Mechanistic and dose considerations for supporting adverse pulmonary physiology in response to formaldehyde

Chad M. Thompson (Corresponding Author), Ravi P. Subramaniam, Roland Grafström

Research output: Contribution to journalArticleScientificpeer-review

22 Citations (Scopus)

Abstract

Induction of airway hyperresponsiveness and asthma from formaldehyde inhalation exposure remains a debated and controversial issue. Yet, recent evidences on pulmonary biology and the pharmacokinetics and toxicity of formaldehyde lend support for such adverse effects. Specifically, altered thiol biology from accelerated enzymatic reduction of the endogenous bronchodilator S-nitrosoglutathione and pulmonary inflammation from involvement of Th2-mediated immune responses might serve as key events and cooperate in airway pathophysiology.

Understanding what role these mechanisms play in various species and lifestages (e.g., child vs. adult) could be crucial for making more meaningful inter- and intra-species dosimetric extrapolations in human health risk assessment.
Original languageEnglish
Pages (from-to)355-359
JournalToxicology and Applied Pharmacology
Volume233
Issue number3
DOIs
Publication statusPublished - 2008
MoE publication typeA1 Journal article-refereed

Fingerprint

Physiology
Formaldehyde
S-Nitrosoglutathione
Inhalation Exposure
Lung
Pharmacokinetics
Health risks
Bronchodilator Agents
Sulfhydryl Compounds
Extrapolation
Risk assessment
Toxicity
Pneumonia
Asthma
Health
Formaldehyde poisoning

Keywords

  • Formaldehyde
  • Asthma
  • S-nitrosoglutathione
  • Dosimetry
  • ADH3

Cite this

Thompson, Chad M. ; Subramaniam, Ravi P. ; Grafström, Roland. / Mechanistic and dose considerations for supporting adverse pulmonary physiology in response to formaldehyde. In: Toxicology and Applied Pharmacology. 2008 ; Vol. 233, No. 3. pp. 355-359.
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Mechanistic and dose considerations for supporting adverse pulmonary physiology in response to formaldehyde. / Thompson, Chad M. (Corresponding Author); Subramaniam, Ravi P.; Grafström, Roland.

In: Toxicology and Applied Pharmacology, Vol. 233, No. 3, 2008, p. 355-359.

Research output: Contribution to journalArticleScientificpeer-review

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