MCNP study for epithermal neutron irradiation of an isolated liver at the Finnish BNCT facility

Research output: Contribution to journalArticleScientificpeer-review

12 Citations (Scopus)

Abstract

A successful boron neutron capture treatment (BNCT) of a patient with multiple liver metastases has been first given in Italy, by placing the removed organ into the thermal neutron column of the Triga research reactor of the University of Pavia. In Finland, FiR 1 Triga reactor with an epithermal neutron beam well suited for BNCT has been extensively used to irradiate patients with brain tumors such as glioblastoma and recently also head and neck tumors. In this work we have studied by MCNP Monte Carlo simulations, whether it would be beneficial to treat an isolated liver with epithermal neutrons instead of thermal ones. The results show, that the epithermal field penetrates deeper into the liver and creates a build-up distribution of the boron dose. Our results strongly encourage further studying of irradiation arrangement of an isolated liver with epithermal neutron fields.

Original languageEnglish
Pages (from-to)781-785
JournalApplied Radiation and Isotopes
Volume61
Issue number5
DOIs
Publication statusPublished - 1 Nov 2004
MoE publication typeA1 Journal article-refereed

Fingerprint

neutron irradiation
liver
boron
neutrons
tumors
reactors
Finland
neutron beams
metastasis
thermal neutrons
Italy
organs
brain
dosage
irradiation
simulation

Keywords

  • Epithermal irradiation
  • Liver metastases
  • MCNP
  • Triga reactor

Cite this

@article{55d504b7c44e46ee958141102862cae4,
title = "MCNP study for epithermal neutron irradiation of an isolated liver at the Finnish BNCT facility",
abstract = "A successful boron neutron capture treatment (BNCT) of a patient with multiple liver metastases has been first given in Italy, by placing the removed organ into the thermal neutron column of the Triga research reactor of the University of Pavia. In Finland, FiR 1 Triga reactor with an epithermal neutron beam well suited for BNCT has been extensively used to irradiate patients with brain tumors such as glioblastoma and recently also head and neck tumors. In this work we have studied by MCNP Monte Carlo simulations, whether it would be beneficial to treat an isolated liver with epithermal neutrons instead of thermal ones. The results show, that the epithermal field penetrates deeper into the liver and creates a build-up distribution of the boron dose. Our results strongly encourage further studying of irradiation arrangement of an isolated liver with epithermal neutron fields.",
keywords = "Epithermal irradiation, Liver metastases, MCNP, Triga reactor",
author = "Petri Kotiluoto and Iiiro Auterinen",
note = "CA2: PRO1 CA: pro_ene",
year = "2004",
month = "11",
day = "1",
doi = "10.1016/j.apradiso.2004.05.026",
language = "English",
volume = "61",
pages = "781--785",
journal = "Applied Radiation and Isotopes",
issn = "0969-8043",
publisher = "Elsevier",
number = "5",

}

MCNP study for epithermal neutron irradiation of an isolated liver at the Finnish BNCT facility. / Kotiluoto, Petri; Auterinen, Iiiro.

In: Applied Radiation and Isotopes, Vol. 61, No. 5, 01.11.2004, p. 781-785.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - MCNP study for epithermal neutron irradiation of an isolated liver at the Finnish BNCT facility

AU - Kotiluoto, Petri

AU - Auterinen, Iiiro

N1 - CA2: PRO1 CA: pro_ene

PY - 2004/11/1

Y1 - 2004/11/1

N2 - A successful boron neutron capture treatment (BNCT) of a patient with multiple liver metastases has been first given in Italy, by placing the removed organ into the thermal neutron column of the Triga research reactor of the University of Pavia. In Finland, FiR 1 Triga reactor with an epithermal neutron beam well suited for BNCT has been extensively used to irradiate patients with brain tumors such as glioblastoma and recently also head and neck tumors. In this work we have studied by MCNP Monte Carlo simulations, whether it would be beneficial to treat an isolated liver with epithermal neutrons instead of thermal ones. The results show, that the epithermal field penetrates deeper into the liver and creates a build-up distribution of the boron dose. Our results strongly encourage further studying of irradiation arrangement of an isolated liver with epithermal neutron fields.

AB - A successful boron neutron capture treatment (BNCT) of a patient with multiple liver metastases has been first given in Italy, by placing the removed organ into the thermal neutron column of the Triga research reactor of the University of Pavia. In Finland, FiR 1 Triga reactor with an epithermal neutron beam well suited for BNCT has been extensively used to irradiate patients with brain tumors such as glioblastoma and recently also head and neck tumors. In this work we have studied by MCNP Monte Carlo simulations, whether it would be beneficial to treat an isolated liver with epithermal neutrons instead of thermal ones. The results show, that the epithermal field penetrates deeper into the liver and creates a build-up distribution of the boron dose. Our results strongly encourage further studying of irradiation arrangement of an isolated liver with epithermal neutron fields.

KW - Epithermal irradiation

KW - Liver metastases

KW - MCNP

KW - Triga reactor

UR - http://www.scopus.com/inward/record.url?scp=4143147541&partnerID=8YFLogxK

U2 - 10.1016/j.apradiso.2004.05.026

DO - 10.1016/j.apradiso.2004.05.026

M3 - Article

C2 - 15308144

AN - SCOPUS:4143147541

VL - 61

SP - 781

EP - 785

JO - Applied Radiation and Isotopes

JF - Applied Radiation and Isotopes

SN - 0969-8043

IS - 5

ER -