Marine Microalgae

Promising source for new bioactive compounds

Caterina R. de Vera, Guillermo Díaz Crespín, Antonio Hernández Daranas, Sofia Montalvão Looga, Katja Emilia Lillsunde, Päivi Tammela, Merja Perälä, Vesa Hongisto, Johannes Virtanen, Heiko Rischer, Christian D. Muller, Manuel Norte, José J. Fernández, María L. Souto

Research output: Contribution to journalArticleScientificpeer-review

2 Citations (Scopus)

Abstract

The study of marine natural products for their bioactive potential has gained strength in recent years. Oceans harbor a vast variety of organisms that offer a biological and chemical diversity with metabolic abilities unrivalled in terrestrial systems, which makes them an attractive target for bioprospecting as an almost untapped resource of biotechnological applications. Among them, there is no doubt that microalgae could become genuine “cell factories” for the biological synthesis of bioactive substances. Thus, in the course of inter-laboratory collaboration sponsored by the European Union (7th FP) into the MAREX Project focused on the discovery of novel bioactive compounds of marine origin for the European industry, a bioprospecting study on 33 microalgae strains was carried out. The strains were cultured at laboratory scale. Two extracts were prepared for each one (biomass and cell free culture medium) and, thus, screened to provide information on the antimicrobial, the anti-proliferative, and the apoptotic potential of the studied extracts. The outcome of this study provides additional scientific data for the selection of Alexadrium tamarensis WE, Gambierdiscus australes, Prorocentrum arenarium, Prorocentrum hoffmannianum, and Prorocentrum reticulatum (Pr-3) for further investigation and offers support for the continued research of new potential drugs for human therapeutics from cultured microalgae.

Original languageEnglish
Article number317
JournalMarine Drugs
Volume16
Issue number9
DOIs
Publication statusPublished - 6 Sep 2018
MoE publication typeNot Eligible

Fingerprint

Microalgae
Biodiversity
European Union
Biological Products
Oceans and Seas
Biomass
Culture Media
Industry
Cell Culture Techniques
Outcome Assessment (Health Care)
Research
Pharmaceutical Preparations
Bioprospecting
Therapeutics

Keywords

  • Bioactive compound
  • Bioprospecting
  • Blue biotechnology
  • Drug discovery
  • Marine microalgae
  • Marine natural products

Cite this

de Vera, C. R., Crespín, G. D., Daranas, A. H., Looga, S. M., Lillsunde, K. E., Tammela, P., ... Souto, M. L. (2018). Marine Microalgae: Promising source for new bioactive compounds. Marine Drugs, 16(9), [317]. https://doi.org/10.3390/md16090317
de Vera, Caterina R. ; Crespín, Guillermo Díaz ; Daranas, Antonio Hernández ; Looga, Sofia Montalvão ; Lillsunde, Katja Emilia ; Tammela, Päivi ; Perälä, Merja ; Hongisto, Vesa ; Virtanen, Johannes ; Rischer, Heiko ; Muller, Christian D. ; Norte, Manuel ; Fernández, José J. ; Souto, María L. / Marine Microalgae : Promising source for new bioactive compounds. In: Marine Drugs. 2018 ; Vol. 16, No. 9.
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abstract = "The study of marine natural products for their bioactive potential has gained strength in recent years. Oceans harbor a vast variety of organisms that offer a biological and chemical diversity with metabolic abilities unrivalled in terrestrial systems, which makes them an attractive target for bioprospecting as an almost untapped resource of biotechnological applications. Among them, there is no doubt that microalgae could become genuine “cell factories” for the biological synthesis of bioactive substances. Thus, in the course of inter-laboratory collaboration sponsored by the European Union (7th FP) into the MAREX Project focused on the discovery of novel bioactive compounds of marine origin for the European industry, a bioprospecting study on 33 microalgae strains was carried out. The strains were cultured at laboratory scale. Two extracts were prepared for each one (biomass and cell free culture medium) and, thus, screened to provide information on the antimicrobial, the anti-proliferative, and the apoptotic potential of the studied extracts. The outcome of this study provides additional scientific data for the selection of Alexadrium tamarensis WE, Gambierdiscus australes, Prorocentrum arenarium, Prorocentrum hoffmannianum, and Prorocentrum reticulatum (Pr-3) for further investigation and offers support for the continued research of new potential drugs for human therapeutics from cultured microalgae.",
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de Vera, CR, Crespín, GD, Daranas, AH, Looga, SM, Lillsunde, KE, Tammela, P, Perälä, M, Hongisto, V, Virtanen, J, Rischer, H, Muller, CD, Norte, M, Fernández, JJ & Souto, ML 2018, 'Marine Microalgae: Promising source for new bioactive compounds', Marine Drugs, vol. 16, no. 9, 317. https://doi.org/10.3390/md16090317

Marine Microalgae : Promising source for new bioactive compounds. / de Vera, Caterina R.; Crespín, Guillermo Díaz; Daranas, Antonio Hernández; Looga, Sofia Montalvão; Lillsunde, Katja Emilia; Tammela, Päivi; Perälä, Merja; Hongisto, Vesa; Virtanen, Johannes; Rischer, Heiko; Muller, Christian D.; Norte, Manuel; Fernández, José J.; Souto, María L.

In: Marine Drugs, Vol. 16, No. 9, 317, 06.09.2018.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Marine Microalgae

T2 - Promising source for new bioactive compounds

AU - de Vera, Caterina R.

AU - Crespín, Guillermo Díaz

AU - Daranas, Antonio Hernández

AU - Looga, Sofia Montalvão

AU - Lillsunde, Katja Emilia

AU - Tammela, Päivi

AU - Perälä, Merja

AU - Hongisto, Vesa

AU - Virtanen, Johannes

AU - Rischer, Heiko

AU - Muller, Christian D.

AU - Norte, Manuel

AU - Fernández, José J.

AU - Souto, María L.

PY - 2018/9/6

Y1 - 2018/9/6

N2 - The study of marine natural products for their bioactive potential has gained strength in recent years. Oceans harbor a vast variety of organisms that offer a biological and chemical diversity with metabolic abilities unrivalled in terrestrial systems, which makes them an attractive target for bioprospecting as an almost untapped resource of biotechnological applications. Among them, there is no doubt that microalgae could become genuine “cell factories” for the biological synthesis of bioactive substances. Thus, in the course of inter-laboratory collaboration sponsored by the European Union (7th FP) into the MAREX Project focused on the discovery of novel bioactive compounds of marine origin for the European industry, a bioprospecting study on 33 microalgae strains was carried out. The strains were cultured at laboratory scale. Two extracts were prepared for each one (biomass and cell free culture medium) and, thus, screened to provide information on the antimicrobial, the anti-proliferative, and the apoptotic potential of the studied extracts. The outcome of this study provides additional scientific data for the selection of Alexadrium tamarensis WE, Gambierdiscus australes, Prorocentrum arenarium, Prorocentrum hoffmannianum, and Prorocentrum reticulatum (Pr-3) for further investigation and offers support for the continued research of new potential drugs for human therapeutics from cultured microalgae.

AB - The study of marine natural products for their bioactive potential has gained strength in recent years. Oceans harbor a vast variety of organisms that offer a biological and chemical diversity with metabolic abilities unrivalled in terrestrial systems, which makes them an attractive target for bioprospecting as an almost untapped resource of biotechnological applications. Among them, there is no doubt that microalgae could become genuine “cell factories” for the biological synthesis of bioactive substances. Thus, in the course of inter-laboratory collaboration sponsored by the European Union (7th FP) into the MAREX Project focused on the discovery of novel bioactive compounds of marine origin for the European industry, a bioprospecting study on 33 microalgae strains was carried out. The strains were cultured at laboratory scale. Two extracts were prepared for each one (biomass and cell free culture medium) and, thus, screened to provide information on the antimicrobial, the anti-proliferative, and the apoptotic potential of the studied extracts. The outcome of this study provides additional scientific data for the selection of Alexadrium tamarensis WE, Gambierdiscus australes, Prorocentrum arenarium, Prorocentrum hoffmannianum, and Prorocentrum reticulatum (Pr-3) for further investigation and offers support for the continued research of new potential drugs for human therapeutics from cultured microalgae.

KW - Bioactive compound

KW - Bioprospecting

KW - Blue biotechnology

KW - Drug discovery

KW - Marine microalgae

KW - Marine natural products

UR - http://www.scopus.com/inward/record.url?scp=85052963545&partnerID=8YFLogxK

U2 - 10.3390/md16090317

DO - 10.3390/md16090317

M3 - Article

VL - 16

JO - Marine Drugs

JF - Marine Drugs

SN - 1660-3397

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ER -

de Vera CR, Crespín GD, Daranas AH, Looga SM, Lillsunde KE, Tammela P et al. Marine Microalgae: Promising source for new bioactive compounds. Marine Drugs. 2018 Sep 6;16(9). 317. https://doi.org/10.3390/md16090317