Interlaboratory coverage test on plant food bioactive compounds and their metabolites by mass spectrometry-based untargeted metabolomics

Ville Mikael Koistinen (Corresponding Author), Andreia Bento da Silva, László Abrankó, Dorrain Low, Rocio Garcia Villalba, Francisco Tomás Barberán, Rikard Landberg, Otto Savolainen, Inmaculada Alvarez-Acero, Sonia de Pascual-Teresa, Christof Van Poucke, Conceição Almeida, Lucie Petrásková, Kateřina Valentová, Stephanie Durand, Wiesław Wiczkowski, Dorota Szawara-Nowak, Raúl González-Domínguez, Rafael Llorach, Cristina Andrés-LacuevaAnna Marja Aura, Tuulikki Seppänen-Laakso, Kati Hanhineva, Claudine Manach, Maria Rosário Bronze

Research output: Contribution to journalArticleScientificpeer-review

2 Citations (Scopus)

Abstract

Bioactive compounds present in plant-based foods, and their metabolites derived from gut microbiota and endogenous metabolism, represent thousands of chemical structures of potential interest for human nutrition and health. State-of-the-art analytical methodologies, including untargeted metabolomics based on high-resolution mass spectrometry, are required for the profiling of these compounds in complex matrices, including plant food materials and biofluids. The aim of this project was to compare the analytical coverage of untargeted metabolomics methods independently developed and employed in various European platforms. In total, 56 chemical standards representing the most common classes of bioactive compounds spread over a wide chemical space were selected and analyzed by the participating platforms (n = 13) using their preferred untargeted method. The results were used to define analytical criteria for a successful analysis of plant food bioactives. Furthermore, they will serve as a basis for an optimized consensus method.

Original languageEnglish
Article number46
JournalMetabolites
Volume8
Issue number3
DOIs
Publication statusPublished - 1 Sep 2018
MoE publication typeNot Eligible

Fingerprint

Edible Plants
Metabolomics
Metabolites
Mass spectrometry
Mass Spectrometry
Food Analysis
Nutrition
Metabolism
Health

Keywords

  • Mass spectrometry
  • Method development
  • Phytochemicals

Cite this

Koistinen, V. M., da Silva, A. B., Abrankó, L., Low, D., Villalba, R. G., Barberán, F. T., ... Bronze, M. R. (2018). Interlaboratory coverage test on plant food bioactive compounds and their metabolites by mass spectrometry-based untargeted metabolomics. Metabolites, 8(3), [46]. https://doi.org/10.3390/metabo8030046
Koistinen, Ville Mikael ; da Silva, Andreia Bento ; Abrankó, László ; Low, Dorrain ; Villalba, Rocio Garcia ; Barberán, Francisco Tomás ; Landberg, Rikard ; Savolainen, Otto ; Alvarez-Acero, Inmaculada ; de Pascual-Teresa, Sonia ; Van Poucke, Christof ; Almeida, Conceição ; Petrásková, Lucie ; Valentová, Kateřina ; Durand, Stephanie ; Wiczkowski, Wiesław ; Szawara-Nowak, Dorota ; González-Domínguez, Raúl ; Llorach, Rafael ; Andrés-Lacueva, Cristina ; Aura, Anna Marja ; Seppänen-Laakso, Tuulikki ; Hanhineva, Kati ; Manach, Claudine ; Bronze, Maria Rosário. / Interlaboratory coverage test on plant food bioactive compounds and their metabolites by mass spectrometry-based untargeted metabolomics. In: Metabolites. 2018 ; Vol. 8, No. 3.
@article{9221972ec1ea4fc08b3ccadec4fd3963,
title = "Interlaboratory coverage test on plant food bioactive compounds and their metabolites by mass spectrometry-based untargeted metabolomics",
abstract = "Bioactive compounds present in plant-based foods, and their metabolites derived from gut microbiota and endogenous metabolism, represent thousands of chemical structures of potential interest for human nutrition and health. State-of-the-art analytical methodologies, including untargeted metabolomics based on high-resolution mass spectrometry, are required for the profiling of these compounds in complex matrices, including plant food materials and biofluids. The aim of this project was to compare the analytical coverage of untargeted metabolomics methods independently developed and employed in various European platforms. In total, 56 chemical standards representing the most common classes of bioactive compounds spread over a wide chemical space were selected and analyzed by the participating platforms (n = 13) using their preferred untargeted method. The results were used to define analytical criteria for a successful analysis of plant food bioactives. Furthermore, they will serve as a basis for an optimized consensus method.",
keywords = "Mass spectrometry, Method development, Phytochemicals",
author = "Koistinen, {Ville Mikael} and {da Silva}, {Andreia Bento} and L{\'a}szl{\'o} Abrank{\'o} and Dorrain Low and Villalba, {Rocio Garcia} and Barber{\'a}n, {Francisco Tom{\'a}s} and Rikard Landberg and Otto Savolainen and Inmaculada Alvarez-Acero and {de Pascual-Teresa}, Sonia and {Van Poucke}, Christof and Concei{\cc}{\~a}o Almeida and Lucie Petr{\'a}skov{\'a} and Kateřina Valentov{\'a} and Stephanie Durand and Wiesław Wiczkowski and Dorota Szawara-Nowak and Ra{\'u}l Gonz{\'a}lez-Dom{\'i}nguez and Rafael Llorach and Cristina Andr{\'e}s-Lacueva and Aura, {Anna Marja} and Tuulikki Sepp{\"a}nen-Laakso and Kati Hanhineva and Claudine Manach and Bronze, {Maria Ros{\'a}rio}",
year = "2018",
month = "9",
day = "1",
doi = "10.3390/metabo8030046",
language = "English",
volume = "8",
journal = "Metabolites",
issn = "2218-1989",
publisher = "MDPI",
number = "3",

}

Koistinen, VM, da Silva, AB, Abrankó, L, Low, D, Villalba, RG, Barberán, FT, Landberg, R, Savolainen, O, Alvarez-Acero, I, de Pascual-Teresa, S, Van Poucke, C, Almeida, C, Petrásková, L, Valentová, K, Durand, S, Wiczkowski, W, Szawara-Nowak, D, González-Domínguez, R, Llorach, R, Andrés-Lacueva, C, Aura, AM, Seppänen-Laakso, T, Hanhineva, K, Manach, C & Bronze, MR 2018, 'Interlaboratory coverage test on plant food bioactive compounds and their metabolites by mass spectrometry-based untargeted metabolomics', Metabolites, vol. 8, no. 3, 46. https://doi.org/10.3390/metabo8030046

Interlaboratory coverage test on plant food bioactive compounds and their metabolites by mass spectrometry-based untargeted metabolomics. / Koistinen, Ville Mikael (Corresponding Author); da Silva, Andreia Bento; Abrankó, László; Low, Dorrain; Villalba, Rocio Garcia; Barberán, Francisco Tomás; Landberg, Rikard; Savolainen, Otto; Alvarez-Acero, Inmaculada; de Pascual-Teresa, Sonia; Van Poucke, Christof; Almeida, Conceição; Petrásková, Lucie; Valentová, Kateřina; Durand, Stephanie; Wiczkowski, Wiesław; Szawara-Nowak, Dorota; González-Domínguez, Raúl; Llorach, Rafael; Andrés-Lacueva, Cristina; Aura, Anna Marja; Seppänen-Laakso, Tuulikki; Hanhineva, Kati; Manach, Claudine; Bronze, Maria Rosário.

In: Metabolites, Vol. 8, No. 3, 46, 01.09.2018.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Interlaboratory coverage test on plant food bioactive compounds and their metabolites by mass spectrometry-based untargeted metabolomics

AU - Koistinen, Ville Mikael

AU - da Silva, Andreia Bento

AU - Abrankó, László

AU - Low, Dorrain

AU - Villalba, Rocio Garcia

AU - Barberán, Francisco Tomás

AU - Landberg, Rikard

AU - Savolainen, Otto

AU - Alvarez-Acero, Inmaculada

AU - de Pascual-Teresa, Sonia

AU - Van Poucke, Christof

AU - Almeida, Conceição

AU - Petrásková, Lucie

AU - Valentová, Kateřina

AU - Durand, Stephanie

AU - Wiczkowski, Wiesław

AU - Szawara-Nowak, Dorota

AU - González-Domínguez, Raúl

AU - Llorach, Rafael

AU - Andrés-Lacueva, Cristina

AU - Aura, Anna Marja

AU - Seppänen-Laakso, Tuulikki

AU - Hanhineva, Kati

AU - Manach, Claudine

AU - Bronze, Maria Rosário

PY - 2018/9/1

Y1 - 2018/9/1

N2 - Bioactive compounds present in plant-based foods, and their metabolites derived from gut microbiota and endogenous metabolism, represent thousands of chemical structures of potential interest for human nutrition and health. State-of-the-art analytical methodologies, including untargeted metabolomics based on high-resolution mass spectrometry, are required for the profiling of these compounds in complex matrices, including plant food materials and biofluids. The aim of this project was to compare the analytical coverage of untargeted metabolomics methods independently developed and employed in various European platforms. In total, 56 chemical standards representing the most common classes of bioactive compounds spread over a wide chemical space were selected and analyzed by the participating platforms (n = 13) using their preferred untargeted method. The results were used to define analytical criteria for a successful analysis of plant food bioactives. Furthermore, they will serve as a basis for an optimized consensus method.

AB - Bioactive compounds present in plant-based foods, and their metabolites derived from gut microbiota and endogenous metabolism, represent thousands of chemical structures of potential interest for human nutrition and health. State-of-the-art analytical methodologies, including untargeted metabolomics based on high-resolution mass spectrometry, are required for the profiling of these compounds in complex matrices, including plant food materials and biofluids. The aim of this project was to compare the analytical coverage of untargeted metabolomics methods independently developed and employed in various European platforms. In total, 56 chemical standards representing the most common classes of bioactive compounds spread over a wide chemical space were selected and analyzed by the participating platforms (n = 13) using their preferred untargeted method. The results were used to define analytical criteria for a successful analysis of plant food bioactives. Furthermore, they will serve as a basis for an optimized consensus method.

KW - Mass spectrometry

KW - Method development

KW - Phytochemicals

UR - http://www.scopus.com/inward/record.url?scp=85053035190&partnerID=8YFLogxK

U2 - 10.3390/metabo8030046

DO - 10.3390/metabo8030046

M3 - Article

AN - SCOPUS:85053035190

VL - 8

JO - Metabolites

JF - Metabolites

SN - 2218-1989

IS - 3

M1 - 46

ER -