MAGIC polymer gel for dosimetric verification in boron neutron capture therapy

Jouni Uusi-Simola; Sami Heikkinen; Petri Kotiluoto; Tom Serén; Tiina Seppaälä; Iiro Auterinen; Sauli Savolainen

doi:10.1120/jacmp.v8i2.2409

MAGIC polymer gel for dosimetric verification in boron neutron capture therapy

Jouni Uusi-Simola^*, Sami Heikkinen, Petri Kotiluoto, Tom Serén, Tiina Seppaälä, Iiro Auterinen, Sauli Savolainen

^*Corresponding author for this work

University of Helsinki

Research output: Contribution to journal › Article › Scientific › peer-review

18 Citations (Scopus)

Abstract

Radiation-sensitive polymer gels are among the most promising three-dimensional dose verification tools developed to date. We tested the normoxic polymer gel dosimeter known by the acronym MAGIC (methacrylic and ascorbic acid in gelatin initiated by copper) to evaluate its use in boron neutron capture therapy (BNCT) dosimetry. We irradiated a large cylindrical gel phantom (diameter: 10 cm; length: 20 cm) in the epithermal neutron beam of the Finnish BNCT facility at the FiR 1 nuclear reactor. Neutron irradiation was simulated with a Monte Carlo radiation transport code MCNP. To compare dose-response, gel samples from the same production batch were also irradiated with 6 MV photons from a medical linear accelerator. Irradiated gel phantoms then underwent magnetic resonance imaging to determine their R2 relaxation rate maps. The measured and normalized dose distribution in the epithermal neutron beam was compared with the dose distribution calculated by computer simulation. The results support the feasibility of using MAGIC gel in BNCT dosimetry.

Original language	English
Pages (from-to)	114-123
Number of pages	10
Journal	Journal of Applied Clinical Medical Physics
Volume	8
Issue number	2
DOIs	https://doi.org/10.1120/jacmp.v8i2.2409
Publication status	Published - 1 Jan 2007
MoE publication type	A1 Journal article-refereed

Keywords

BNCT
Gel dosimeter
MCNP
Neutron dosimetry

Access to Document

10.1120/jacmp.v8i2.2409Licence: CC BY

Cite this

@article{986997c0007241d7ba96feb3e6394e1d,

title = "MAGIC polymer gel for dosimetric verification in boron neutron capture therapy",

abstract = "Radiation-sensitive polymer gels are among the most promising three-dimensional dose verification tools developed to date. We tested the normoxic polymer gel dosimeter known by the acronym MAGIC (methacrylic and ascorbic acid in gelatin initiated by copper) to evaluate its use in boron neutron capture therapy (BNCT) dosimetry. We irradiated a large cylindrical gel phantom (diameter: 10 cm; length: 20 cm) in the epithermal neutron beam of the Finnish BNCT facility at the FiR 1 nuclear reactor. Neutron irradiation was simulated with a Monte Carlo radiation transport code MCNP. To compare dose-response, gel samples from the same production batch were also irradiated with 6 MV photons from a medical linear accelerator. Irradiated gel phantoms then underwent magnetic resonance imaging to determine their R2 relaxation rate maps. The measured and normalized dose distribution in the epithermal neutron beam was compared with the dose distribution calculated by computer simulation. The results support the feasibility of using MAGIC gel in BNCT dosimetry.",

keywords = "BNCT, Gel dosimeter, MCNP, Neutron dosimetry",

author = "Jouni Uusi-Simola and Sami Heikkinen and Petri Kotiluoto and Tom Ser{\'e}n and Tiina Seppa{\"a}l{\"a} and Iiro Auterinen and Sauli Savolainen",

year = "2007",

month = jan,

day = "1",

doi = "10.1120/jacmp.v8i2.2409",

language = "English",

volume = "8",

pages = "114--123",

journal = "Journal of Applied Clinical Medical Physics",

issn = "1526-9914",

publisher = "American Institute of Physics",

number = "2",

}

TY - JOUR

T1 - MAGIC polymer gel for dosimetric verification in boron neutron capture therapy

AU - Uusi-Simola, Jouni

AU - Heikkinen, Sami

AU - Kotiluoto, Petri

AU - Serén, Tom

AU - Seppaälä, Tiina

AU - Auterinen, Iiro

AU - Savolainen, Sauli

PY - 2007/1/1

Y1 - 2007/1/1

N2 - Radiation-sensitive polymer gels are among the most promising three-dimensional dose verification tools developed to date. We tested the normoxic polymer gel dosimeter known by the acronym MAGIC (methacrylic and ascorbic acid in gelatin initiated by copper) to evaluate its use in boron neutron capture therapy (BNCT) dosimetry. We irradiated a large cylindrical gel phantom (diameter: 10 cm; length: 20 cm) in the epithermal neutron beam of the Finnish BNCT facility at the FiR 1 nuclear reactor. Neutron irradiation was simulated with a Monte Carlo radiation transport code MCNP. To compare dose-response, gel samples from the same production batch were also irradiated with 6 MV photons from a medical linear accelerator. Irradiated gel phantoms then underwent magnetic resonance imaging to determine their R2 relaxation rate maps. The measured and normalized dose distribution in the epithermal neutron beam was compared with the dose distribution calculated by computer simulation. The results support the feasibility of using MAGIC gel in BNCT dosimetry.

AB - Radiation-sensitive polymer gels are among the most promising three-dimensional dose verification tools developed to date. We tested the normoxic polymer gel dosimeter known by the acronym MAGIC (methacrylic and ascorbic acid in gelatin initiated by copper) to evaluate its use in boron neutron capture therapy (BNCT) dosimetry. We irradiated a large cylindrical gel phantom (diameter: 10 cm; length: 20 cm) in the epithermal neutron beam of the Finnish BNCT facility at the FiR 1 nuclear reactor. Neutron irradiation was simulated with a Monte Carlo radiation transport code MCNP. To compare dose-response, gel samples from the same production batch were also irradiated with 6 MV photons from a medical linear accelerator. Irradiated gel phantoms then underwent magnetic resonance imaging to determine their R2 relaxation rate maps. The measured and normalized dose distribution in the epithermal neutron beam was compared with the dose distribution calculated by computer simulation. The results support the feasibility of using MAGIC gel in BNCT dosimetry.

KW - BNCT

KW - Gel dosimeter

KW - MCNP

KW - Neutron dosimetry

UR - http://www.scopus.com/inward/record.url?scp=34249938809&partnerID=8YFLogxK

U2 - 10.1120/jacmp.v8i2.2409

DO - 10.1120/jacmp.v8i2.2409

M3 - Article

C2 - 17592463

AN - SCOPUS:34249938809

SN - 1526-9914

VL - 8

SP - 114

EP - 123

JO - Journal of Applied Clinical Medical Physics

JF - Journal of Applied Clinical Medical Physics

IS - 2

ER -

MAGIC polymer gel for dosimetric verification in boron neutron capture therapy

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this