Mechanisms and regulation of epithelial Ca2+ absorption in health and disease

Yoshiro Suzuki, Christopher P Landowski, Matthias A Hediger (Corresponding Author)

Research output: Contribution to journalReview ArticleScientificpeer-review

66 Citations (Scopus)

Abstract

Ca2+ is essential for numerous physiological functions in our bodies. Therefore, its homeostasis is finely maintained through the coordination of intestinal absorption, renal reabsorption, and bone resorption. The Ca2+-selective epithelial channels TRPV5 and TRPV6 have been identified, and their physiological roles have been revealed: TRPV5 is important in final renal Ca2+ reabsorption, and TRPV6 has a key role in intestinal Ca2+ absorption. The TRPV5 knockout mice exhibit renal leak hypercalciuria and accordingly upregulate their intestinal TRPV6 expression to compensate for their negative Ca2+ balance. In contrast, despite their severe negative Ca2+ balance, TRPV6-null mice do not display any compensatory mechanism, thus resulting in secondary hyperparathyroidism. These results indicate that the genes for TRPV5 and TRPV6 are differentially regulated in human diseases associated with disturbed Ca2+ balance such as hypercalciuria, osteoporosis, and vitamin D-resistant rickets.

Original languageEnglish
Pages (from-to)257-71
Number of pages15
JournalAnnual Review of Physiology
Volume70
DOIs
Publication statusPublished - 2008
MoE publication typeA2 Review article in a scientific journal

Keywords

  • Animals
  • Bone Diseases, Metabolic/metabolism
  • Calcium/metabolism
  • Epithelium/metabolism
  • Homeostasis/physiology
  • Humans
  • Hypercalciuria/metabolism
  • Intestinal Absorption/physiology
  • TRPV Cation Channels/metabolism

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