Metabolomic analysis of plasma metabolites that may mediate effects of rye bread on satiety and weight maintenance in postmenopausal women

Maria Lankinen (Corresponding Author), Ursula Schwab, Tuulikki Seppänen-Laakso, Ismo Mattila, Katri Juntunen, Hannu Mykkänen, Kaisa Poutanen, Helena Gylling, Matej Orešič

Research output: Contribution to journalArticleScientificpeer-review

36 Citations (Scopus)

Abstract

The evidence of the beneficial health effects of dietary fiber and whole grain consumption is strong, but the underlying mechanisms are not completely understood. Here, we investigate how the consumption of high-fiber rye bread (RB) or white-wheat bread (WB) modifies the plasma metabolomic profiles in postmenopausal women. The study was a randomized crossover trial consisting of 8-wk intervention periods and an 8-wk washout period. The study included 39 postmenopausal women with elevated serum total cholesterol (5.0–8.5 mmol/L) and BMI 20–33 kg/m2. During the intervention periods, the study breads contributed to least 20% of total energy intake. Two analytical platforms for metabolomics were applied. Lipidomic analysis was performed using ultra performance liquid chromatography coupled to electrospray ionization MS and the other metabolites, including sterols, organic acids, and alcohols, were analyzed by 2-dimensional GC coupled to time-of-flight MS. Altogether, 540 metabolites were profiled. Ribitol (P < 0.001), ribonic acid (P < 0.001), and indoleacetic acid (P < 0.001) increased during the RB consumption period. Ribonic acid correlated positively with tryptophan (r = 0.40; P = 0.003), which is a precursor for the biosynthesis of hunger-depressing serotonin. There were no changes in plasma lipidomic profiles during the RB or WB intervention periods. The results suggest that 8-wk consumption of high-fiber rye bread increases metabolites that might mediate positive effects of rye bread on satiety and weight maintenance.
Original languageEnglish
Pages (from-to)31-36
Number of pages6
JournalJournal of Nutrition
Volume141
Issue number1
DOIs
Publication statusPublished - 2010
MoE publication typeA1 Journal article-refereed

Fingerprint

Metabolomics
Bread
Maintenance
Weights and Measures
Triticum
Acids
Ribitol
Hunger
Secale
Dietary Fiber
Sterols
Energy Intake
Tryptophan
Liquid Chromatography
Cross-Over Studies
Serotonin
Cholesterol
Alcohols
Health
Serum

Cite this

Lankinen, Maria ; Schwab, Ursula ; Seppänen-Laakso, Tuulikki ; Mattila, Ismo ; Juntunen, Katri ; Mykkänen, Hannu ; Poutanen, Kaisa ; Gylling, Helena ; Orešič, Matej. / Metabolomic analysis of plasma metabolites that may mediate effects of rye bread on satiety and weight maintenance in postmenopausal women. In: Journal of Nutrition. 2010 ; Vol. 141, No. 1. pp. 31-36.
@article{616544ba058a4ba385d28cf6d6d6dde4,
title = "Metabolomic analysis of plasma metabolites that may mediate effects of rye bread on satiety and weight maintenance in postmenopausal women",
abstract = "The evidence of the beneficial health effects of dietary fiber and whole grain consumption is strong, but the underlying mechanisms are not completely understood. Here, we investigate how the consumption of high-fiber rye bread (RB) or white-wheat bread (WB) modifies the plasma metabolomic profiles in postmenopausal women. The study was a randomized crossover trial consisting of 8-wk intervention periods and an 8-wk washout period. The study included 39 postmenopausal women with elevated serum total cholesterol (5.0–8.5 mmol/L) and BMI 20–33 kg/m2. During the intervention periods, the study breads contributed to least 20{\%} of total energy intake. Two analytical platforms for metabolomics were applied. Lipidomic analysis was performed using ultra performance liquid chromatography coupled to electrospray ionization MS and the other metabolites, including sterols, organic acids, and alcohols, were analyzed by 2-dimensional GC coupled to time-of-flight MS. Altogether, 540 metabolites were profiled. Ribitol (P < 0.001), ribonic acid (P < 0.001), and indoleacetic acid (P < 0.001) increased during the RB consumption period. Ribonic acid correlated positively with tryptophan (r = 0.40; P = 0.003), which is a precursor for the biosynthesis of hunger-depressing serotonin. There were no changes in plasma lipidomic profiles during the RB or WB intervention periods. The results suggest that 8-wk consumption of high-fiber rye bread increases metabolites that might mediate positive effects of rye bread on satiety and weight maintenance.",
author = "Maria Lankinen and Ursula Schwab and Tuulikki Sepp{\"a}nen-Laakso and Ismo Mattila and Katri Juntunen and Hannu Mykk{\"a}nen and Kaisa Poutanen and Helena Gylling and Matej Orešič",
year = "2010",
doi = "10.3945/jn.110.131656",
language = "English",
volume = "141",
pages = "31--36",
journal = "Journal of Nutrition",
issn = "0022-3166",
number = "1",

}

Metabolomic analysis of plasma metabolites that may mediate effects of rye bread on satiety and weight maintenance in postmenopausal women. / Lankinen, Maria (Corresponding Author); Schwab, Ursula; Seppänen-Laakso, Tuulikki; Mattila, Ismo; Juntunen, Katri; Mykkänen, Hannu; Poutanen, Kaisa; Gylling, Helena; Orešič, Matej.

In: Journal of Nutrition, Vol. 141, No. 1, 2010, p. 31-36.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Metabolomic analysis of plasma metabolites that may mediate effects of rye bread on satiety and weight maintenance in postmenopausal women

AU - Lankinen, Maria

AU - Schwab, Ursula

AU - Seppänen-Laakso, Tuulikki

AU - Mattila, Ismo

AU - Juntunen, Katri

AU - Mykkänen, Hannu

AU - Poutanen, Kaisa

AU - Gylling, Helena

AU - Orešič, Matej

PY - 2010

Y1 - 2010

N2 - The evidence of the beneficial health effects of dietary fiber and whole grain consumption is strong, but the underlying mechanisms are not completely understood. Here, we investigate how the consumption of high-fiber rye bread (RB) or white-wheat bread (WB) modifies the plasma metabolomic profiles in postmenopausal women. The study was a randomized crossover trial consisting of 8-wk intervention periods and an 8-wk washout period. The study included 39 postmenopausal women with elevated serum total cholesterol (5.0–8.5 mmol/L) and BMI 20–33 kg/m2. During the intervention periods, the study breads contributed to least 20% of total energy intake. Two analytical platforms for metabolomics were applied. Lipidomic analysis was performed using ultra performance liquid chromatography coupled to electrospray ionization MS and the other metabolites, including sterols, organic acids, and alcohols, were analyzed by 2-dimensional GC coupled to time-of-flight MS. Altogether, 540 metabolites were profiled. Ribitol (P < 0.001), ribonic acid (P < 0.001), and indoleacetic acid (P < 0.001) increased during the RB consumption period. Ribonic acid correlated positively with tryptophan (r = 0.40; P = 0.003), which is a precursor for the biosynthesis of hunger-depressing serotonin. There were no changes in plasma lipidomic profiles during the RB or WB intervention periods. The results suggest that 8-wk consumption of high-fiber rye bread increases metabolites that might mediate positive effects of rye bread on satiety and weight maintenance.

AB - The evidence of the beneficial health effects of dietary fiber and whole grain consumption is strong, but the underlying mechanisms are not completely understood. Here, we investigate how the consumption of high-fiber rye bread (RB) or white-wheat bread (WB) modifies the plasma metabolomic profiles in postmenopausal women. The study was a randomized crossover trial consisting of 8-wk intervention periods and an 8-wk washout period. The study included 39 postmenopausal women with elevated serum total cholesterol (5.0–8.5 mmol/L) and BMI 20–33 kg/m2. During the intervention periods, the study breads contributed to least 20% of total energy intake. Two analytical platforms for metabolomics were applied. Lipidomic analysis was performed using ultra performance liquid chromatography coupled to electrospray ionization MS and the other metabolites, including sterols, organic acids, and alcohols, were analyzed by 2-dimensional GC coupled to time-of-flight MS. Altogether, 540 metabolites were profiled. Ribitol (P < 0.001), ribonic acid (P < 0.001), and indoleacetic acid (P < 0.001) increased during the RB consumption period. Ribonic acid correlated positively with tryptophan (r = 0.40; P = 0.003), which is a precursor for the biosynthesis of hunger-depressing serotonin. There were no changes in plasma lipidomic profiles during the RB or WB intervention periods. The results suggest that 8-wk consumption of high-fiber rye bread increases metabolites that might mediate positive effects of rye bread on satiety and weight maintenance.

U2 - 10.3945/jn.110.131656

DO - 10.3945/jn.110.131656

M3 - Article

VL - 141

SP - 31

EP - 36

JO - Journal of Nutrition

JF - Journal of Nutrition

SN - 0022-3166

IS - 1

ER -