Abstract
In the future fast, simple and reliable biosensors will
be needed to detect various analytes from different
biosamples. This is due to fact that the needs of
traditional health care are changing. In the future
homecare of patients and peoples' responsibility for
their own health will increase. Also, different wellness
applications need new parameters to be analysed, reducing
costs of traditional health care, which are increasing
rapidly. One fascinating and promising sensor type for
these applications is an integrated optical
interferometric immunosensor, which is manufactured using
organic materials. The use of organic materials opens up
enormous possibilities to develop different biochemical
functions. In label free biosensors the measurement is
based on detecting changes in refractive index, which
typically are in the range of 10-6-10-8 [1]. In this
research, theoretically generated interferograms are used
to compare various signal processing methods. The goal is
to develop an efficient method to analyse the
interferogram. Different time domain signal processing
methods are studied to determine the measuring resolution
and efficiency of these methods. A low cost CCD -element
is used in detecting the interferogram dynamics. It was
found that in most of the signal processing methods the
measuring resolution was mainly limited by pixel size.
With calculation of Pearson's correlation coefficient,
subpixel resolution was achieved which means that
nanometer range optical path differences can be measured.
This results in the refractive index resolution of the
order of 10-7.
Original language | English |
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Title of host publication | Optical Diagnostics and Sensing VI |
Editors | Gerard L. Coté, Alexander V. Priezzhev |
Publisher | International Society for Optics and Photonics SPIE |
Pages | 138-148 |
ISBN (Print) | 978-0-8194-6136-0 |
DOIs | |
Publication status | Published - 2006 |
MoE publication type | A4 Article in a conference publication |
Event | Optical Diagnostics and Sensing VI - San Jose, United States Duration: 24 Jan 2006 → 25 Jan 2006 |
Publication series
Series | Proceedings of SPIE |
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Volume | 6094 |
ISSN | 0277-786X |
Conference
Conference | Optical Diagnostics and Sensing VI |
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Country/Territory | United States |
City | San Jose |
Period | 24/01/06 → 25/01/06 |
Keywords
- interferometry
- fringe pattern analysis
- time domain methods
- biosensor