Measurements of glucose content in scattering media with time-of-flight technique: comparison with Monte Carlo simulations

Matti Kinnunen, Alexey Popov, Jerzy Pluciński, Risto Myllylä, Alexander V. Priezzhev

Research output: Chapter in Book/Report/Conference proceedingConference article in proceedingsScientificpeer-review

20 Citations (Scopus)


Scattering effect of the media can be seen as a pulse broadening and time delay of the pulse maximum relatively to the initial pulse. The purpose of this paper is to study the applicability of the time-of-flight measurement technique for glucose detection in 2% Intralipid™ solutions in vitro. Glucose samples with concentrations of 100, 200, 300, 500, 1000, 2000, 4000, and 8000 mg/dl are studied. Laser pulses with λ = 906 nm and FWHM = 30 ps are used in the experiments to investigate scattering properties of Intralipid™ 1 - 5% Intralipid™ suspensions are used to simulate scattering properties of different skin layers in the NIR spectrum region. Measurements are conducted with a slab cuvette, with 300-μm step index type fibers, and with 100-μm gradient index type fibers. Light propagation in the aqueous solutions is also studied by the Monte Carlo simulation. The simulations and the measurement results seem to correlate quite well for Intralipid suspensions. A clear correlation of pulse parameters as a function of Intralipid™ concentration was found. Slight changes of time delays of pulse maxima and the pulse broadening as a function of glucose concentration were revealed. Gradient index type fibers are found to be better choice for sensing glucose than the step index type fibers.

Original languageEnglish
Title of host publicationSaratov Fall Meeting 2003
Subtitle of host publicationOptical Technologies in Biophysics and Medicine V
EditorsValery V. Tuchin
PublisherInternational Society for Optics and Photonics SPIE
ISBN (Print)978-0-8194-5397-6
Publication statusPublished - 1 Dec 2004
MoE publication typeA4 Article in a conference publication
EventSaratov Fall Meeting 2003: Optical Technologies in Biophysics and Medicine V - Saratov, Russian Federation
Duration: 7 Oct 200310 Oct 2003

Publication series

SeriesProgress in Biomedical Optics and Imaging
SeriesProceedings of SPIE


WorkshopSaratov Fall Meeting 2003
Country/TerritoryRussian Federation


  • Glucose
  • Intralipid™
  • Optical fiber
  • Time-of-flight


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