Lactobacillus paracasei F19 is an emerging probiotic strain that shows
considerable promise for use in functional foods for intestinal health. In a
multicentre European research project, human feeding trials provided an
insight into the ability of this strain to survive gastric transit and
transiently colonize the human intestinal tract. Analysis of the faecal
microbiota in healthy human volunteers showed that a proportion of the
subjects carried a strain indistinguishable from L. paracasei F19 naturally
within their intestines. When consumed in different foods, L. paracasei F19
survived gastric transit in healthy infants, adults, and elderly subjects.
The bacterium transiently colonized both the colonic lumen and mucosa.
Molecular analysis of faecal and colonic biopsy samples from children fed the
probiotic showed that L. paracasei F19 did not perturb the population
dynamics of other major populations of bacteria in the intestinal microbiota.
This strain was well tolerated by young children, healthy adults, adults
with milk-hypersensitivity and elderly subjects infected with Helicobacter
- human health
- intestinal microbiota