Metabolome and fecal microbiota in monozygotic twin pairs discordant for weight: A Big Mac challenge

I Bondia-Pons, Johanna Maukonen, Ismo Mattila, A Rissanen, Maria Saarela, J Kaprio, A Hakkarainen, J Lundbom, N Lundbom, T Hyötyläinen, K H Pietiläinen, M Oresic

Research output: Contribution to journalArticleScientificpeer-review

17 Citations (Scopus)


Postprandial responses to food are complex, involving both genetic and environmental factors. We studied postprandial responses to a Big Mac meal challenge in monozygotic co-twins highly discordant for body weight. This unique design allows assessment of the contribution of obesity, independent of genetic liability. Comprehensive metabolic profiling using 3 analytical platforms was applied to fasting and postprandial serum samples from 16 healthy monozygotic twin pairs discordant for weight (body mass index difference >3 kg/m2). Nine concordant monozygotic pairs were examined as control pairs. Fecal samples were analyzed to assess diversity of the major bacterial groups by using 5 different validated bacterial group specific denaturing gradient gel electrophoresis methods. No differences in fecal bacterial diversity were detected when comparing co-twins discordant for weight (ANOVA, P
Original languageEnglish
Pages (from-to)4169-4179
Number of pages10
JournalFASEB Journal
Issue number9
Publication statusPublished - 2014
MoE publication typeA1 Journal article-refereed


  • Obesity
  • metabolomics
  • bile acids

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