Metabolomic approaches to phenotype characterization and applications to complex diseases

Matej Orešič (Corresponding Author), Antonio Vidal-Puig, Virve Hänninen

Research output: Contribution to journalReview Articlepeer-review

86 Citations (Scopus)


Metabolites are the key regulators of systems homeostasis. As such, concentration changes of specific groups of metabolites may reflect systemic responses to environmental, therapeutic or genetic interventions. Thus, the study of metabolites is a powerful tool for the characterization of complex phenotypes as well as for the development of biomarkers for specific physiological responses. Therefore, metabolomics is a valuable platform for studies of complex diseases and the development of new therapies, both in nonclinical disease model characterization and clinical settings.
Original languageEnglish
Pages (from-to)575-585
JournalExpert Review of Molecular Diagnostics
Issue number4
Publication statusPublished - 2006
MoE publication typeA2 Review article in a scientific journal


  • biomarker
  • critical path research
  • metabolomics
  • pharmacology
  • quantitative disease model
  • systems biology
  • toxicology
  • translational path research


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