Interleukin 10 and Heart Fatty Acid-Binding Protein as Early Outcome Predictors in Patients With Traumatic Brain Injury

Linnéa Lagerstedt, Leire Azurmendi, Olli Tenovuo, Ari J. Katila, Riikka S.K. Takala, Kaj Blennow, Virginia F.J. Newcombe, Henna Riikka Maanpää, Jussi Tallus, Iftakher Hossain, Mark van Gils, David K. Menon, Peter J. Hutchinson, Henrik Zetterberg, Jussi P. Posti, Jean Charles Sanchez (Corresponding Author)

Research output: Contribution to journalArticleScientificpeer-review

2 Downloads (Pure)

Abstract

Background: Patients with traumatic brain injury (TBI) exhibit a variable and unpredictable outcome. The proteins interleukin 10 (IL-10) and heart fatty acid-binding protein (H-FABP) have shown predictive values for the presence of intracranial lesions. Aim: To evaluate the individual and combined outcome prediction ability of IL-10 and H-FABP, and to compare them to the more studied proteins S100β, glial fibrillary acidic protein (GFAP), and neurofilament light (NF-L), both with and without clinical predictors. Methods: Blood samples from patients with acute TBI (all severities) were collected <24 h post trauma. The outcome was measured >6 months post injury using the Glasgow Outcome Scale Extended (GOSE) score, dichotomizing patients into: (i) those with favorable (GOSE≥5)/unfavorable outcome (GOSE ≤ 4) and complete (GOSE = 8)/incomplete (GOSE ≤ 7) recovery, and (ii) patients with mild TBI (mTBI) and patients with TBIs of all severities. Results: When sensitivity was set at 95–100%, the proteins' individual specificities remained low. H-FABP showed the best specificity (%) and sensitivity (100%) in predicting complete recovery in patients with mTBI. IL-10 had the best specificity (50%) and sensitivity (96%) in identifying patients with favorable outcome in patients with TBIs of all severities. When individual proteins were combined with clinical parameters, a model including H-FABP, NF-L, and ISS yielded a specificity of 56% and a sensitivity of 96% in predicting complete recovery in patients with mTBI. In predicting favorable outcome, a model consisting IL-10, age, and TBI severity reached a specificity of 80% and a sensitivity of 96% in patients with TBIs of all severities. Conclusion: Combining novel TBI biomarkers H-FABP and IL-10 with GFAP, NF-L and S100β and clinical parameters improves outcome prediction models in TBI.

Original languageEnglish
Article number376
Number of pages9
JournalFrontiers in Neurology
Volume11
DOIs
Publication statusPublished - 2 Jun 2020
MoE publication typeA1 Journal article-refereed

Keywords

  • biomarker
  • heart fatty-acid binding protein
  • interleukin 10
  • outcome
  • panel
  • protein
  • traumatic brain injury

Fingerprint Dive into the research topics of 'Interleukin 10 and Heart Fatty Acid-Binding Protein as Early Outcome Predictors in Patients With Traumatic Brain Injury'. Together they form a unique fingerprint.

  • Cite this

    Lagerstedt, L., Azurmendi, L., Tenovuo, O., Katila, A. J., Takala, R. S. K., Blennow, K., Newcombe, V. F. J., Maanpää, H. R., Tallus, J., Hossain, I., Gils, M. V., Menon, D. K., Hutchinson, P. J., Zetterberg, H., Posti, J. P., & Sanchez, J. C. (2020). Interleukin 10 and Heart Fatty Acid-Binding Protein as Early Outcome Predictors in Patients With Traumatic Brain Injury. Frontiers in Neurology, 11, [376]. https://doi.org/10.3389/fneur.2020.00376