Metabolic engineering of plant cells using SOLUCEL technology

Research output: Chapter in Book/Report/Conference proceedingConference article in proceedingsScientificpeer-review

Abstract

SOLUCEL technology is based on the current advancement in understanding plant genomes, and on the development of novel tools for high throughput selecting and testing genes involved in the production of plant secondary metabolites. It can be applied (i) to enhance the production of marketed high-value pharmaceuticals in plant cell cultures (ii) to develop reliable and reproducible sources of plant-derived molecules with potential pharmaceutical value, and (iii) to increase the chemical diversity of plant based molecules through Combinatorial Biochemistry. We have developed this technology using the nicotine alkaloid biosynthesis pathway as a model system. A few examples will be given of how overexpressing some novel genes can be used either to tailor cell cultures to enhance the production of nicotine alkaloids or to direct biosynthetic pathways in related plant species. Furthermore, these novel genes may play an important role in secondary metabolism as master regulators in general.
Original languageEnglish
Title of host publicationSupplement Plant and Cell Physiology
Volume45
DOIs
Publication statusPublished - 2004
MoE publication typeNot Eligible
Event45th Annual Meeting of the Japanese Society of Plant Physiologists, JSPP - Tokyo, Japan
Duration: 27 Mar 200429 Mar 2004
Conference number: 45

Conference

Conference45th Annual Meeting of the Japanese Society of Plant Physiologists, JSPP
Abbreviated titleJSPP
CountryJapan
CityTokyo
Period27/03/0429/03/04

Fingerprint

metabolic engineering
nicotine
cells
alkaloids
cell culture
drugs
genes
biochemistry
secondary metabolites
biochemical pathways
biosynthesis
metabolism
genome
testing

Cite this

Oksman-Caldentey, Kirsi-Marja ; Inze, Dirk. / Metabolic engineering of plant cells using SOLUCEL technology. Supplement Plant and Cell Physiology. Vol. 45 2004.
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title = "Metabolic engineering of plant cells using SOLUCEL technology",
abstract = "SOLUCEL technology is based on the current advancement in understanding plant genomes, and on the development of novel tools for high throughput selecting and testing genes involved in the production of plant secondary metabolites. It can be applied (i) to enhance the production of marketed high-value pharmaceuticals in plant cell cultures (ii) to develop reliable and reproducible sources of plant-derived molecules with potential pharmaceutical value, and (iii) to increase the chemical diversity of plant based molecules through Combinatorial Biochemistry. We have developed this technology using the nicotine alkaloid biosynthesis pathway as a model system. A few examples will be given of how overexpressing some novel genes can be used either to tailor cell cultures to enhance the production of nicotine alkaloids or to direct biosynthetic pathways in related plant species. Furthermore, these novel genes may play an important role in secondary metabolism as master regulators in general.",
author = "Kirsi-Marja Oksman-Caldentey and Dirk Inze",
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Oksman-Caldentey, K-M & Inze, D 2004, Metabolic engineering of plant cells using SOLUCEL technology. in Supplement Plant and Cell Physiology. vol. 45, S032, 45th Annual Meeting of the Japanese Society of Plant Physiologists, JSPP, Tokyo, Japan, 27/03/04. https://doi.org/10.14841/jspp.2004.0.S032.0

Metabolic engineering of plant cells using SOLUCEL technology. / Oksman-Caldentey, Kirsi-Marja; Inze, Dirk.

Supplement Plant and Cell Physiology. Vol. 45 2004. S032.

Research output: Chapter in Book/Report/Conference proceedingConference article in proceedingsScientificpeer-review

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N2 - SOLUCEL technology is based on the current advancement in understanding plant genomes, and on the development of novel tools for high throughput selecting and testing genes involved in the production of plant secondary metabolites. It can be applied (i) to enhance the production of marketed high-value pharmaceuticals in plant cell cultures (ii) to develop reliable and reproducible sources of plant-derived molecules with potential pharmaceutical value, and (iii) to increase the chemical diversity of plant based molecules through Combinatorial Biochemistry. We have developed this technology using the nicotine alkaloid biosynthesis pathway as a model system. A few examples will be given of how overexpressing some novel genes can be used either to tailor cell cultures to enhance the production of nicotine alkaloids or to direct biosynthetic pathways in related plant species. Furthermore, these novel genes may play an important role in secondary metabolism as master regulators in general.

AB - SOLUCEL technology is based on the current advancement in understanding plant genomes, and on the development of novel tools for high throughput selecting and testing genes involved in the production of plant secondary metabolites. It can be applied (i) to enhance the production of marketed high-value pharmaceuticals in plant cell cultures (ii) to develop reliable and reproducible sources of plant-derived molecules with potential pharmaceutical value, and (iii) to increase the chemical diversity of plant based molecules through Combinatorial Biochemistry. We have developed this technology using the nicotine alkaloid biosynthesis pathway as a model system. A few examples will be given of how overexpressing some novel genes can be used either to tailor cell cultures to enhance the production of nicotine alkaloids or to direct biosynthetic pathways in related plant species. Furthermore, these novel genes may play an important role in secondary metabolism as master regulators in general.

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