Layered polymer: Inorganic composite waveguides for biosensor applications

Jussi Hiltunen, M. Wang, Christina Liedert, Sanna Aikio, Noriyuki Masuda, S. Pearce, M. Charlton, Pentti Karioja

Research output: Chapter in Book/Report/Conference proceedingConference article in proceedingsScientificpeer-review

Abstract

In this work, we investigate the usability of layered polymer - inorganic composite waveguides for label-free sensing of surface bound bioreactions in an aqueous environment. The waveguide structure consists of a nanoimprint fabricated polymeric inverted rib waveguide with a sputtered Ta2O5 thin film on top. The interaction of the optical field with the surface is increased as a consequence of the mode profile localization near the surface, when high-index coating is deposited on a low-index waveguide. Young interferometer configuration with reference and sensors waveguide arms was utilized in sensor chips. Light from a laser source was end-fire coupled into the chips and interference pattern produced by the outcoupled light was investigated. External μ-fluidic pump was used to produce the analyte flow. Ambient refractive index change was characterized by applying DI-water with varying glucose concentration on waveguides. With the waveguide length of 1 cm a detection limit in the order of 10-7 - 10-6 refractive index unit (RIU) was achieved. Specific binding reactions on the surface were investigated with C - reactive protein (CRP) antibodies and antigens.
Original languageEnglish
Title of host publicationBiophotonics
Subtitle of host publicationPhotonic Solutions for Better Health Care III
PublisherInternational Society for Optics and Photonics SPIE
ISBN (Print)978-081949119-0
DOIs
Publication statusPublished - 2012
MoE publication typeNot Eligible
EventBiophotonics: Photonic Solutions for Better Health Care III - Brussels, Belgium
Duration: 16 Apr 201219 Apr 2012

Publication series

SeriesProceedings of SPIE
Volume8427

Conference

ConferenceBiophotonics
CountryBelgium
CityBrussels
Period16/04/1219/04/12

Fingerprint

bioinstrumentation
waveguides
composite materials
polymers
chips
refractivity
fluidics
sensors
antigens
antibodies
glucose
interferometers
pumps
proteins
interference
coatings
thin films
profiles
configurations
water

Keywords

  • Imprinting
  • integrated optics
  • nanoimprinting
  • waveguide

Cite this

Hiltunen, J., Wang, M., Liedert, C., Aikio, S., Masuda, N., Pearce, S., ... Karioja, P. (2012). Layered polymer: Inorganic composite waveguides for biosensor applications. In Biophotonics: Photonic Solutions for Better Health Care III [84270I] International Society for Optics and Photonics SPIE. Proceedings of SPIE, Vol.. 8427 https://doi.org/10.1117/12.922267
Hiltunen, Jussi ; Wang, M. ; Liedert, Christina ; Aikio, Sanna ; Masuda, Noriyuki ; Pearce, S. ; Charlton, M. ; Karioja, Pentti. / Layered polymer : Inorganic composite waveguides for biosensor applications. Biophotonics: Photonic Solutions for Better Health Care III. International Society for Optics and Photonics SPIE, 2012. (Proceedings of SPIE, Vol. 8427).
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abstract = "In this work, we investigate the usability of layered polymer - inorganic composite waveguides for label-free sensing of surface bound bioreactions in an aqueous environment. The waveguide structure consists of a nanoimprint fabricated polymeric inverted rib waveguide with a sputtered Ta2O5 thin film on top. The interaction of the optical field with the surface is increased as a consequence of the mode profile localization near the surface, when high-index coating is deposited on a low-index waveguide. Young interferometer configuration with reference and sensors waveguide arms was utilized in sensor chips. Light from a laser source was end-fire coupled into the chips and interference pattern produced by the outcoupled light was investigated. External μ-fluidic pump was used to produce the analyte flow. Ambient refractive index change was characterized by applying DI-water with varying glucose concentration on waveguides. With the waveguide length of 1 cm a detection limit in the order of 10-7 - 10-6 refractive index unit (RIU) was achieved. Specific binding reactions on the surface were investigated with C - reactive protein (CRP) antibodies and antigens.",
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Hiltunen, J, Wang, M, Liedert, C, Aikio, S, Masuda, N, Pearce, S, Charlton, M & Karioja, P 2012, Layered polymer: Inorganic composite waveguides for biosensor applications. in Biophotonics: Photonic Solutions for Better Health Care III., 84270I, International Society for Optics and Photonics SPIE, Proceedings of SPIE, vol. 8427, Biophotonics, Brussels, Belgium, 16/04/12. https://doi.org/10.1117/12.922267

Layered polymer : Inorganic composite waveguides for biosensor applications. / Hiltunen, Jussi; Wang, M.; Liedert, Christina; Aikio, Sanna; Masuda, Noriyuki; Pearce, S.; Charlton, M.; Karioja, Pentti.

Biophotonics: Photonic Solutions for Better Health Care III. International Society for Optics and Photonics SPIE, 2012. 84270I (Proceedings of SPIE, Vol. 8427).

Research output: Chapter in Book/Report/Conference proceedingConference article in proceedingsScientificpeer-review

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Hiltunen J, Wang M, Liedert C, Aikio S, Masuda N, Pearce S et al. Layered polymer: Inorganic composite waveguides for biosensor applications. In Biophotonics: Photonic Solutions for Better Health Care III. International Society for Optics and Photonics SPIE. 2012. 84270I. (Proceedings of SPIE, Vol. 8427). https://doi.org/10.1117/12.922267