Mechanisms and regulation of epithelial Ca2+ absorption in health and disease

Yoshiro Suzuki, Christopher P Landowski, Matthias A Hediger (Corresponding Author)

Research output: Contribution to journalReview ArticleScientificpeer-review

58 Citations (Scopus)

Abstract

Ca2+ is essential for numerous physiological functions in our bodies. Therefore, its homeostasis is finely maintained through the coordination of intestinal absorption, renal reabsorption, and bone resorption. The Ca2+-selective epithelial channels TRPV5 and TRPV6 have been identified, and their physiological roles have been revealed: TRPV5 is important in final renal Ca2+ reabsorption, and TRPV6 has a key role in intestinal Ca2+ absorption. The TRPV5 knockout mice exhibit renal leak hypercalciuria and accordingly upregulate their intestinal TRPV6 expression to compensate for their negative Ca2+ balance. In contrast, despite their severe negative Ca2+ balance, TRPV6-null mice do not display any compensatory mechanism, thus resulting in secondary hyperparathyroidism. These results indicate that the genes for TRPV5 and TRPV6 are differentially regulated in human diseases associated with disturbed Ca2+ balance such as hypercalciuria, osteoporosis, and vitamin D-resistant rickets.

Original languageEnglish
Pages (from-to)257-71
Number of pages15
JournalAnnual Review of Physiology
Volume70
DOIs
Publication statusPublished - 2008
MoE publication typeA2 Review article in a scientific journal

Fingerprint

Hypercalciuria
Intestinal Absorption
Hypophosphatemic Rickets
Secondary Hyperparathyroidism
Health
Bone Resorption
Knockout Mice
Osteoporosis
Homeostasis
Up-Regulation
Kidney
Genes
Renal Reabsorption
TRPV6 channel

Keywords

  • Animals
  • Bone Diseases, Metabolic/metabolism
  • Calcium/metabolism
  • Epithelium/metabolism
  • Homeostasis/physiology
  • Humans
  • Hypercalciuria/metabolism
  • Intestinal Absorption/physiology
  • TRPV Cation Channels/metabolism

Cite this

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title = "Mechanisms and regulation of epithelial Ca2+ absorption in health and disease",
abstract = "Ca2+ is essential for numerous physiological functions in our bodies. Therefore, its homeostasis is finely maintained through the coordination of intestinal absorption, renal reabsorption, and bone resorption. The Ca2+-selective epithelial channels TRPV5 and TRPV6 have been identified, and their physiological roles have been revealed: TRPV5 is important in final renal Ca2+ reabsorption, and TRPV6 has a key role in intestinal Ca2+ absorption. The TRPV5 knockout mice exhibit renal leak hypercalciuria and accordingly upregulate their intestinal TRPV6 expression to compensate for their negative Ca2+ balance. In contrast, despite their severe negative Ca2+ balance, TRPV6-null mice do not display any compensatory mechanism, thus resulting in secondary hyperparathyroidism. These results indicate that the genes for TRPV5 and TRPV6 are differentially regulated in human diseases associated with disturbed Ca2+ balance such as hypercalciuria, osteoporosis, and vitamin D-resistant rickets.",
keywords = "Animals, Bone Diseases, Metabolic/metabolism, Calcium/metabolism, Epithelium/metabolism, Homeostasis/physiology, Humans, Hypercalciuria/metabolism, Intestinal Absorption/physiology, TRPV Cation Channels/metabolism",
author = "Yoshiro Suzuki and Landowski, {Christopher P} and Hediger, {Matthias A}",
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language = "English",
volume = "70",
pages = "257--71",
journal = "Annual Review of Physiology",
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Mechanisms and regulation of epithelial Ca2+ absorption in health and disease. / Suzuki, Yoshiro; Landowski, Christopher P; Hediger, Matthias A (Corresponding Author).

In: Annual Review of Physiology, Vol. 70, 2008, p. 257-71.

Research output: Contribution to journalReview ArticleScientificpeer-review

TY - JOUR

T1 - Mechanisms and regulation of epithelial Ca2+ absorption in health and disease

AU - Suzuki, Yoshiro

AU - Landowski, Christopher P

AU - Hediger, Matthias A

PY - 2008

Y1 - 2008

N2 - Ca2+ is essential for numerous physiological functions in our bodies. Therefore, its homeostasis is finely maintained through the coordination of intestinal absorption, renal reabsorption, and bone resorption. The Ca2+-selective epithelial channels TRPV5 and TRPV6 have been identified, and their physiological roles have been revealed: TRPV5 is important in final renal Ca2+ reabsorption, and TRPV6 has a key role in intestinal Ca2+ absorption. The TRPV5 knockout mice exhibit renal leak hypercalciuria and accordingly upregulate their intestinal TRPV6 expression to compensate for their negative Ca2+ balance. In contrast, despite their severe negative Ca2+ balance, TRPV6-null mice do not display any compensatory mechanism, thus resulting in secondary hyperparathyroidism. These results indicate that the genes for TRPV5 and TRPV6 are differentially regulated in human diseases associated with disturbed Ca2+ balance such as hypercalciuria, osteoporosis, and vitamin D-resistant rickets.

AB - Ca2+ is essential for numerous physiological functions in our bodies. Therefore, its homeostasis is finely maintained through the coordination of intestinal absorption, renal reabsorption, and bone resorption. The Ca2+-selective epithelial channels TRPV5 and TRPV6 have been identified, and their physiological roles have been revealed: TRPV5 is important in final renal Ca2+ reabsorption, and TRPV6 has a key role in intestinal Ca2+ absorption. The TRPV5 knockout mice exhibit renal leak hypercalciuria and accordingly upregulate their intestinal TRPV6 expression to compensate for their negative Ca2+ balance. In contrast, despite their severe negative Ca2+ balance, TRPV6-null mice do not display any compensatory mechanism, thus resulting in secondary hyperparathyroidism. These results indicate that the genes for TRPV5 and TRPV6 are differentially regulated in human diseases associated with disturbed Ca2+ balance such as hypercalciuria, osteoporosis, and vitamin D-resistant rickets.

KW - Animals

KW - Bone Diseases, Metabolic/metabolism

KW - Calcium/metabolism

KW - Epithelium/metabolism

KW - Homeostasis/physiology

KW - Humans

KW - Hypercalciuria/metabolism

KW - Intestinal Absorption/physiology

KW - TRPV Cation Channels/metabolism

U2 - 10.1146/annurev.physiol.69.031905.161003

DO - 10.1146/annurev.physiol.69.031905.161003

M3 - Review Article

C2 - 17850211

VL - 70

SP - 257

EP - 271

JO - Annual Review of Physiology

JF - Annual Review of Physiology

SN - 0066-4278

ER -