Interplay between cell adhesion and growth factor receptors: From the plasma membrane to the endosomes

Johanna Ivaska, Jyrki Heino (Corresponding Author)

Research output: Contribution to journalArticleScientificpeer-review

50 Citations (Scopus)


The emergence of multicellular animals could only take place once evolution had produced molecular mechanisms for cell adhesion and communication. Today, all metazoans express integrin-type adhesion receptors and receptors for growth factors. Integrins recognize extracellular matrix proteins and respective receptors on other cells and, following ligand binding, can activate the same cellular signaling pathways that are regulated by growth factor receptors. Recent reports have indicated that the two receptor systems also collaborate in many other ways. Here, we review the present information concerning the role of integrins as assisting growth factor receptors and the interplay between the receptors in cell signaling and in the orchestration of receptor recycling.
Original languageEnglish
Pages (from-to)111-120
JournalCell and Tissue Research
Issue number1
Publication statusPublished - 2010
MoE publication typeA1 Journal article-refereed



  • Cell adhesion
  • Endocytosis
  • Growth factor
  • Integrin
  • Signaling

Cite this