Large animal model for healthy tissue tolerance study in BNCT

Judit Benczik; Tiina Seppälä; J. Hopewell; M. Snellman; Iiro Auterinen; R. Joensuu; Usama Abo Ramadan; J. Tanttu; J. Vähätalo; Martti Kulvik; H. Joensuu; M. Tenhunen; Sauli Savolainen; M. Kallio; Markus Färkkilä

doi:10.1007/978-1-4615-1285-1_187

Large animal model for healthy tissue tolerance study in BNCT

Judit Benczik, Tiina Seppälä, J. Hopewell, M. Snellman, Iiro Auterinen, R. Joensuu, Usama Abo Ramadan, J. Tanttu, J. Vähätalo, Martti Kulvik, H. Joensuu, M. Tenhunen, Sauli Savolainen, M. Kallio, Markus Färkkilä

Research output: Chapter in Book/Report/Conference proceeding › Conference article in proceedings › Scientific › peer-review

Abstract

In radiotherapy where normal brain tissue is in the treatment field there is a risk of developing late radiation side effects. Consequently, evaluation of normal tissue tolerance is critical for the application of safe and effective treatment. The biological effectiveness of the calculated physical doses must be estimated before boron neutron capture therapy (BNCT) is applied clinically. Relative biological effectiveness (RBE) is a function of the energy of particles. As a consequence of the difference in neutron spec-trums in different BNCT facilities the RBE of each beam may be different. The aim of the healthy tissue tolerance study at the Finnish Research Reactor (FiR 1) was to obtain a complete dose effect curve for beam characterisation as part of the safety studies. The effects of high linear energy transfer (LET) radiation from the ¹⁰B(n,α)⁷Li reaction were compared with the effects of the beam-only irradiation. A large animal model (the dog brain) was used for the estimation of the probability of late radiation reactions as a function of dose. The endpoint of the study was visible magnetic resonance image (MRI) changes in the brain.

Original language	English
Title of host publication	Frontiers in Neutron Capture Therapy
Subtitle of host publication	Proceedings of the 8th International Symposium on Neutron Capture Therapy for Cancer
Editors	Frederic Hawthorne, Kenneth Shelly, Richard Wiersema
Place of Publication	Boston
Publisher	Springer
Pages	1233-1238
Volume	2
ISBN (Electronic)	978-1-4615-1285-1
ISBN (Print)	978-1-4613-5478-9
DOIs	https://doi.org/10.1007/978-1-4615-1285-1_187
Publication status	Published - 2001
MoE publication type	A4 Article in a conference publication
Event	8th International Symposium on Neutron Capture Therapy for Cancer - Los Angeles, United States Duration: 13 Aug 1998 → 18 Aug 1998

Conference

Conference	8th International Symposium on Neutron Capture Therapy for Cancer
Country/Territory	United States
City	Los Angeles
Period	13/08/98 → 18/08/98

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10.1007/978-1-4615-1285-1_187

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Benczik, J., Seppälä, T., Hopewell, J., Snellman, M., Auterinen, I., Joensuu, R., Ramadan, U. A., Tanttu, J., Vähätalo, J., Kulvik, M., Joensuu, H., Tenhunen, M., Savolainen, S., Kallio, M., & Färkkilä, M. (2001). Large animal model for healthy tissue tolerance study in BNCT. In F. Hawthorne, K. Shelly, & R. Wiersema (Eds.), Frontiers in Neutron Capture Therapy: Proceedings of the 8th International Symposium on Neutron Capture Therapy for Cancer (Vol. 2, pp. 1233-1238). Springer. https://doi.org/10.1007/978-1-4615-1285-1_187

@inproceedings{c379d8895c4f43f697d70300953dd5d1,

title = "Large animal model for healthy tissue tolerance study in BNCT",

abstract = "In radiotherapy where normal brain tissue is in the treatment field there is a risk of developing late radiation side effects. Consequently, evaluation of normal tissue tolerance is critical for the application of safe and effective treatment. The biological effectiveness of the calculated physical doses must be estimated before boron neutron capture therapy (BNCT) is applied clinically. Relative biological effectiveness (RBE) is a function of the energy of particles. As a consequence of the difference in neutron spec-trums in different BNCT facilities the RBE of each beam may be different. The aim of the healthy tissue tolerance study at the Finnish Research Reactor (FiR 1) was to obtain a complete dose effect curve for beam characterisation as part of the safety studies. The effects of high linear energy transfer (LET) radiation from the 10B(n,α)7Li reaction were compared with the effects of the beam-only irradiation. A large animal model (the dog brain) was used for the estimation of the probability of late radiation reactions as a function of dose. The endpoint of the study was visible magnetic resonance image (MRI) changes in the brain.",

author = "Judit Benczik and Tiina Sepp{\"a}l{\"a} and J. Hopewell and M. Snellman and Iiro Auterinen and R. Joensuu and Ramadan, {Usama Abo} and J. Tanttu and J. V{\"a}h{\"a}talo and Martti Kulvik and H. Joensuu and M. Tenhunen and Sauli Savolainen and M. Kallio and Markus F{\"a}rkkil{\"a}",

year = "2001",

doi = "10.1007/978-1-4615-1285-1_187",

language = "English",

isbn = "978-1-4613-5478-9",

volume = "2",

pages = "1233--1238",

editor = "Frederic Hawthorne and Kenneth Shelly and Richard Wiersema",

booktitle = "Frontiers in Neutron Capture Therapy",

publisher = "Springer",

address = "Germany",

note = "8th International Symposium on Neutron Capture Therapy for Cancer ; Conference date: 13-08-1998 Through 18-08-1998",

}

Benczik, J, Seppälä, T, Hopewell, J, Snellman, M, Auterinen, I, Joensuu, R, Ramadan, UA, Tanttu, J, Vähätalo, J, Kulvik, M, Joensuu, H, Tenhunen, M, Savolainen, S, Kallio, M & Färkkilä, M 2001, Large animal model for healthy tissue tolerance study in BNCT. in F Hawthorne, K Shelly & R Wiersema (eds), Frontiers in Neutron Capture Therapy: Proceedings of the 8th International Symposium on Neutron Capture Therapy for Cancer. vol. 2, Springer, Boston, pp. 1233-1238, 8th International Symposium on Neutron Capture Therapy for Cancer, Los Angeles, California, United States, 13/08/98. https://doi.org/10.1007/978-1-4615-1285-1_187

Large animal model for healthy tissue tolerance study in BNCT. / Benczik, Judit; Seppälä, Tiina; Hopewell, J. et al.
Frontiers in Neutron Capture Therapy: Proceedings of the 8th International Symposium on Neutron Capture Therapy for Cancer. ed. / Frederic Hawthorne; Kenneth Shelly; Richard Wiersema. Vol. 2 Boston: Springer, 2001. p. 1233-1238.

Research output: Chapter in Book/Report/Conference proceeding › Conference article in proceedings › Scientific › peer-review

TY - GEN

T1 - Large animal model for healthy tissue tolerance study in BNCT

AU - Benczik, Judit

AU - Seppälä, Tiina

AU - Hopewell, J.

AU - Snellman, M.

AU - Auterinen, Iiro

AU - Joensuu, R.

AU - Ramadan, Usama Abo

AU - Tanttu, J.

AU - Vähätalo, J.

AU - Kulvik, Martti

AU - Joensuu, H.

AU - Tenhunen, M.

AU - Savolainen, Sauli

AU - Kallio, M.

AU - Färkkilä, Markus

PY - 2001

Y1 - 2001

N2 - In radiotherapy where normal brain tissue is in the treatment field there is a risk of developing late radiation side effects. Consequently, evaluation of normal tissue tolerance is critical for the application of safe and effective treatment. The biological effectiveness of the calculated physical doses must be estimated before boron neutron capture therapy (BNCT) is applied clinically. Relative biological effectiveness (RBE) is a function of the energy of particles. As a consequence of the difference in neutron spec-trums in different BNCT facilities the RBE of each beam may be different. The aim of the healthy tissue tolerance study at the Finnish Research Reactor (FiR 1) was to obtain a complete dose effect curve for beam characterisation as part of the safety studies. The effects of high linear energy transfer (LET) radiation from the 10B(n,α)7Li reaction were compared with the effects of the beam-only irradiation. A large animal model (the dog brain) was used for the estimation of the probability of late radiation reactions as a function of dose. The endpoint of the study was visible magnetic resonance image (MRI) changes in the brain.

AB - In radiotherapy where normal brain tissue is in the treatment field there is a risk of developing late radiation side effects. Consequently, evaluation of normal tissue tolerance is critical for the application of safe and effective treatment. The biological effectiveness of the calculated physical doses must be estimated before boron neutron capture therapy (BNCT) is applied clinically. Relative biological effectiveness (RBE) is a function of the energy of particles. As a consequence of the difference in neutron spec-trums in different BNCT facilities the RBE of each beam may be different. The aim of the healthy tissue tolerance study at the Finnish Research Reactor (FiR 1) was to obtain a complete dose effect curve for beam characterisation as part of the safety studies. The effects of high linear energy transfer (LET) radiation from the 10B(n,α)7Li reaction were compared with the effects of the beam-only irradiation. A large animal model (the dog brain) was used for the estimation of the probability of late radiation reactions as a function of dose. The endpoint of the study was visible magnetic resonance image (MRI) changes in the brain.

U2 - 10.1007/978-1-4615-1285-1_187

DO - 10.1007/978-1-4615-1285-1_187

M3 - Conference article in proceedings

SN - 978-1-4613-5478-9

VL - 2

SP - 1233

EP - 1238

BT - Frontiers in Neutron Capture Therapy

A2 - Hawthorne, Frederic

A2 - Shelly, Kenneth

A2 - Wiersema, Richard

PB - Springer

CY - Boston

T2 - 8th International Symposium on Neutron Capture Therapy for Cancer

Y2 - 13 August 1998 through 18 August 1998

ER -

Benczik J, Seppälä T, Hopewell J, Snellman M, Auterinen I, Joensuu R et al. Large animal model for healthy tissue tolerance study in BNCT. In Hawthorne F, Shelly K, Wiersema R, editors, Frontiers in Neutron Capture Therapy: Proceedings of the 8th International Symposium on Neutron Capture Therapy for Cancer. Vol. 2. Boston: Springer. 2001. p. 1233-1238 doi: 10.1007/978-1-4615-1285-1_187

Large animal model for healthy tissue tolerance study in BNCT

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