Interhemispheric differences of electroencephalography signal characteristics in different sleep stages

Masoumeh Tashakori; Matias Rusanen; Tuomas Karhu; Ludger Grote; Rajdeep Kumar Nath; Timo Leppänen; Sami Nikkonen

doi:10.1016/j.sleep.2024.03.024

Interhemispheric differences of electroencephalography signal characteristics in different sleep stages

Masoumeh Tashakori^*
, Matias Rusanen
, Tuomas Karhu
, Ludger Grote
, Rajdeep Kumar Nath
, Timo Leppänen
, Sami Nikkonen

^*Corresponding author for this work

BA6307 Human sensing solutions

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4 Citations (Scopus)

Abstract

Objective: The current electroencephalography (EEG) measurement setup is complex, laborious to set up, and uncomfortable for patients. We hypothesize that differences in EEG signal characteristics for sleep staging between the left and right hemispheres are negligible; therefore, there is potential to simplify the current measurement setup. We aimed to investigate the technical hemispheric differences in EEG signal characteristics along with electrooculography (EOG) signals during different sleep stages. Methods: Type II portable polysomnography (PSG) recordings of 50 patients were studied. Amplitudes and power spectral densities (PSDs) of the EEG and EOG signals were compared between the left (C3-M2, F3-M2, O1-M2, and E1-M2) and the right (C4-M1, F4-M1, O2-M1, and E2-M2) hemispheres. Regression analysis was performed to investigate the potential influence of sleep stages on the hemispheric differences in PSDs. Wilcoxon signed-rank tests were also employed to calculate the effect size of hemispheres across different frequency bands and sleep stages. Results: The results showed statistically significant differences in signal characteristics between hemispheres, but the absolute differences were minor. The median hemispheric differences in amplitudes were smaller than 3 μv with large interquartile ranges during all sleep stages. The absolute and relative PSD characteristics were highly similar between hemispheres in different sleep stages. Additionally, there were negligible differences in the effect size between hemispheres across all sleep stages. Conclusions: Technical signal differences between hemispheres were minor across all sleep stages, indicating that both hemispheres contain similar information needed for sleep staging. A reduced measurement setup could be suitable for sleep staging without the loss of relevant information.

Original language	English
Pages (from-to)	201-208
Journal	Sleep Medicine
Volume	117
DOIs	https://doi.org/10.1016/j.sleep.2024.03.024
Publication status	Published - May 2024
MoE publication type	A1 Journal article-refereed

Funding

The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Timo Leppänen reports financial support was provided by European Union's Horizon 2020 Research and Innovation programme (965417), NordForsk (90458) via Business Finland (5133/31/2018), and Research Committee of the Kuopio University Hospital Catchment Area for the State Research Funding (5041794). Sami Nikkonen reports financial support was provided by Research Committee of the Kuopio University Hospital Catchment Area for the State Research Funding (5041809), European Union's Horizon 2020 Research and Innovation Programme (965417), and Finnish Cultural Foundation. Matias Rusanen reports financial support was provided by Research Committee of the Kuopio University Hospital Catchment Area for the State Research Funding (5041807), Finnish Cultural Foundation through Kainuu regional fund, the Research Committee of Kuopio University Hospital Catchment Area for the State Research Funding (5041797), and National Research Agency, framework of the Investissements MIAI Artificial Intelligence chairs of excellence from the Grenoble Alpes (ANR-15-IDEX-02 and ANR-19-P3IA-0003). Tuomas Karhu reports financial support was provided by NordForsk (90458) via Business Finland (5133/31/2018). Masoumeh Tashakori reports financial support was provided by Kuopio Area Respiratory Foundation. None of the authors have potential conflicts of interest to be disclosed. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. This study was funded by the European Union's Horizon 2020 Research and Innovation programme ( 965417 ), NordForsk (90458) via Business Finland ( 5133/31/2018 ), Research Committee of the Kuopio University Hospital Catchment Area for the State Research Funding (projects 5041794 , 5041809 , and 5041807 ), Kuopio Area Respiratory Foundation , Finnish Cultural Foundation through Kainuu regional fund.

Keywords

Electroencephalography (EEG)
Hemispheric differences
Sleep staging

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10.1016/j.sleep.2024.03.024Licence: CC BY

Cite this

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title = "Interhemispheric differences of electroencephalography signal characteristics in different sleep stages",

abstract = "Objective: The current electroencephalography (EEG) measurement setup is complex, laborious to set up, and uncomfortable for patients. We hypothesize that differences in EEG signal characteristics for sleep staging between the left and right hemispheres are negligible; therefore, there is potential to simplify the current measurement setup. We aimed to investigate the technical hemispheric differences in EEG signal characteristics along with electrooculography (EOG) signals during different sleep stages. Methods: Type II portable polysomnography (PSG) recordings of 50 patients were studied. Amplitudes and power spectral densities (PSDs) of the EEG and EOG signals were compared between the left (C3-M2, F3-M2, O1-M2, and E1-M2) and the right (C4-M1, F4-M1, O2-M1, and E2-M2) hemispheres. Regression analysis was performed to investigate the potential influence of sleep stages on the hemispheric differences in PSDs. Wilcoxon signed-rank tests were also employed to calculate the effect size of hemispheres across different frequency bands and sleep stages. Results: The results showed statistically significant differences in signal characteristics between hemispheres, but the absolute differences were minor. The median hemispheric differences in amplitudes were smaller than 3 μv with large interquartile ranges during all sleep stages. The absolute and relative PSD characteristics were highly similar between hemispheres in different sleep stages. Additionally, there were negligible differences in the effect size between hemispheres across all sleep stages. Conclusions: Technical signal differences between hemispheres were minor across all sleep stages, indicating that both hemispheres contain similar information needed for sleep staging. A reduced measurement setup could be suitable for sleep staging without the loss of relevant information.",

keywords = "Electroencephalography (EEG), Hemispheric differences, Sleep staging",

author = "Masoumeh Tashakori and Matias Rusanen and Tuomas Karhu and Ludger Grote and Nath, \{Rajdeep Kumar\} and Timo Lepp{\"a}nen and Sami Nikkonen",

note = "Publisher Copyright: {\textcopyright} 2024 The Authors",

year = "2024",

month = may,

doi = "10.1016/j.sleep.2024.03.024",

language = "English",

volume = "117",

pages = "201--208",

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AU - Tashakori, Masoumeh

AU - Rusanen, Matias

AU - Karhu, Tuomas

AU - Grote, Ludger

AU - Nath, Rajdeep Kumar

AU - Leppänen, Timo

AU - Nikkonen, Sami

PY - 2024/5

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N2 - Objective: The current electroencephalography (EEG) measurement setup is complex, laborious to set up, and uncomfortable for patients. We hypothesize that differences in EEG signal characteristics for sleep staging between the left and right hemispheres are negligible; therefore, there is potential to simplify the current measurement setup. We aimed to investigate the technical hemispheric differences in EEG signal characteristics along with electrooculography (EOG) signals during different sleep stages. Methods: Type II portable polysomnography (PSG) recordings of 50 patients were studied. Amplitudes and power spectral densities (PSDs) of the EEG and EOG signals were compared between the left (C3-M2, F3-M2, O1-M2, and E1-M2) and the right (C4-M1, F4-M1, O2-M1, and E2-M2) hemispheres. Regression analysis was performed to investigate the potential influence of sleep stages on the hemispheric differences in PSDs. Wilcoxon signed-rank tests were also employed to calculate the effect size of hemispheres across different frequency bands and sleep stages. Results: The results showed statistically significant differences in signal characteristics between hemispheres, but the absolute differences were minor. The median hemispheric differences in amplitudes were smaller than 3 μv with large interquartile ranges during all sleep stages. The absolute and relative PSD characteristics were highly similar between hemispheres in different sleep stages. Additionally, there were negligible differences in the effect size between hemispheres across all sleep stages. Conclusions: Technical signal differences between hemispheres were minor across all sleep stages, indicating that both hemispheres contain similar information needed for sleep staging. A reduced measurement setup could be suitable for sleep staging without the loss of relevant information.

AB - Objective: The current electroencephalography (EEG) measurement setup is complex, laborious to set up, and uncomfortable for patients. We hypothesize that differences in EEG signal characteristics for sleep staging between the left and right hemispheres are negligible; therefore, there is potential to simplify the current measurement setup. We aimed to investigate the technical hemispheric differences in EEG signal characteristics along with electrooculography (EOG) signals during different sleep stages. Methods: Type II portable polysomnography (PSG) recordings of 50 patients were studied. Amplitudes and power spectral densities (PSDs) of the EEG and EOG signals were compared between the left (C3-M2, F3-M2, O1-M2, and E1-M2) and the right (C4-M1, F4-M1, O2-M1, and E2-M2) hemispheres. Regression analysis was performed to investigate the potential influence of sleep stages on the hemispheric differences in PSDs. Wilcoxon signed-rank tests were also employed to calculate the effect size of hemispheres across different frequency bands and sleep stages. Results: The results showed statistically significant differences in signal characteristics between hemispheres, but the absolute differences were minor. The median hemispheric differences in amplitudes were smaller than 3 μv with large interquartile ranges during all sleep stages. The absolute and relative PSD characteristics were highly similar between hemispheres in different sleep stages. Additionally, there were negligible differences in the effect size between hemispheres across all sleep stages. Conclusions: Technical signal differences between hemispheres were minor across all sleep stages, indicating that both hemispheres contain similar information needed for sleep staging. A reduced measurement setup could be suitable for sleep staging without the loss of relevant information.

KW - Electroencephalography (EEG)

KW - Hemispheric differences

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DO - 10.1016/j.sleep.2024.03.024

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SP - 201

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JO - Sleep Medicine

JF - Sleep Medicine

ER -

Interhemispheric differences of electroencephalography signal characteristics in different sleep stages

Abstract

Funding

Keywords

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