In contrast to the traditional applications of lipid analysis, lipidomics aims to study the complete composition of lipids and their biological roles for a specific organism. Such studies are becoming possible with advances in analytical technologies and emergence of systems biology approaches. Liquid chromatography/mass spectrometry enables determination of molecular species from several major lipid classes within a single sample run and we are using it to create complete (global) profiles of the lipids. Methods for data processing and multivariate analysis needed for the utilization of such data are presented. In particular, we introduce the use of principal components analysis and correlation networks for comparative studies of observed phenotypes, with the aim of finding phenotype-specific lipidomic patterns.
|Pages (from-to)||59 - 63|
|Number of pages||5|
|Publication status||Published - 2005|
|MoE publication type||A1 Journal article-refereed|