Isoenergetic diets differing in their n-3 fatty acid and polyphenol content reflect different plasma and HDL-fraction lipidomic profiles in subjects at high cardiovascular risk

I. Bondia-Pons, Päivi Pöhö, L. Bozzetto, C. Vetrani, L. Patti, Anna-Marja Aura, G. Annuzzi, Tuulia Hyötyläinen, A.A. Rivellese, Matej Oresic (Corresponding Author)

Research output: Contribution to journalArticleScientificpeer-review

19 Citations (Scopus)

Abstract

Scope: Dysregulation of lipid homeostasis is related to multiple major healthcare problems. The aim of this study was to investigate the effects of n-3 fatty acid (FA) and polyphenol rich diets on plasma and HDL fraction lipidomic profiles in subjects at high cardiovascular risk. Methods and results: Ultra performance LC coupled to quadrupole TOF/MS mass spectrometry global lipidomic profiling was applied to plasma and HDL fraction from an 8 wk randomized intervention with four isoenergetic diets, differing in their natural n-3 FA and polyphenols content, in 78 subjects with a high BMI, abdominal obesity, and at least one other feature of the metabolic syndrome. Dependency network analysis showed a different pattern of associations between lipidomics, dietary, and clinical variables after the dietary interventions. The most remarkable associations between variables were observed after the diet high in n-3 FA and polyphenols, as the inverse association between gallic acid intake and LDL cholesterol levels, which was indirectly associated with a HDL cluster exclusively comprised lysophospholipids. Conclusion: This is the first human randomized controlled trial showing direct and indirect associations with lipid molecular species and clinical variables of interest in the evaluation of the metabolic syndrome after diets naturally rich in polyphenols.
Original languageEnglish
Pages (from-to)1873-1882
Number of pages9
JournalMolecular Nutrition and Food Research
Volume58
Issue number9
DOIs
Publication statusPublished - 2014
MoE publication typeA1 Journal article-refereed

Fingerprint

Omega-3 Fatty Acids
Polyphenols
omega-3 fatty acids
polyphenols
Diet
metabolic syndrome
diet
Lysophospholipids
Lipids
Gallic Acid
Abdominal Obesity
lipids
gallic acid
low density lipoprotein cholesterol
LDL Cholesterol
health services
Mass Spectrometry
homeostasis
obesity
Homeostasis

Keywords

  • cardiovascular disease
  • lipidomics
  • n-3 fatty acids
  • plasmalogens
  • polyphenols

Cite this

Bondia-Pons, I. ; Pöhö, Päivi ; Bozzetto, L. ; Vetrani, C. ; Patti, L. ; Aura, Anna-Marja ; Annuzzi, G. ; Hyötyläinen, Tuulia ; Rivellese, A.A. ; Oresic, Matej. / Isoenergetic diets differing in their n-3 fatty acid and polyphenol content reflect different plasma and HDL-fraction lipidomic profiles in subjects at high cardiovascular risk. In: Molecular Nutrition and Food Research. 2014 ; Vol. 58, No. 9. pp. 1873-1882.
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abstract = "Scope: Dysregulation of lipid homeostasis is related to multiple major healthcare problems. The aim of this study was to investigate the effects of n-3 fatty acid (FA) and polyphenol rich diets on plasma and HDL fraction lipidomic profiles in subjects at high cardiovascular risk. Methods and results: Ultra performance LC coupled to quadrupole TOF/MS mass spectrometry global lipidomic profiling was applied to plasma and HDL fraction from an 8 wk randomized intervention with four isoenergetic diets, differing in their natural n-3 FA and polyphenols content, in 78 subjects with a high BMI, abdominal obesity, and at least one other feature of the metabolic syndrome. Dependency network analysis showed a different pattern of associations between lipidomics, dietary, and clinical variables after the dietary interventions. The most remarkable associations between variables were observed after the diet high in n-3 FA and polyphenols, as the inverse association between gallic acid intake and LDL cholesterol levels, which was indirectly associated with a HDL cluster exclusively comprised lysophospholipids. Conclusion: This is the first human randomized controlled trial showing direct and indirect associations with lipid molecular species and clinical variables of interest in the evaluation of the metabolic syndrome after diets naturally rich in polyphenols.",
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Isoenergetic diets differing in their n-3 fatty acid and polyphenol content reflect different plasma and HDL-fraction lipidomic profiles in subjects at high cardiovascular risk. / Bondia-Pons, I.; Pöhö, Päivi; Bozzetto, L.; Vetrani, C.; Patti, L.; Aura, Anna-Marja; Annuzzi, G.; Hyötyläinen, Tuulia; Rivellese, A.A.; Oresic, Matej (Corresponding Author).

In: Molecular Nutrition and Food Research, Vol. 58, No. 9, 2014, p. 1873-1882.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Isoenergetic diets differing in their n-3 fatty acid and polyphenol content reflect different plasma and HDL-fraction lipidomic profiles in subjects at high cardiovascular risk

AU - Bondia-Pons, I.

AU - Pöhö, Päivi

AU - Bozzetto, L.

AU - Vetrani, C.

AU - Patti, L.

AU - Aura, Anna-Marja

AU - Annuzzi, G.

AU - Hyötyläinen, Tuulia

AU - Rivellese, A.A.

AU - Oresic, Matej

PY - 2014

Y1 - 2014

N2 - Scope: Dysregulation of lipid homeostasis is related to multiple major healthcare problems. The aim of this study was to investigate the effects of n-3 fatty acid (FA) and polyphenol rich diets on plasma and HDL fraction lipidomic profiles in subjects at high cardiovascular risk. Methods and results: Ultra performance LC coupled to quadrupole TOF/MS mass spectrometry global lipidomic profiling was applied to plasma and HDL fraction from an 8 wk randomized intervention with four isoenergetic diets, differing in their natural n-3 FA and polyphenols content, in 78 subjects with a high BMI, abdominal obesity, and at least one other feature of the metabolic syndrome. Dependency network analysis showed a different pattern of associations between lipidomics, dietary, and clinical variables after the dietary interventions. The most remarkable associations between variables were observed after the diet high in n-3 FA and polyphenols, as the inverse association between gallic acid intake and LDL cholesterol levels, which was indirectly associated with a HDL cluster exclusively comprised lysophospholipids. Conclusion: This is the first human randomized controlled trial showing direct and indirect associations with lipid molecular species and clinical variables of interest in the evaluation of the metabolic syndrome after diets naturally rich in polyphenols.

AB - Scope: Dysregulation of lipid homeostasis is related to multiple major healthcare problems. The aim of this study was to investigate the effects of n-3 fatty acid (FA) and polyphenol rich diets on plasma and HDL fraction lipidomic profiles in subjects at high cardiovascular risk. Methods and results: Ultra performance LC coupled to quadrupole TOF/MS mass spectrometry global lipidomic profiling was applied to plasma and HDL fraction from an 8 wk randomized intervention with four isoenergetic diets, differing in their natural n-3 FA and polyphenols content, in 78 subjects with a high BMI, abdominal obesity, and at least one other feature of the metabolic syndrome. Dependency network analysis showed a different pattern of associations between lipidomics, dietary, and clinical variables after the dietary interventions. The most remarkable associations between variables were observed after the diet high in n-3 FA and polyphenols, as the inverse association between gallic acid intake and LDL cholesterol levels, which was indirectly associated with a HDL cluster exclusively comprised lysophospholipids. Conclusion: This is the first human randomized controlled trial showing direct and indirect associations with lipid molecular species and clinical variables of interest in the evaluation of the metabolic syndrome after diets naturally rich in polyphenols.

KW - cardiovascular disease

KW - lipidomics

KW - n-3 fatty acids

KW - plasmalogens

KW - polyphenols

U2 - 10.1002/mnfr.201400155

DO - 10.1002/mnfr.201400155

M3 - Article

VL - 58

SP - 1873

EP - 1882

JO - Molecular Nutrition and Food Research

JF - Molecular Nutrition and Food Research

SN - 1613-4125

IS - 9

ER -