearing a soft and highly accessible shell, endow rapid and significant binding (16 mg cm−2) with BSA. NPcat and BSA formed complexes that spontaneously stabilized liquid droplets, resulting in stable W/W emulsions. It is proposed that such a system is a versatile all-aqueous platform for encapsulation, (bio)catalysis, delivery, and synthetic cell mimetics.

Original language	English
Article number	2400952
Journal	Small
Volume	20
Issue number	44
DOIs	https://doi.org/10.1002/smll.202400952
Publication status	Published - 16 Jul 2024
MoE publication type	A1 Journal article-refereed

Keywords

aqueous two-phase systems
membranization
regenerated cellulose nanospheres
water-in-water emulsion

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title = "Interfacial Membranization of Regenerated Cellulose Nanoparticles and a Protein Renders Stable Water-in-Water Emulsion",

abstract = "Pickering water-in-water (W/W) emulsions stabilized by biobased colloids are pertinent to engineering biomaterials with hierarchical and confined architectures. In this study, stable W/W emulsions are developed through membranization utilizing biopolymer structures formed by the adsorption of cellulose II nanospheres and a globular protein, bovine serum albumin (BSA), at droplet surfaces. The produced cellulose II nanospheres (NPcat, 63 nm diameter) bearing a soft and highly accessible shell, endow rapid and significant binding (16 mg cm−2) with BSA. NPcat and BSA formed complexes that spontaneously stabilized liquid droplets, resulting in stable W/W emulsions. It is proposed that such a system is a versatile all-aqueous platform for encapsulation, (bio)catalysis, delivery, and synthetic cell mimetics.",

keywords = "aqueous two-phase systems, membranization, regenerated cellulose nanospheres, water-in-water emulsion",

author = "Ya Zhu and Marco Beaumont and Katariina Solin and Panagiotis Spiliopoulos and Bin Zhao and Han Tao and Eero Kontturi and Long Bai and Orlando Rojas",

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T1 - Interfacial Membranization of Regenerated Cellulose Nanoparticles and a Protein Renders Stable Water-in-Water Emulsion

AU - Zhu, Ya

AU - Beaumont, Marco

AU - Solin, Katariina

AU - Spiliopoulos, Panagiotis

AU - Zhao, Bin

AU - Tao, Han

AU - Kontturi, Eero

AU - Bai, Long

AU - Rojas, Orlando

PY - 2024/7/16

Y1 - 2024/7/16

N2 - Pickering water-in-water (W/W) emulsions stabilized by biobased colloids are pertinent to engineering biomaterials with hierarchical and confined architectures. In this study, stable W/W emulsions are developed through membranization utilizing biopolymer structures formed by the adsorption of cellulose II nanospheres and a globular protein, bovine serum albumin (BSA), at droplet surfaces. The produced cellulose II nanospheres (NPcat, 63 nm diameter) bearing a soft and highly accessible shell, endow rapid and significant binding (16 mg cm−2) with BSA. NPcat and BSA formed complexes that spontaneously stabilized liquid droplets, resulting in stable W/W emulsions. It is proposed that such a system is a versatile all-aqueous platform for encapsulation, (bio)catalysis, delivery, and synthetic cell mimetics.

AB - Pickering water-in-water (W/W) emulsions stabilized by biobased colloids are pertinent to engineering biomaterials with hierarchical and confined architectures. In this study, stable W/W emulsions are developed through membranization utilizing biopolymer structures formed by the adsorption of cellulose II nanospheres and a globular protein, bovine serum albumin (BSA), at droplet surfaces. The produced cellulose II nanospheres (NPcat, 63 nm diameter) bearing a soft and highly accessible shell, endow rapid and significant binding (16 mg cm−2) with BSA. NPcat and BSA formed complexes that spontaneously stabilized liquid droplets, resulting in stable W/W emulsions. It is proposed that such a system is a versatile all-aqueous platform for encapsulation, (bio)catalysis, delivery, and synthetic cell mimetics.

KW - aqueous two-phase systems

KW - membranization

KW - regenerated cellulose nanospheres

KW - water-in-water emulsion

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DO - 10.1002/smll.202400952

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Interfacial Membranization of Regenerated Cellulose Nanoparticles and a Protein Renders Stable Water-in-Water Emulsion

Abstract

Keywords

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