Large-scale bioprospecting of cyanobacteria, micro- and macroalgae from the Aegean Sea

Sofia Isabel G. H. M. Montalvao, Zeliha Demirel, Prabha Devi, Valter Lombardi, Vesa Hongisto, Merja Perälä, Johannes Hattara, Esra Imamoglu, Supriya Shet Tilvi, Gamze Turan, Meltem Conk Dalay, Päivi Sirpa Marjaana Tammela (Corresponding Author)

Research output: Contribution to journalArticleScientificpeer-review

9 Citations (Scopus)

Abstract

Marine organisms constitute approximately one-half of the total global biodiversity, being rich reservoirs of structurally diverse biofunctional components. The potential of cyanobacteria, micro- and macroalgae as sources of antimicrobial, antitumoral, anti-inflammatory, and anticoagulant compounds has been reported extensively. Nonetheless, biological activities of marine fauna and flora of the Aegean Sea have remained poorly studied when in comparison to other areas of the Mediterranean Sea. In this study, we screened the antimicrobial, antifouling, anti-inflammatory and anticancer potential of in total 98 specimens collected from the Aegean Sea. Ethanol extract of diatom Amphora cf capitellata showed the most promising antimicrobial results against Candida albicans while the extract of diatom Nitzschia communis showed effective results against Gram-positive bacterium, S. aureus. Extracts from the red alga Laurencia papillosa and from three Cystoseira species exhibited selective antiproliferative activity against cancer cell lines and an extract from the brown alga Dilophus fasciola showed the highest antiinflammatory activity as measured in primary microglial and astrocyte cell cultures as well as by the reduction of proinflammatory cytokines. In summary, our study demonstrates that the Aegean Sea is a rich source of species that possess interesting potential for developing industrial applications.
Original languageEnglish
Pages (from-to)399-406
JournalNew Biotechnology
Volume33
Issue number3
DOIs
Publication statusPublished - 2016
MoE publication typeA1 Journal article-refereed

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Microalgae
Seaweed
Cyanobacteria
Algae
Oceans and Seas
Diatoms
Anti-Inflammatory Agents
Candida
Biodiversity
Laurencia
Bioactivity
Cell culture
Fasciola
Mediterranean Sea
Phaeophyta
Industrial applications
Rhodophyta
Aquatic Organisms
Bacteria
Ethanol

Cite this

Montalvao, S. I. G. H. M., Demirel, Z., Devi, P., Lombardi, V., Hongisto, V., Perälä, M., ... Tammela, P. S. M. (2016). Large-scale bioprospecting of cyanobacteria, micro- and macroalgae from the Aegean Sea. New Biotechnology, 33(3), 399-406. https://doi.org/10.1016/j.nbt.2016.02.002
Montalvao, Sofia Isabel G. H. M. ; Demirel, Zeliha ; Devi, Prabha ; Lombardi, Valter ; Hongisto, Vesa ; Perälä, Merja ; Hattara, Johannes ; Imamoglu, Esra ; Tilvi, Supriya Shet ; Turan, Gamze ; Dalay, Meltem Conk ; Tammela, Päivi Sirpa Marjaana. / Large-scale bioprospecting of cyanobacteria, micro- and macroalgae from the Aegean Sea. In: New Biotechnology. 2016 ; Vol. 33, No. 3. pp. 399-406.
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abstract = "Marine organisms constitute approximately one-half of the total global biodiversity, being rich reservoirs of structurally diverse biofunctional components. The potential of cyanobacteria, micro- and macroalgae as sources of antimicrobial, antitumoral, anti-inflammatory, and anticoagulant compounds has been reported extensively. Nonetheless, biological activities of marine fauna and flora of the Aegean Sea have remained poorly studied when in comparison to other areas of the Mediterranean Sea. In this study, we screened the antimicrobial, antifouling, anti-inflammatory and anticancer potential of in total 98 specimens collected from the Aegean Sea. Ethanol extract of diatom Amphora cf capitellata showed the most promising antimicrobial results against Candida albicans while the extract of diatom Nitzschia communis showed effective results against Gram-positive bacterium, S. aureus. Extracts from the red alga Laurencia papillosa and from three Cystoseira species exhibited selective antiproliferative activity against cancer cell lines and an extract from the brown alga Dilophus fasciola showed the highest antiinflammatory activity as measured in primary microglial and astrocyte cell cultures as well as by the reduction of proinflammatory cytokines. In summary, our study demonstrates that the Aegean Sea is a rich source of species that possess interesting potential for developing industrial applications.",
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Montalvao, SIGHM, Demirel, Z, Devi, P, Lombardi, V, Hongisto, V, Perälä, M, Hattara, J, Imamoglu, E, Tilvi, SS, Turan, G, Dalay, MC & Tammela, PSM 2016, 'Large-scale bioprospecting of cyanobacteria, micro- and macroalgae from the Aegean Sea', New Biotechnology, vol. 33, no. 3, pp. 399-406. https://doi.org/10.1016/j.nbt.2016.02.002

Large-scale bioprospecting of cyanobacteria, micro- and macroalgae from the Aegean Sea. / Montalvao, Sofia Isabel G. H. M.; Demirel, Zeliha; Devi, Prabha; Lombardi, Valter; Hongisto, Vesa; Perälä, Merja; Hattara, Johannes; Imamoglu, Esra; Tilvi, Supriya Shet; Turan, Gamze; Dalay, Meltem Conk; Tammela, Päivi Sirpa Marjaana (Corresponding Author).

In: New Biotechnology, Vol. 33, No. 3, 2016, p. 399-406.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Large-scale bioprospecting of cyanobacteria, micro- and macroalgae from the Aegean Sea

AU - Montalvao, Sofia Isabel G. H. M.

AU - Demirel, Zeliha

AU - Devi, Prabha

AU - Lombardi, Valter

AU - Hongisto, Vesa

AU - Perälä, Merja

AU - Hattara, Johannes

AU - Imamoglu, Esra

AU - Tilvi, Supriya Shet

AU - Turan, Gamze

AU - Dalay, Meltem Conk

AU - Tammela, Päivi Sirpa Marjaana

PY - 2016

Y1 - 2016

N2 - Marine organisms constitute approximately one-half of the total global biodiversity, being rich reservoirs of structurally diverse biofunctional components. The potential of cyanobacteria, micro- and macroalgae as sources of antimicrobial, antitumoral, anti-inflammatory, and anticoagulant compounds has been reported extensively. Nonetheless, biological activities of marine fauna and flora of the Aegean Sea have remained poorly studied when in comparison to other areas of the Mediterranean Sea. In this study, we screened the antimicrobial, antifouling, anti-inflammatory and anticancer potential of in total 98 specimens collected from the Aegean Sea. Ethanol extract of diatom Amphora cf capitellata showed the most promising antimicrobial results against Candida albicans while the extract of diatom Nitzschia communis showed effective results against Gram-positive bacterium, S. aureus. Extracts from the red alga Laurencia papillosa and from three Cystoseira species exhibited selective antiproliferative activity against cancer cell lines and an extract from the brown alga Dilophus fasciola showed the highest antiinflammatory activity as measured in primary microglial and astrocyte cell cultures as well as by the reduction of proinflammatory cytokines. In summary, our study demonstrates that the Aegean Sea is a rich source of species that possess interesting potential for developing industrial applications.

AB - Marine organisms constitute approximately one-half of the total global biodiversity, being rich reservoirs of structurally diverse biofunctional components. The potential of cyanobacteria, micro- and macroalgae as sources of antimicrobial, antitumoral, anti-inflammatory, and anticoagulant compounds has been reported extensively. Nonetheless, biological activities of marine fauna and flora of the Aegean Sea have remained poorly studied when in comparison to other areas of the Mediterranean Sea. In this study, we screened the antimicrobial, antifouling, anti-inflammatory and anticancer potential of in total 98 specimens collected from the Aegean Sea. Ethanol extract of diatom Amphora cf capitellata showed the most promising antimicrobial results against Candida albicans while the extract of diatom Nitzschia communis showed effective results against Gram-positive bacterium, S. aureus. Extracts from the red alga Laurencia papillosa and from three Cystoseira species exhibited selective antiproliferative activity against cancer cell lines and an extract from the brown alga Dilophus fasciola showed the highest antiinflammatory activity as measured in primary microglial and astrocyte cell cultures as well as by the reduction of proinflammatory cytokines. In summary, our study demonstrates that the Aegean Sea is a rich source of species that possess interesting potential for developing industrial applications.

U2 - 10.1016/j.nbt.2016.02.002

DO - 10.1016/j.nbt.2016.02.002

M3 - Article

VL - 33

SP - 399

EP - 406

JO - New Biotechnology

JF - New Biotechnology

SN - 1871-6784

IS - 3

ER -

Montalvao SIGHM, Demirel Z, Devi P, Lombardi V, Hongisto V, Perälä M et al. Large-scale bioprospecting of cyanobacteria, micro- and macroalgae from the Aegean Sea. New Biotechnology. 2016;33(3):399-406. https://doi.org/10.1016/j.nbt.2016.02.002