TY - JOUR
T1 - Large-scale bioprospecting of cyanobacteria, micro- and macroalgae from the Aegean Sea
AU - Montalvao, Sofia Isabel G. H. M.
AU - Demirel, Zeliha
AU - Devi, Prabha
AU - Lombardi, Valter
AU - Hongisto, Vesa
AU - Perälä, Merja
AU - Hattara, Johannes
AU - Imamoglu, Esra
AU - Tilvi, Supriya Shet
AU - Turan, Gamze
AU - Dalay, Meltem Conk
AU - Tammela, Päivi Sirpa Marjaana
PY - 2016
Y1 - 2016
N2 - Marine organisms constitute approximately one-half of the
total global biodiversity, being rich reservoirs of
structurally diverse biofunctional components. The
potential of cyanobacteria, micro- and macroalgae as
sources of antimicrobial, antitumoral, anti-inflammatory,
and anticoagulant compounds has been reported
extensively. Nonetheless, biological activities of marine
fauna and flora of the Aegean Sea have remained poorly
studied when in comparison to other areas of the
Mediterranean Sea. In this study, we screened the
antimicrobial, antifouling, anti-inflammatory and
anticancer potential of in total 98 specimens collected
from the Aegean Sea. Ethanol extract of diatom Amphora cf
capitellata showed the most promising antimicrobial
results against Candida albicans while the extract of
diatom Nitzschia communis showed effective results
against Gram-positive bacterium, S. aureus. Extracts from
the red alga Laurencia papillosa and from three
Cystoseira species exhibited selective antiproliferative
activity against cancer cell lines and an extract from
the brown alga Dilophus fasciola showed the highest
antiinflammatory activity as measured in primary
microglial and astrocyte cell cultures as well as by the
reduction of proinflammatory cytokines. In summary, our
study demonstrates that the Aegean Sea is a rich source
of species that possess interesting potential for
developing industrial applications.
AB - Marine organisms constitute approximately one-half of the
total global biodiversity, being rich reservoirs of
structurally diverse biofunctional components. The
potential of cyanobacteria, micro- and macroalgae as
sources of antimicrobial, antitumoral, anti-inflammatory,
and anticoagulant compounds has been reported
extensively. Nonetheless, biological activities of marine
fauna and flora of the Aegean Sea have remained poorly
studied when in comparison to other areas of the
Mediterranean Sea. In this study, we screened the
antimicrobial, antifouling, anti-inflammatory and
anticancer potential of in total 98 specimens collected
from the Aegean Sea. Ethanol extract of diatom Amphora cf
capitellata showed the most promising antimicrobial
results against Candida albicans while the extract of
diatom Nitzschia communis showed effective results
against Gram-positive bacterium, S. aureus. Extracts from
the red alga Laurencia papillosa and from three
Cystoseira species exhibited selective antiproliferative
activity against cancer cell lines and an extract from
the brown alga Dilophus fasciola showed the highest
antiinflammatory activity as measured in primary
microglial and astrocyte cell cultures as well as by the
reduction of proinflammatory cytokines. In summary, our
study demonstrates that the Aegean Sea is a rich source
of species that possess interesting potential for
developing industrial applications.
U2 - 10.1016/j.nbt.2016.02.002
DO - 10.1016/j.nbt.2016.02.002
M3 - Article
SN - 1871-6784
VL - 33
SP - 399
EP - 406
JO - New Biotechnology
JF - New Biotechnology
IS - 3
ER -
