Lactobacillus paracasei subsp. paracasei F19

Survival, ecology and safety in the human intestinal tract. A survey of feeding studies within the PROBDEMO project

Ross Crittenden, Maria Saarela, Jaana Mättö, A. C. Ouwehand, Seppo Salminen, L. Pelto, E. E. Vaughan, W. M. de Vos, Atte von Wright, R. Fonden, Tiina Mattila-Sandholm (Corresponding Author)

Research output: Contribution to journalArticleScientificpeer-review

35 Citations (Scopus)

Abstract

Lactobacillus paracasei F19 is an emerging probiotic strain that shows considerable promise for use in functional foods for intestinal health. In a multicentre European research project, human feeding trials provided an insight into the ability of this strain to survive gastric transit and transiently colonize the human intestinal tract. Analysis of the faecal microbiota in healthy human volunteers showed that a proportion of the subjects carried a strain indistinguishable from L. paracasei F19 naturally within their intestines. When consumed in different foods, L. paracasei F19 survived gastric transit in healthy infants, adults, and elderly subjects. The bacterium transiently colonized both the colonic lumen and mucosa. Molecular analysis of faecal and colonic biopsy samples from children fed the probiotic showed that L. paracasei F19 did not perturb the population dynamics of other major populations of bacteria in the intestinal microbiota. This strain was well tolerated by young children, healthy adults, adults with milk-hypersensitivity and elderly subjects infected with Helicobacter pylori.
Original languageEnglish
Pages (from-to)22-26
JournalMicrobial Ecology in Health and Disease
Volume14
Issue number1
DOIs
Publication statusPublished - 2002
MoE publication typeA1 Journal article-refereed

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Ecology
Safety
Survival
Probiotics
Stomach
Milk Hypersensitivity
Bacteria
Functional Food
Microbiota
Population Dynamics
Helicobacter pylori
Intestines
Healthy Volunteers
Mucous Membrane
Biopsy
Food
Surveys and Questionnaires
Lactobacillus paracasei
Health
Research

Keywords

  • lactobacillus
  • microbiota
  • paracasei
  • probiotic
  • survival
  • human health
  • intestinal microbiota

Cite this

Crittenden, Ross ; Saarela, Maria ; Mättö, Jaana ; Ouwehand, A. C. ; Salminen, Seppo ; Pelto, L. ; Vaughan, E. E. ; de Vos, W. M. ; von Wright, Atte ; Fonden, R. ; Mattila-Sandholm, Tiina. / Lactobacillus paracasei subsp. paracasei F19 : Survival, ecology and safety in the human intestinal tract. A survey of feeding studies within the PROBDEMO project. In: Microbial Ecology in Health and Disease. 2002 ; Vol. 14, No. 1. pp. 22-26.
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abstract = "Lactobacillus paracasei F19 is an emerging probiotic strain that shows considerable promise for use in functional foods for intestinal health. In a multicentre European research project, human feeding trials provided an insight into the ability of this strain to survive gastric transit and transiently colonize the human intestinal tract. Analysis of the faecal microbiota in healthy human volunteers showed that a proportion of the subjects carried a strain indistinguishable from L. paracasei F19 naturally within their intestines. When consumed in different foods, L. paracasei F19 survived gastric transit in healthy infants, adults, and elderly subjects. The bacterium transiently colonized both the colonic lumen and mucosa. Molecular analysis of faecal and colonic biopsy samples from children fed the probiotic showed that L. paracasei F19 did not perturb the population dynamics of other major populations of bacteria in the intestinal microbiota. This strain was well tolerated by young children, healthy adults, adults with milk-hypersensitivity and elderly subjects infected with Helicobacter pylori.",
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author = "Ross Crittenden and Maria Saarela and Jaana M{\"a}tt{\"o} and Ouwehand, {A. C.} and Seppo Salminen and L. Pelto and Vaughan, {E. E.} and {de Vos}, {W. M.} and {von Wright}, Atte and R. Fonden and Tiina Mattila-Sandholm",
year = "2002",
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language = "English",
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Crittenden, R, Saarela, M, Mättö, J, Ouwehand, AC, Salminen, S, Pelto, L, Vaughan, EE, de Vos, WM, von Wright, A, Fonden, R & Mattila-Sandholm, T 2002, 'Lactobacillus paracasei subsp. paracasei F19: Survival, ecology and safety in the human intestinal tract. A survey of feeding studies within the PROBDEMO project', Microbial Ecology in Health and Disease, vol. 14, no. 1, pp. 22-26. https://doi.org/10.1080/089106002760003314

Lactobacillus paracasei subsp. paracasei F19 : Survival, ecology and safety in the human intestinal tract. A survey of feeding studies within the PROBDEMO project. / Crittenden, Ross; Saarela, Maria; Mättö, Jaana; Ouwehand, A. C.; Salminen, Seppo; Pelto, L.; Vaughan, E. E.; de Vos, W. M.; von Wright, Atte; Fonden, R.; Mattila-Sandholm, Tiina (Corresponding Author).

In: Microbial Ecology in Health and Disease, Vol. 14, No. 1, 2002, p. 22-26.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Lactobacillus paracasei subsp. paracasei F19

T2 - Survival, ecology and safety in the human intestinal tract. A survey of feeding studies within the PROBDEMO project

AU - Crittenden, Ross

AU - Saarela, Maria

AU - Mättö, Jaana

AU - Ouwehand, A. C.

AU - Salminen, Seppo

AU - Pelto, L.

AU - Vaughan, E. E.

AU - de Vos, W. M.

AU - von Wright, Atte

AU - Fonden, R.

AU - Mattila-Sandholm, Tiina

PY - 2002

Y1 - 2002

N2 - Lactobacillus paracasei F19 is an emerging probiotic strain that shows considerable promise for use in functional foods for intestinal health. In a multicentre European research project, human feeding trials provided an insight into the ability of this strain to survive gastric transit and transiently colonize the human intestinal tract. Analysis of the faecal microbiota in healthy human volunteers showed that a proportion of the subjects carried a strain indistinguishable from L. paracasei F19 naturally within their intestines. When consumed in different foods, L. paracasei F19 survived gastric transit in healthy infants, adults, and elderly subjects. The bacterium transiently colonized both the colonic lumen and mucosa. Molecular analysis of faecal and colonic biopsy samples from children fed the probiotic showed that L. paracasei F19 did not perturb the population dynamics of other major populations of bacteria in the intestinal microbiota. This strain was well tolerated by young children, healthy adults, adults with milk-hypersensitivity and elderly subjects infected with Helicobacter pylori.

AB - Lactobacillus paracasei F19 is an emerging probiotic strain that shows considerable promise for use in functional foods for intestinal health. In a multicentre European research project, human feeding trials provided an insight into the ability of this strain to survive gastric transit and transiently colonize the human intestinal tract. Analysis of the faecal microbiota in healthy human volunteers showed that a proportion of the subjects carried a strain indistinguishable from L. paracasei F19 naturally within their intestines. When consumed in different foods, L. paracasei F19 survived gastric transit in healthy infants, adults, and elderly subjects. The bacterium transiently colonized both the colonic lumen and mucosa. Molecular analysis of faecal and colonic biopsy samples from children fed the probiotic showed that L. paracasei F19 did not perturb the population dynamics of other major populations of bacteria in the intestinal microbiota. This strain was well tolerated by young children, healthy adults, adults with milk-hypersensitivity and elderly subjects infected with Helicobacter pylori.

KW - lactobacillus

KW - microbiota

KW - paracasei

KW - probiotic

KW - survival

KW - human health

KW - intestinal microbiota

U2 - 10.1080/089106002760003314

DO - 10.1080/089106002760003314

M3 - Article

VL - 14

SP - 22

EP - 26

JO - Microbial Ecology in Health and Disease

JF - Microbial Ecology in Health and Disease

SN - 0891-060X

IS - 1

ER -