Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 111-120 |
| Journal | Cell and Tissue Research |
| Volume | 339 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2010 |
| MoE publication type | A1 Journal article-refereed |
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Keywords
- Cell adhesion
- Endocytosis
- Growth factor
- Integrin
- Signaling
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Interplay between cell adhesion and growth factor receptors : From the plasma membrane to the endosomes. / Ivaska, Johanna; Heino, Jyrki (Corresponding Author).
In: Cell and Tissue Research, Vol. 339, No. 1, 2010, p. 111-120.Research output: Contribution to journal › Article › Scientific › peer-review
TY - JOUR
T1 - Interplay between cell adhesion and growth factor receptors
T2 - From the plasma membrane to the endosomes
AU - Ivaska, Johanna
AU - Heino, Jyrki
PY - 2010
Y1 - 2010
N2 - The emergence of multicellular animals could only take place once evolution had produced molecular mechanisms for cell adhesion and communication. Today, all metazoans express integrin-type adhesion receptors and receptors for growth factors. Integrins recognize extracellular matrix proteins and respective receptors on other cells and, following ligand binding, can activate the same cellular signaling pathways that are regulated by growth factor receptors. Recent reports have indicated that the two receptor systems also collaborate in many other ways. Here, we review the present information concerning the role of integrins as assisting growth factor receptors and the interplay between the receptors in cell signaling and in the orchestration of receptor recycling.
AB - The emergence of multicellular animals could only take place once evolution had produced molecular mechanisms for cell adhesion and communication. Today, all metazoans express integrin-type adhesion receptors and receptors for growth factors. Integrins recognize extracellular matrix proteins and respective receptors on other cells and, following ligand binding, can activate the same cellular signaling pathways that are regulated by growth factor receptors. Recent reports have indicated that the two receptor systems also collaborate in many other ways. Here, we review the present information concerning the role of integrins as assisting growth factor receptors and the interplay between the receptors in cell signaling and in the orchestration of receptor recycling.
KW - Cell adhesion
KW - Endocytosis
KW - Growth factor
KW - Integrin
KW - Signaling
U2 - 10.1007/s00441-009-0857-z
DO - 10.1007/s00441-009-0857-z
M3 - Article
VL - 339
SP - 111
EP - 120
JO - Cell and Tissue Research
JF - Cell and Tissue Research
SN - 0302-766X
IS - 1
ER -