Metabolomic approaches to phenotype characterization and applications to complex diseases

Matej Oresic, Antonio Vidal-Puig, Virve Hänninen

Research output: Contribution to journalReview ArticleScientificpeer-review

81 Citations (Scopus)

Abstract

Metabolites are the key regulators of systems homeostasis. As such, concentration changes of specific groups of metabolites may reflect systemic responses to environmental, therapeutic or genetic interventions. Thus, the study of metabolites is a powerful tool for the characterization of complex phenotypes as well as for the development of biomarkers for specific physiological responses. Therefore, metabolomics is a valuable platform for studies of complex diseases and the development of new therapies, both in nonclinical disease model characterization and clinical settings.
Original languageEnglish
Pages (from-to)575-585
Number of pages11
JournalExpert Review of Molecular Diagnostics
Volume6
Issue number4
DOIs
Publication statusPublished - 2006
MoE publication typeA2 Review article in a scientific journal

Fingerprint

Metabolomics
Phenotype
Genetic Engineering
Homeostasis
Biomarkers
Therapeutics

Keywords

  • biomarker
  • critical path research
  • metabolomics
  • pharmacology
  • quantitative disease model
  • systems biology
  • toxicology
  • translational path research

Cite this

Oresic, Matej ; Vidal-Puig, Antonio ; Hänninen, Virve. / Metabolomic approaches to phenotype characterization and applications to complex diseases. In: Expert Review of Molecular Diagnostics. 2006 ; Vol. 6, No. 4. pp. 575-585.
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Metabolomic approaches to phenotype characterization and applications to complex diseases. / Oresic, Matej; Vidal-Puig, Antonio; Hänninen, Virve.

In: Expert Review of Molecular Diagnostics, Vol. 6, No. 4, 2006, p. 575-585.

Research output: Contribution to journalReview ArticleScientificpeer-review

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AU - Vidal-Puig, Antonio

AU - Hänninen, Virve

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KW - critical path research

KW - metabolomics

KW - pharmacology

KW - quantitative disease model

KW - systems biology

KW - toxicology

KW - translational path research

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JF - Expert Review of Molecular Diagnostics

SN - 1473-7159

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