TY - JOUR
T1 - Marine Microalgae
T2 - Promising source for new bioactive compounds
AU - de Vera, Caterina R.
AU - Crespín, Guillermo Díaz
AU - Daranas, Antonio Hernández
AU - Looga, Sofia Montalvão
AU - Lillsunde, Katja Emilia
AU - Tammela, Päivi
AU - Perälä, Merja
AU - Hongisto, Vesa
AU - Virtanen, Johannes
AU - Rischer, Heiko
AU - Muller, Christian D.
AU - Norte, Manuel
AU - Fernández, José J.
AU - Souto, María L.
N1 - Funding Information:
Acknowledgments:doi:10.1021/jo50This1288mwork. was supported by the grants EU FP7-KBBE-3-245137 (MAREX), CTQ2014-55888-C03-01 (the Spanish MINECO) and by the Academy of Finland (PT, grant no. 277001). The authors thank Dr. NSaant.tRiaegv.oDFrruaggDai(sOcocve.a20n0o9g,r8a,p69h–i8c5C,deonit:r1e0.o10f3V8i/gnord,2IE48O7., Spain) for the generous gift of microalgae strains and P3i.rjo KMäaprytilnäsf,oAr.t;hVeiveiarlau,aHb.l;eGteacshpnaric,aHl a.;sSsiasntatonsc,eSi.nMthaerkheitgedh tmharoriungehppruotdauncttsicianncthereapshsaarymsaccaeruriteicdaloauntdat VTT. ConflictsofcosInterest:meceuticaThelindauthorsustries:Tdeclaripsforesunocceconflictsss.Mar.Dofruintergs201est.4,12,1066–1101,doi:10.3390/md12021066. 4. Newman,D.J.;Cragg,G.Marine-sourcedanti-cancerandcancerpaincontrolagentsinclinicalandlate preclinicaldevelopment.Mar.Drugs2014,12,255–278,doi:10.3390/md12010255. References and Note 5. Blunt,J.W.;Carroll,A.R.;Copp,B.R.;Davis,R.A.;Keyzers,R.A.;Prinset,M.R.Marinenaturalproducts.
Publisher Copyright:
© 2018 by the authors.
Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2018/9/6
Y1 - 2018/9/6
N2 - The study of marine natural products for their bioactive potential has gained strength in recent years. Oceans harbor a vast variety of organisms that offer a biological and chemical diversity with metabolic abilities unrivalled in terrestrial systems, which makes them an attractive target for bioprospecting as an almost untapped resource of biotechnological applications. Among them, there is no doubt that microalgae could become genuine “cell factories” for the biological synthesis of bioactive substances. Thus, in the course of inter-laboratory collaboration sponsored by the European Union (7th FP) into the MAREX Project focused on the discovery of novel bioactive compounds of marine origin for the European industry, a bioprospecting study on 33 microalgae strains was carried out. The strains were cultured at laboratory scale. Two extracts were prepared for each one (biomass and cell free culture medium) and, thus, screened to provide information on the antimicrobial, the anti-proliferative, and the apoptotic potential of the studied extracts. The outcome of this study provides additional scientific data for the selection of Alexadrium tamarensis WE, Gambierdiscus australes, Prorocentrum arenarium, Prorocentrum hoffmannianum, and Prorocentrum reticulatum (Pr-3) for further investigation and offers support for the continued research of new potential drugs for human therapeutics from cultured microalgae.
AB - The study of marine natural products for their bioactive potential has gained strength in recent years. Oceans harbor a vast variety of organisms that offer a biological and chemical diversity with metabolic abilities unrivalled in terrestrial systems, which makes them an attractive target for bioprospecting as an almost untapped resource of biotechnological applications. Among them, there is no doubt that microalgae could become genuine “cell factories” for the biological synthesis of bioactive substances. Thus, in the course of inter-laboratory collaboration sponsored by the European Union (7th FP) into the MAREX Project focused on the discovery of novel bioactive compounds of marine origin for the European industry, a bioprospecting study on 33 microalgae strains was carried out. The strains were cultured at laboratory scale. Two extracts were prepared for each one (biomass and cell free culture medium) and, thus, screened to provide information on the antimicrobial, the anti-proliferative, and the apoptotic potential of the studied extracts. The outcome of this study provides additional scientific data for the selection of Alexadrium tamarensis WE, Gambierdiscus australes, Prorocentrum arenarium, Prorocentrum hoffmannianum, and Prorocentrum reticulatum (Pr-3) for further investigation and offers support for the continued research of new potential drugs for human therapeutics from cultured microalgae.
KW - Bioactive compound
KW - Bioprospecting
KW - Blue biotechnology
KW - Drug discovery
KW - Marine microalgae
KW - Marine natural products
UR - http://www.scopus.com/inward/record.url?scp=85052963545&partnerID=8YFLogxK
U2 - 10.3390/md16090317
DO - 10.3390/md16090317
M3 - Article
AN - SCOPUS:85052963545
SN - 1660-3397
VL - 16
JO - Marine Drugs
JF - Marine Drugs
IS - 9
M1 - 317
ER -