Interplay between cell adhesion and growth factor receptors

From the plasma membrane to the endosomes

Johanna Ivaska, Jyrki Heino (Corresponding Author)

Research output: Contribution to journalArticleScientificpeer-review

46 Citations (Scopus)

Abstract

The emergence of multicellular animals could only take place once evolution had produced molecular mechanisms for cell adhesion and communication. Today, all metazoans express integrin-type adhesion receptors and receptors for growth factors. Integrins recognize extracellular matrix proteins and respective receptors on other cells and, following ligand binding, can activate the same cellular signaling pathways that are regulated by growth factor receptors. Recent reports have indicated that the two receptor systems also collaborate in many other ways. Here, we review the present information concerning the role of integrins as assisting growth factor receptors and the interplay between the receptors in cell signaling and in the orchestration of receptor recycling.
Original languageEnglish
Pages (from-to)111-120
JournalCell and Tissue Research
Volume339
Issue number1
DOIs
Publication statusPublished - 2010
MoE publication typeA1 Journal article-refereed

Fingerprint

Growth Factor Receptors
Endosomes
Integrins
Cell Membrane
Extracellular Matrix Proteins
Cell Adhesion
Cell Communication
Ligands
cell aggregation factors

Keywords

  • Cell adhesion
  • Endocytosis
  • Growth factor
  • Integrin
  • Signaling

Cite this

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Interplay between cell adhesion and growth factor receptors : From the plasma membrane to the endosomes. / Ivaska, Johanna; Heino, Jyrki (Corresponding Author).

In: Cell and Tissue Research, Vol. 339, No. 1, 2010, p. 111-120.

Research output: Contribution to journalArticleScientificpeer-review

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T1 - Interplay between cell adhesion and growth factor receptors

T2 - From the plasma membrane to the endosomes

AU - Ivaska, Johanna

AU - Heino, Jyrki

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AB - The emergence of multicellular animals could only take place once evolution had produced molecular mechanisms for cell adhesion and communication. Today, all metazoans express integrin-type adhesion receptors and receptors for growth factors. Integrins recognize extracellular matrix proteins and respective receptors on other cells and, following ligand binding, can activate the same cellular signaling pathways that are regulated by growth factor receptors. Recent reports have indicated that the two receptor systems also collaborate in many other ways. Here, we review the present information concerning the role of integrins as assisting growth factor receptors and the interplay between the receptors in cell signaling and in the orchestration of receptor recycling.

KW - Cell adhesion

KW - Endocytosis

KW - Growth factor

KW - Integrin

KW - Signaling

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DO - 10.1007/s00441-009-0857-z

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JO - Cell and Tissue Research

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