Large animal model for healthy tissue tolerance study in BNCT

Judit Benczik, Tiina Seppälä, J. Hopewell, M. Snellman, Iiro Auterinen, R. Joensuu, Usama Abo Ramadan, J. Tanttu, J. Vähätalo, Martti Kulvik, H. Joensuu, M. Tenhunen, Sauli Savolainen, M. Kallio, Markus Färkkilä

    Research output: Chapter in Book/Report/Conference proceedingConference article in proceedingsScientificpeer-review

    Abstract

    In radiotherapy where normal brain tissue is in the treatment field there is a risk of developing late radiation side effects. Consequently, evaluation of normal tissue tolerance is critical for the application of safe and effective treatment. The biological effectiveness of the calculated physical doses must be estimated before boron neutron capture therapy (BNCT) is applied clinically. Relative biological effectiveness (RBE) is a function of the energy of particles. As a consequence of the difference in neutron spec-trums in different BNCT facilities the RBE of each beam may be different. The aim of the healthy tissue tolerance study at the Finnish Research Reactor (FiR 1) was to obtain a complete dose effect curve for beam characterisation as part of the safety studies. The effects of high linear energy transfer (LET) radiation from the 10B(n,α)7Li reaction were compared with the effects of the beam-only irradiation. A large animal model (the dog brain) was used for the estimation of the probability of late radiation reactions as a function of dose. The endpoint of the study was visible magnetic resonance image (MRI) changes in the brain.
    Original languageEnglish
    Title of host publicationFrontiers in Neutron Capture Therapy
    Subtitle of host publicationProceedings of the 8th International Symposium on Neutron Capture Therapy for Cancer
    EditorsFrederic Hawthorne, Kenneth Shelly, Richard Wiersema
    PublisherSpringer
    Pages1233-1238
    Volume2
    ISBN (Electronic)978-1-4615-1285-1
    ISBN (Print)0-306-46442-X, 978-1-4613-5478-9
    DOIs
    Publication statusPublished - 2001
    MoE publication typeA4 Article in a conference publication
    Event8th International Symposium on Neutron Capture Therapy for Cancer - Los Angeles, United States
    Duration: 13 Aug 199818 Aug 1998

    Conference

    Conference8th International Symposium on Neutron Capture Therapy for Cancer
    CountryUnited States
    CityLos Angeles
    Period13/08/9818/08/98

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  • Cite this

    Benczik, J., Seppälä, T., Hopewell, J., Snellman, M., Auterinen, I., Joensuu, R., Ramadan, U. A., Tanttu, J., Vähätalo, J., Kulvik, M., Joensuu, H., Tenhunen, M., Savolainen, S., Kallio, M., & Färkkilä, M. (2001). Large animal model for healthy tissue tolerance study in BNCT. In F. Hawthorne, K. Shelly, & R. Wiersema (Eds.), Frontiers in Neutron Capture Therapy: Proceedings of the 8th International Symposium on Neutron Capture Therapy for Cancer (Vol. 2, pp. 1233-1238). Springer. https://doi.org/10.1007/978-1-4615-1285-1_187