Low-temperature aerosol flow reactor method for preparation of surface stabilized pharmaceutical nanocarriers

Tiina Torvela (Corresponding Author), Anna Lähde, Juha Mönkäre, Joakim Riikonen, Kari E.J. Lehtinen, Kristiina Järvinen, Vesa-Pekka Lehto, Jorma Jokiniemi, Jorma Joutsensaari

Research output: Contribution to journalArticleScientificpeer-review

4 Citations (Scopus)

Abstract

Nanoparticles can be used to improve the delivery of many drugs, especially peptides and proteins. Although several methods are available for polymeric nanoparticle preparation, there are few single-stage processes that produce dry, solid nanoparticles that can be easily re-dispersed in pharmaceutical vehicles. The aerosol flow reactor method is a single-stage process that has been used for the preparation of multicomponent, coated nanoparticles under uniform temperature and gas flow field. However, it is traditionally used with high synthesis temperatures. In the present study, the aerosol flow reactor method was further optimized for processing and surface stabilization of pharmaceutical nanoparticles containing temperature sensitive biomolecules. In the developed method, drug-loaded carrier nanoparticles consisting of a biodegradable polymer (Eudragit L100) and a drug (phenylephrine hydrochloride) were first produced by aerosol droplet drying and subsequently coated in the gas phase. The carrier particles were coated with l-leucine in order to inhibit agglomeration of the nanoparticles in solutions before administration. In the coating process, a side stream of l-leucine vapor was directed into the main aerosol flow containing the drug-loaded carriers. The mixing with the main flow at ambient temperature induced a supersaturation of l-leucine vapor and condensation on the carrier particles. The results demonstrate that solid, hydrodynamically stable drug-loaded polymeric nanoparticles can be produced with a thin l-leucine coating. The low process temperature enables the surface engineering of particles loaded with temperature sensitive drugs or bioactive materials to be utilized for drug delivery purposes.
Original languageEnglish
Pages (from-to)645-656
JournalJournal of Aerosol Science
Volume42
Issue number10
DOIs
Publication statusPublished - 2011
MoE publication typeA1 Journal article-refereed

Fingerprint

Aerosols
Drug products
drug
aerosol
Nanoparticles
Leucine
Pharmaceutical Preparations
Temperature
Drug Carriers
temperature
Pharmaceutical Vehicles
coating
Vapors
Coatings
Biodegradable polymers
method
reactor
Supersaturation
Biomolecules
Phenylephrine

Keywords

  • Drug delivery
  • gas phase synthesis
  • polymeric nanoparticles
  • surface coating

Cite this

Torvela, T., Lähde, A., Mönkäre, J., Riikonen, J., Lehtinen, K. E. J., Järvinen, K., ... Joutsensaari, J. (2011). Low-temperature aerosol flow reactor method for preparation of surface stabilized pharmaceutical nanocarriers. Journal of Aerosol Science, 42(10), 645-656. https://doi.org/10.1016/j.jaerosci.2011.06.006
Torvela, Tiina ; Lähde, Anna ; Mönkäre, Juha ; Riikonen, Joakim ; Lehtinen, Kari E.J. ; Järvinen, Kristiina ; Lehto, Vesa-Pekka ; Jokiniemi, Jorma ; Joutsensaari, Jorma. / Low-temperature aerosol flow reactor method for preparation of surface stabilized pharmaceutical nanocarriers. In: Journal of Aerosol Science. 2011 ; Vol. 42, No. 10. pp. 645-656.
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Torvela, T, Lähde, A, Mönkäre, J, Riikonen, J, Lehtinen, KEJ, Järvinen, K, Lehto, V-P, Jokiniemi, J & Joutsensaari, J 2011, 'Low-temperature aerosol flow reactor method for preparation of surface stabilized pharmaceutical nanocarriers', Journal of Aerosol Science, vol. 42, no. 10, pp. 645-656. https://doi.org/10.1016/j.jaerosci.2011.06.006

Low-temperature aerosol flow reactor method for preparation of surface stabilized pharmaceutical nanocarriers. / Torvela, Tiina (Corresponding Author); Lähde, Anna; Mönkäre, Juha; Riikonen, Joakim; Lehtinen, Kari E.J.; Järvinen, Kristiina; Lehto, Vesa-Pekka; Jokiniemi, Jorma; Joutsensaari, Jorma.

In: Journal of Aerosol Science, Vol. 42, No. 10, 2011, p. 645-656.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Low-temperature aerosol flow reactor method for preparation of surface stabilized pharmaceutical nanocarriers

AU - Torvela, Tiina

AU - Lähde, Anna

AU - Mönkäre, Juha

AU - Riikonen, Joakim

AU - Lehtinen, Kari E.J.

AU - Järvinen, Kristiina

AU - Lehto, Vesa-Pekka

AU - Jokiniemi, Jorma

AU - Joutsensaari, Jorma

PY - 2011

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N2 - Nanoparticles can be used to improve the delivery of many drugs, especially peptides and proteins. Although several methods are available for polymeric nanoparticle preparation, there are few single-stage processes that produce dry, solid nanoparticles that can be easily re-dispersed in pharmaceutical vehicles. The aerosol flow reactor method is a single-stage process that has been used for the preparation of multicomponent, coated nanoparticles under uniform temperature and gas flow field. However, it is traditionally used with high synthesis temperatures. In the present study, the aerosol flow reactor method was further optimized for processing and surface stabilization of pharmaceutical nanoparticles containing temperature sensitive biomolecules. In the developed method, drug-loaded carrier nanoparticles consisting of a biodegradable polymer (Eudragit L100) and a drug (phenylephrine hydrochloride) were first produced by aerosol droplet drying and subsequently coated in the gas phase. The carrier particles were coated with l-leucine in order to inhibit agglomeration of the nanoparticles in solutions before administration. In the coating process, a side stream of l-leucine vapor was directed into the main aerosol flow containing the drug-loaded carriers. The mixing with the main flow at ambient temperature induced a supersaturation of l-leucine vapor and condensation on the carrier particles. The results demonstrate that solid, hydrodynamically stable drug-loaded polymeric nanoparticles can be produced with a thin l-leucine coating. The low process temperature enables the surface engineering of particles loaded with temperature sensitive drugs or bioactive materials to be utilized for drug delivery purposes.

AB - Nanoparticles can be used to improve the delivery of many drugs, especially peptides and proteins. Although several methods are available for polymeric nanoparticle preparation, there are few single-stage processes that produce dry, solid nanoparticles that can be easily re-dispersed in pharmaceutical vehicles. The aerosol flow reactor method is a single-stage process that has been used for the preparation of multicomponent, coated nanoparticles under uniform temperature and gas flow field. However, it is traditionally used with high synthesis temperatures. In the present study, the aerosol flow reactor method was further optimized for processing and surface stabilization of pharmaceutical nanoparticles containing temperature sensitive biomolecules. In the developed method, drug-loaded carrier nanoparticles consisting of a biodegradable polymer (Eudragit L100) and a drug (phenylephrine hydrochloride) were first produced by aerosol droplet drying and subsequently coated in the gas phase. The carrier particles were coated with l-leucine in order to inhibit agglomeration of the nanoparticles in solutions before administration. In the coating process, a side stream of l-leucine vapor was directed into the main aerosol flow containing the drug-loaded carriers. The mixing with the main flow at ambient temperature induced a supersaturation of l-leucine vapor and condensation on the carrier particles. The results demonstrate that solid, hydrodynamically stable drug-loaded polymeric nanoparticles can be produced with a thin l-leucine coating. The low process temperature enables the surface engineering of particles loaded with temperature sensitive drugs or bioactive materials to be utilized for drug delivery purposes.

KW - Drug delivery

KW - gas phase synthesis

KW - polymeric nanoparticles

KW - surface coating

U2 - 10.1016/j.jaerosci.2011.06.006

DO - 10.1016/j.jaerosci.2011.06.006

M3 - Article

VL - 42

SP - 645

EP - 656

JO - Journal of Aerosol Science

JF - Journal of Aerosol Science

SN - 0021-8502

IS - 10

ER -