Lipidomics as a tool for characterizing biological systems

Matej Orešič, Mikko Katajamaa, Tuulikki Seppänen-Laakso

    Research output: Contribution to journalArticleScientificpeer-review


    In contrast to the traditional applications of lipid analysis, lipidomics aims to study the complete composition of lipids and their biological roles for a specific organism. Such studies are becoming possible with advances in analytical technologies and emergence of systems biology approaches. Liquid chromatography/mass spectrometry enables determination of molecular species from several major lipid classes within a single sample run and we are using it to create complete (global) profiles of the lipids. Methods for data processing and multivariate analysis needed for the utilization of such data are presented. In particular, we introduce the use of principal components analysis and correlation networks for comparative studies of observed phenotypes, with the aim of finding phenotype-specific lipidomic patterns.
    Original languageEnglish
    Pages (from-to)59 - 63
    Number of pages5
    JournalLipid Technology
    Issue number3
    Publication statusPublished - 2005
    MoE publication typeA1 Journal article-refereed


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