Membrane proteins diffuse as dynamic complexes with lipids

Perttu Niemelä, Markus S. Miettinen, Luca Monticelli, Henrik Hammaren, Pär Bjelkmar, Teemu Murtola, Erik Lindahl, Ilpo Vattulainen (Corresponding Author)

Research output: Contribution to journalArticleScientificpeer-review

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Abstract

We describe how membrane proteins diffuse laterally in the membrane plane together with the lipids surrounding them. We find a number of intriguing phenomena. The lateral displacements of the protein and the lipids are strongly correlated, as the protein and the neighboring lipids form a dynamical protein−lipid complex, consisting of ∼50−100 lipids. The diffusion of the lipids in the complex is much slower compared to the rest of the lipids. We also find a strong directional correlation between the movements of the protein and the lipids in its vicinity. The results imply that in crowded membrane environments there are no “free” lipids, as they are all influenced by the protein structure and dynamics. Our results indicate that, in studies of cell membranes, protein and lipid dynamics have to be considered together.
Original languageEnglish
Pages (from-to)7574-7575
JournalJournal of the American Chemical Society
Volume132
Issue number22
DOIs
Publication statusPublished - 2010
MoE publication typeA1 Journal article-refereed

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Lipids
Membrane Proteins
Proteins
Membranes
Membrane Lipids
Cell membranes

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Niemelä, P., Miettinen, M. S., Monticelli, L., Hammaren, H., Bjelkmar, P., Murtola, T., ... Vattulainen, I. (2010). Membrane proteins diffuse as dynamic complexes with lipids. Journal of the American Chemical Society, 132(22), 7574-7575. https://doi.org/10.1021/ja101481b
Niemelä, Perttu ; Miettinen, Markus S. ; Monticelli, Luca ; Hammaren, Henrik ; Bjelkmar, Pär ; Murtola, Teemu ; Lindahl, Erik ; Vattulainen, Ilpo. / Membrane proteins diffuse as dynamic complexes with lipids. In: Journal of the American Chemical Society. 2010 ; Vol. 132, No. 22. pp. 7574-7575.
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abstract = "We describe how membrane proteins diffuse laterally in the membrane plane together with the lipids surrounding them. We find a number of intriguing phenomena. The lateral displacements of the protein and the lipids are strongly correlated, as the protein and the neighboring lipids form a dynamical protein−lipid complex, consisting of ∼50−100 lipids. The diffusion of the lipids in the complex is much slower compared to the rest of the lipids. We also find a strong directional correlation between the movements of the protein and the lipids in its vicinity. The results imply that in crowded membrane environments there are no “free” lipids, as they are all influenced by the protein structure and dynamics. Our results indicate that, in studies of cell membranes, protein and lipid dynamics have to be considered together.",
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Niemelä, P, Miettinen, MS, Monticelli, L, Hammaren, H, Bjelkmar, P, Murtola, T, Lindahl, E & Vattulainen, I 2010, 'Membrane proteins diffuse as dynamic complexes with lipids', Journal of the American Chemical Society, vol. 132, no. 22, pp. 7574-7575. https://doi.org/10.1021/ja101481b

Membrane proteins diffuse as dynamic complexes with lipids. / Niemelä, Perttu; Miettinen, Markus S.; Monticelli, Luca; Hammaren, Henrik; Bjelkmar, Pär; Murtola, Teemu; Lindahl, Erik; Vattulainen, Ilpo (Corresponding Author).

In: Journal of the American Chemical Society, Vol. 132, No. 22, 2010, p. 7574-7575.

Research output: Contribution to journalArticleScientificpeer-review

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AU - Niemelä, Perttu

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AU - Monticelli, Luca

AU - Hammaren, Henrik

AU - Bjelkmar, Pär

AU - Murtola, Teemu

AU - Lindahl, Erik

AU - Vattulainen, Ilpo

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AB - We describe how membrane proteins diffuse laterally in the membrane plane together with the lipids surrounding them. We find a number of intriguing phenomena. The lateral displacements of the protein and the lipids are strongly correlated, as the protein and the neighboring lipids form a dynamical protein−lipid complex, consisting of ∼50−100 lipids. The diffusion of the lipids in the complex is much slower compared to the rest of the lipids. We also find a strong directional correlation between the movements of the protein and the lipids in its vicinity. The results imply that in crowded membrane environments there are no “free” lipids, as they are all influenced by the protein structure and dynamics. Our results indicate that, in studies of cell membranes, protein and lipid dynamics have to be considered together.

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Niemelä P, Miettinen MS, Monticelli L, Hammaren H, Bjelkmar P, Murtola T et al. Membrane proteins diffuse as dynamic complexes with lipids. Journal of the American Chemical Society. 2010;132(22):7574-7575. https://doi.org/10.1021/ja101481b