Kinetics of the metal components of intratracheally instilled stainless steel welding fume suspensions in rats

Pirkko-Liisa Kalliomäki, Hanna-Kaisa Hyvärinen, A. Aitio, Eeva-Liisa Lakomaa, K. Kalliomäki

Research output: Contribution to journalArticleScientificpeer-review

14 Citations (Scopus)

Abstract

The kinetics of iron, chromium, nickel, and cobalt from manual metal arc and metal inert gas stainless steel welding fumes were studied. Neutron activated welding fumes, in aqueous suspensions, were instilled intratracheally into rats. The follow up continued for up to 106 days. From both fumes, approximately 10% of the injection bolus was immediately lost into the gastrointestinal tract, to be recovered in the faeces within three days. Thereafter, a pronounced difference was seen in the kinetics of the two types of fumes. After the first day, chromium, nickel, and iron were lost from the lungs with half times of about 53, 49, and 73 days after exposure to MMA/SS fumes, whereas practically no loss could be seen in the metal components of the metal inert gas welding fumes within two months. The disposition of chromium from MMA/SS fumes closely resembled that of intratracheally instilled water soluble chromates. On the other hand, the disappearance of trivalent chromium from MIS/SS fumes was considerably slower than that of the practically water insoluble chromates, or even of trivalent chromium salts. Thus the physical characteristics of the fume appreciably affect the kinetics of the clearance of chromium compounds from the lungs.

Original languageEnglish
Pages (from-to)112 - 119
Number of pages8
JournalBritish Journal of Industrial Medicine
Volume43
Issue number2
DOIs
Publication statusPublished - 1986
MoE publication typeNot Eligible

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Welding
Stainless Steel
Chromium
Suspensions
Metals
Chromates
Noble Gases
Nickel
Iron
Chromium Compounds
Lung
Water
Neutrons
Cobalt
Feces
Gastrointestinal Tract
Salts
Injections

Keywords

  • welding

Cite this

Kalliomäki, Pirkko-Liisa ; Hyvärinen, Hanna-Kaisa ; Aitio, A. ; Lakomaa, Eeva-Liisa ; Kalliomäki, K. / Kinetics of the metal components of intratracheally instilled stainless steel welding fume suspensions in rats. In: British Journal of Industrial Medicine. 1986 ; Vol. 43, No. 2. pp. 112 - 119.
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abstract = "The kinetics of iron, chromium, nickel, and cobalt from manual metal arc and metal inert gas stainless steel welding fumes were studied. Neutron activated welding fumes, in aqueous suspensions, were instilled intratracheally into rats. The follow up continued for up to 106 days. From both fumes, approximately 10{\%} of the injection bolus was immediately lost into the gastrointestinal tract, to be recovered in the faeces within three days. Thereafter, a pronounced difference was seen in the kinetics of the two types of fumes. After the first day, chromium, nickel, and iron were lost from the lungs with half times of about 53, 49, and 73 days after exposure to MMA/SS fumes, whereas practically no loss could be seen in the metal components of the metal inert gas welding fumes within two months. The disposition of chromium from MMA/SS fumes closely resembled that of intratracheally instilled water soluble chromates. On the other hand, the disappearance of trivalent chromium from MIS/SS fumes was considerably slower than that of the practically water insoluble chromates, or even of trivalent chromium salts. Thus the physical characteristics of the fume appreciably affect the kinetics of the clearance of chromium compounds from the lungs.",
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Kinetics of the metal components of intratracheally instilled stainless steel welding fume suspensions in rats. / Kalliomäki, Pirkko-Liisa; Hyvärinen, Hanna-Kaisa; Aitio, A.; Lakomaa, Eeva-Liisa; Kalliomäki, K.

In: British Journal of Industrial Medicine, Vol. 43, No. 2, 1986, p. 112 - 119.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Kinetics of the metal components of intratracheally instilled stainless steel welding fume suspensions in rats

AU - Kalliomäki, Pirkko-Liisa

AU - Hyvärinen, Hanna-Kaisa

AU - Aitio, A.

AU - Lakomaa, Eeva-Liisa

AU - Kalliomäki, K.

PY - 1986

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N2 - The kinetics of iron, chromium, nickel, and cobalt from manual metal arc and metal inert gas stainless steel welding fumes were studied. Neutron activated welding fumes, in aqueous suspensions, were instilled intratracheally into rats. The follow up continued for up to 106 days. From both fumes, approximately 10% of the injection bolus was immediately lost into the gastrointestinal tract, to be recovered in the faeces within three days. Thereafter, a pronounced difference was seen in the kinetics of the two types of fumes. After the first day, chromium, nickel, and iron were lost from the lungs with half times of about 53, 49, and 73 days after exposure to MMA/SS fumes, whereas practically no loss could be seen in the metal components of the metal inert gas welding fumes within two months. The disposition of chromium from MMA/SS fumes closely resembled that of intratracheally instilled water soluble chromates. On the other hand, the disappearance of trivalent chromium from MIS/SS fumes was considerably slower than that of the practically water insoluble chromates, or even of trivalent chromium salts. Thus the physical characteristics of the fume appreciably affect the kinetics of the clearance of chromium compounds from the lungs.

AB - The kinetics of iron, chromium, nickel, and cobalt from manual metal arc and metal inert gas stainless steel welding fumes were studied. Neutron activated welding fumes, in aqueous suspensions, were instilled intratracheally into rats. The follow up continued for up to 106 days. From both fumes, approximately 10% of the injection bolus was immediately lost into the gastrointestinal tract, to be recovered in the faeces within three days. Thereafter, a pronounced difference was seen in the kinetics of the two types of fumes. After the first day, chromium, nickel, and iron were lost from the lungs with half times of about 53, 49, and 73 days after exposure to MMA/SS fumes, whereas practically no loss could be seen in the metal components of the metal inert gas welding fumes within two months. The disposition of chromium from MMA/SS fumes closely resembled that of intratracheally instilled water soluble chromates. On the other hand, the disappearance of trivalent chromium from MIS/SS fumes was considerably slower than that of the practically water insoluble chromates, or even of trivalent chromium salts. Thus the physical characteristics of the fume appreciably affect the kinetics of the clearance of chromium compounds from the lungs.

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