Lipidomics as a tool for characterizing biological systems

Matej Orešič, Mikko Katajamaa, Tuulikki Seppänen-Laakso

Research output: Contribution to journalArticleScientificpeer-review

Abstract

In contrast to the traditional applications of lipid analysis, lipidomics aims to study the complete composition of lipids and their biological roles for a specific organism. Such studies are becoming possible with advances in analytical technologies and emergence of systems biology approaches. Liquid chromatography/mass spectrometry enables determination of molecular species from several major lipid classes within a single sample run and we are using it to create complete (global) profiles of the lipids. Methods for data processing and multivariate analysis needed for the utilization of such data are presented. In particular, we introduce the use of principal components analysis and correlation networks for comparative studies of observed phenotypes, with the aim of finding phenotype-specific lipidomic patterns.
Original languageEnglish
Pages (from-to)59 - 63
Number of pages5
JournalLipid Technology
Volume17
Issue number3
Publication statusPublished - 2005
MoE publication typeA1 Journal article-refereed

Fingerprint

Biological systems
Lipids
lipids
phenotype
lipid composition
Phenotype
liquid chromatography
multivariate analysis
Systems Biology
Liquid chromatography
principal component analysis
Principal Component Analysis
Liquid Chromatography
mass spectrometry
Principal component analysis
Mass spectrometry
Biological Sciences
Mass Spectrometry
Multivariate Analysis
organisms

Cite this

Orešič, Matej ; Katajamaa, Mikko ; Seppänen-Laakso, Tuulikki. / Lipidomics as a tool for characterizing biological systems. In: Lipid Technology. 2005 ; Vol. 17, No. 3. pp. 59 - 63.
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Orešič, M, Katajamaa, M & Seppänen-Laakso, T 2005, 'Lipidomics as a tool for characterizing biological systems', Lipid Technology, vol. 17, no. 3, pp. 59 - 63.

Lipidomics as a tool for characterizing biological systems. / Orešič, Matej; Katajamaa, Mikko; Seppänen-Laakso, Tuulikki.

In: Lipid Technology, Vol. 17, No. 3, 2005, p. 59 - 63.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Lipidomics as a tool for characterizing biological systems

AU - Orešič, Matej

AU - Katajamaa, Mikko

AU - Seppänen-Laakso, Tuulikki

PY - 2005

Y1 - 2005

N2 - In contrast to the traditional applications of lipid analysis, lipidomics aims to study the complete composition of lipids and their biological roles for a specific organism. Such studies are becoming possible with advances in analytical technologies and emergence of systems biology approaches. Liquid chromatography/mass spectrometry enables determination of molecular species from several major lipid classes within a single sample run and we are using it to create complete (global) profiles of the lipids. Methods for data processing and multivariate analysis needed for the utilization of such data are presented. In particular, we introduce the use of principal components analysis and correlation networks for comparative studies of observed phenotypes, with the aim of finding phenotype-specific lipidomic patterns.

AB - In contrast to the traditional applications of lipid analysis, lipidomics aims to study the complete composition of lipids and their biological roles for a specific organism. Such studies are becoming possible with advances in analytical technologies and emergence of systems biology approaches. Liquid chromatography/mass spectrometry enables determination of molecular species from several major lipid classes within a single sample run and we are using it to create complete (global) profiles of the lipids. Methods for data processing and multivariate analysis needed for the utilization of such data are presented. In particular, we introduce the use of principal components analysis and correlation networks for comparative studies of observed phenotypes, with the aim of finding phenotype-specific lipidomic patterns.

M3 - Article

VL - 17

SP - 59

EP - 63

JO - Lipid Technology

JF - Lipid Technology

SN - 0956-666X

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