Measurement of the change in aerosol size distribution with bacterial growth in a pilot scale fermentor

Krzysztof Szewczyk; Matti Lehtimäki; Man-Juan Pan; Usha Krishnan; Klaus Willeke; Diane Elliott; William Muth

doi:10.1002/bit.260390217

Measurement of the change in aerosol size distribution with bacterial growth in a pilot scale fermentor

Krzysztof Szewczyk, Matti Lehtimäki, Man-Juan Pan, Usha Krishnan, Klaus Willeke (Corresponding Author), Diane Elliott, William Muth

VTT Technical Research Centre of Finland

Research output: Contribution to journal › Article › Scientific › peer-review

6 Citations (Scopus)

Abstract

A number of industrial processes require the addition of materials to the fermentation broth that are hazardous to health and environment. Agitation of broths inoculated with microorganisms can potentially release aerosols large enough to carry the microorganisms. The influence of agitation, air flow, and bacterial growth on aerosol size distribution, air flow, and bacterial growth on aerosol size distribution was investigated in an industrial pilot scale fermentor. A decrease in particle concentration was observed with increase in bacterial growth; this change was more pronounced in the size range above 2 μm. The aerosol size distribution was found to be practically independent of air flow rate and agitation rate for sizes less than 2 μm. However, for particles largar than 2 μm, the concentration was found to increase with an increase in air flow rate and agitation rate.

Original language	English
Pages (from-to)	243-245
Journal	Biotechnology and Bioengineering
Volume	39
Issue number	2
DOIs	https://doi.org/10.1002/bit.260390217
Publication status	Published - 1992
MoE publication type	A1 Journal article-refereed

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abstract = "A number of industrial processes require the addition of materials to the fermentation broth that are hazardous to health and environment. Agitation of broths inoculated with microorganisms can potentially release aerosols large enough to carry the microorganisms. The influence of agitation, air flow, and bacterial growth on aerosol size distribution, air flow, and bacterial growth on aerosol size distribution was investigated in an industrial pilot scale fermentor. A decrease in particle concentration was observed with increase in bacterial growth; this change was more pronounced in the size range above 2 μm. The aerosol size distribution was found to be practically independent of air flow rate and agitation rate for sizes less than 2 μm. However, for particles largar than 2 μm, the concentration was found to increase with an increase in air flow rate and agitation rate.",

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AU - Szewczyk, Krzysztof

AU - Lehtimäki, Matti

AU - Pan, Man-Juan

AU - Krishnan, Usha

AU - Willeke, Klaus

AU - Elliott, Diane

AU - Muth, William

PY - 1992

Y1 - 1992

N2 - A number of industrial processes require the addition of materials to the fermentation broth that are hazardous to health and environment. Agitation of broths inoculated with microorganisms can potentially release aerosols large enough to carry the microorganisms. The influence of agitation, air flow, and bacterial growth on aerosol size distribution, air flow, and bacterial growth on aerosol size distribution was investigated in an industrial pilot scale fermentor. A decrease in particle concentration was observed with increase in bacterial growth; this change was more pronounced in the size range above 2 μm. The aerosol size distribution was found to be practically independent of air flow rate and agitation rate for sizes less than 2 μm. However, for particles largar than 2 μm, the concentration was found to increase with an increase in air flow rate and agitation rate.

AB - A number of industrial processes require the addition of materials to the fermentation broth that are hazardous to health and environment. Agitation of broths inoculated with microorganisms can potentially release aerosols large enough to carry the microorganisms. The influence of agitation, air flow, and bacterial growth on aerosol size distribution, air flow, and bacterial growth on aerosol size distribution was investigated in an industrial pilot scale fermentor. A decrease in particle concentration was observed with increase in bacterial growth; this change was more pronounced in the size range above 2 μm. The aerosol size distribution was found to be practically independent of air flow rate and agitation rate for sizes less than 2 μm. However, for particles largar than 2 μm, the concentration was found to increase with an increase in air flow rate and agitation rate.

U2 - 10.1002/bit.260390217

DO - 10.1002/bit.260390217

M3 - Article

SN - 0006-3592

VL - 39

SP - 243

EP - 245

JO - Biotechnology and Bioengineering

JF - Biotechnology and Bioengineering

IS - 2

ER -

Measurement of the change in aerosol size distribution with bacterial growth in a pilot scale fermentor

Abstract

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