Metabolic engineering of plant secondary products

Which way forward?

B. Miralpeix, Heiko Rischer, Suvi Häkkinen, Anneli Ritala, Tuulilkki Seppänen-Laakso, Kirsi-Marja Oksman-Caldentey, T. Capell, P. Christou

Research output: Contribution to journalArticleScientificpeer-review

23 Citations (Scopus)

Abstract

Secondary products are small molecular weight compounds produced by secondary metabolic pathways in plants. They are regarded as non-essential for normal growth and development but often confer benefits such as defense against pathogens, pests and herbivores or the attraction of pollinators. Many secondary products affect the survival and/or behavior of microbes, insects and mammals and they often have useful pharmacological effects in humans. Most secondary products can only be obtained as extracts from medicinal plants, many of which grow slowly and are difficult to cultivate. Chemical synthesis, although possible in principle, is often impractical or uneconomical due to the complexity of their molecular structures. The large scale production of secondary products by metabolic engineering has therefore been investigated in a number of heterologous systems including microbes, plant cell/organ cultures, and intact plants. In this critical review of production platforms for plant secondary products, we discuss the advantages and constraints of different approaches and the impact of post-genomics technologies on gene discovery and metabolite analysis. We highlight bottlenecks that remain to be overcome before the routine exploitation of secondary products can be achieved for the benefit of mankind.
Original languageEnglish
Pages (from-to)5622-5639
Number of pages17
JournalCurrent Pharmaceutical Design
Volume19
Issue number31
DOIs
Publication statusPublished - 2013
MoE publication typeA1 Journal article-refereed

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Metabolic Engineering
Herbivory
Organ Culture Techniques
Plant Cells
Genetic Association Studies
Medicinal Plants
Genomics
Metabolic Networks and Pathways
Molecular Structure
Growth and Development
Insects
Mammals
Cell Culture Techniques
Molecular Weight
Pharmacology
Technology
Survival

Keywords

  • metabolic engineering
  • microbes
  • plant cell culture
  • post-genomics technologies
  • secondary metabolites
  • transgenic plants

Cite this

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title = "Metabolic engineering of plant secondary products: Which way forward?",
abstract = "Secondary products are small molecular weight compounds produced by secondary metabolic pathways in plants. They are regarded as non-essential for normal growth and development but often confer benefits such as defense against pathogens, pests and herbivores or the attraction of pollinators. Many secondary products affect the survival and/or behavior of microbes, insects and mammals and they often have useful pharmacological effects in humans. Most secondary products can only be obtained as extracts from medicinal plants, many of which grow slowly and are difficult to cultivate. Chemical synthesis, although possible in principle, is often impractical or uneconomical due to the complexity of their molecular structures. The large scale production of secondary products by metabolic engineering has therefore been investigated in a number of heterologous systems including microbes, plant cell/organ cultures, and intact plants. In this critical review of production platforms for plant secondary products, we discuss the advantages and constraints of different approaches and the impact of post-genomics technologies on gene discovery and metabolite analysis. We highlight bottlenecks that remain to be overcome before the routine exploitation of secondary products can be achieved for the benefit of mankind.",
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Metabolic engineering of plant secondary products : Which way forward? / Miralpeix, B.; Rischer, Heiko; Häkkinen, Suvi; Ritala, Anneli; Seppänen-Laakso, Tuulilkki; Oksman-Caldentey, Kirsi-Marja; Capell, T.; Christou, P.

In: Current Pharmaceutical Design, Vol. 19, No. 31, 2013, p. 5622-5639.

Research output: Contribution to journalArticleScientificpeer-review

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T2 - Which way forward?

AU - Miralpeix, B.

AU - Rischer, Heiko

AU - Häkkinen, Suvi

AU - Ritala, Anneli

AU - Seppänen-Laakso, Tuulilkki

AU - Oksman-Caldentey, Kirsi-Marja

AU - Capell, T.

AU - Christou, P.

PY - 2013

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N2 - Secondary products are small molecular weight compounds produced by secondary metabolic pathways in plants. They are regarded as non-essential for normal growth and development but often confer benefits such as defense against pathogens, pests and herbivores or the attraction of pollinators. Many secondary products affect the survival and/or behavior of microbes, insects and mammals and they often have useful pharmacological effects in humans. Most secondary products can only be obtained as extracts from medicinal plants, many of which grow slowly and are difficult to cultivate. Chemical synthesis, although possible in principle, is often impractical or uneconomical due to the complexity of their molecular structures. The large scale production of secondary products by metabolic engineering has therefore been investigated in a number of heterologous systems including microbes, plant cell/organ cultures, and intact plants. In this critical review of production platforms for plant secondary products, we discuss the advantages and constraints of different approaches and the impact of post-genomics technologies on gene discovery and metabolite analysis. We highlight bottlenecks that remain to be overcome before the routine exploitation of secondary products can be achieved for the benefit of mankind.

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