MAGIC polymer gel for dosimetric verification in boron neutron capture therapy

Jouni Uusi-Simola, Sami Heikkinen, Petri Kotiluoto, Tom Serén, Tiina Seppaälä, Iiro Auterinen, Sauli Savolainen

Research output: Contribution to journalArticleScientificpeer-review

16 Citations (Scopus)

Abstract

Radiation-sensitive polymer gels are among the most promising three-dimensional dose verification tools developed to date. We tested the normoxic polymer gel dosimeter known by the acronym MAGIC (methacrylic and ascorbic acid in gelatin initiated by copper) to evaluate its use in boron neutron capture therapy (BNCT) dosimetry. We irradiated a large cylindrical gel phantom (diameter: 10 cm; length: 20 cm) in the epithermal neutron beam of the Finnish BNCT facility at the FiR 1 nuclear reactor. Neutron irradiation was simulated with a Monte Carlo radiation transport code MCNP. To compare dose-response, gel samples from the same production batch were also irradiated with 6 MV photons from a medical linear accelerator. Irradiated gel phantoms then underwent magnetic resonance imaging to determine their R2 relaxation rate maps. The measured and normalized dose distribution in the epithermal neutron beam was compared with the dose distribution calculated by computer simulation. The results support the feasibility of using MAGIC gel in BNCT dosimetry.

Original languageEnglish
Pages (from-to)114-123
Number of pages10
JournalJournal of Applied Clinical Medical Physics
Volume8
Issue number2
DOIs
Publication statusPublished - 1 Jan 2007
MoE publication typeA1 Journal article-refereed

Fingerprint

Boron Neutron Capture Therapy
ascorbic acid
Ascorbic acid
gelatins
Gelatin
Ascorbic Acid
Boron
Copper
therapy
Polymers
Neutrons
boron
Gels
gels
neutrons
copper
polymers
Dosimetry
dosimeters
Neutron beams

Keywords

  • BNCT
  • Gel dosimeter
  • MCNP
  • Neutron dosimetry

Cite this

Uusi-Simola, Jouni ; Heikkinen, Sami ; Kotiluoto, Petri ; Serén, Tom ; Seppaälä, Tiina ; Auterinen, Iiro ; Savolainen, Sauli. / MAGIC polymer gel for dosimetric verification in boron neutron capture therapy. In: Journal of Applied Clinical Medical Physics. 2007 ; Vol. 8, No. 2. pp. 114-123.
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MAGIC polymer gel for dosimetric verification in boron neutron capture therapy. / Uusi-Simola, Jouni; Heikkinen, Sami; Kotiluoto, Petri; Serén, Tom; Seppaälä, Tiina; Auterinen, Iiro; Savolainen, Sauli.

In: Journal of Applied Clinical Medical Physics, Vol. 8, No. 2, 01.01.2007, p. 114-123.

Research output: Contribution to journalArticleScientificpeer-review

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