Metabolomics, a novel tool for studies of nutrition, metabolism and lipid dysfunction

Matej Orešič (Corresponding Author)

Research output: Contribution to journalReview ArticleScientificpeer-review

99 Citations (Scopus)

Abstract

Aims; In this review metabolomics is introduced in historic perspective, with key platforms and bioinformatics methodologies described. An overview is provided covering recent applications of metabolomics and lipidomics in the context of human physiology, lipid metabolism and nutrition.

Data synthesis: Global coverage of human metabolome requires application of multiple analytical platforms. The choice of a particular targeted or non-targeted analytical strategy depends on the hypothesis tested, state-of-the-art in the field, as well as on sample availability. Human metabolome has been shown to be sensitive to age, gut microbial composition, and lifestyle. Several studies have shown that, given the appropriate experimental design, subtle effects of interventions such as change of diet or weight loss can be detected by metabolomics and studied in the context of human physiology and health status.

Conclusion: Metabolome provides a sensitive intermediate phenotype linking the genotype, gut microbial composition and personal health status. Innovative experimental designs combined with novel computational tools for handling metabolomics data offer new opportunities for early disease detection as well as for characterization of dietary and therapeutic interventions in the context of human physiology.
Original languageEnglish
Pages (from-to)816-824
JournalNutrition, Metabolism and Cardiovascular Diseases
Volume19
Issue number11
DOIs
Publication statusPublished - 2009
MoE publication typeA2 Review article in a scientific journal

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Metabolomics
Lipid Metabolism
Metabolome
Health Status
Research Design
Reducing Diet
Computational Biology
Life Style
Early Diagnosis
Genotype
Phenotype

Keywords

  • Lipid metabolism
  • lipidomics
  • nutrition
  • mass spectrometry
  • metabolomics
  • systems biology

Cite this

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title = "Metabolomics, a novel tool for studies of nutrition, metabolism and lipid dysfunction",
abstract = "Aims; In this review metabolomics is introduced in historic perspective, with key platforms and bioinformatics methodologies described. An overview is provided covering recent applications of metabolomics and lipidomics in the context of human physiology, lipid metabolism and nutrition.Data synthesis: Global coverage of human metabolome requires application of multiple analytical platforms. The choice of a particular targeted or non-targeted analytical strategy depends on the hypothesis tested, state-of-the-art in the field, as well as on sample availability. Human metabolome has been shown to be sensitive to age, gut microbial composition, and lifestyle. Several studies have shown that, given the appropriate experimental design, subtle effects of interventions such as change of diet or weight loss can be detected by metabolomics and studied in the context of human physiology and health status.Conclusion: Metabolome provides a sensitive intermediate phenotype linking the genotype, gut microbial composition and personal health status. Innovative experimental designs combined with novel computational tools for handling metabolomics data offer new opportunities for early disease detection as well as for characterization of dietary and therapeutic interventions in the context of human physiology.",
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language = "English",
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Metabolomics, a novel tool for studies of nutrition, metabolism and lipid dysfunction. / Orešič, Matej (Corresponding Author).

In: Nutrition, Metabolism and Cardiovascular Diseases, Vol. 19, No. 11, 2009, p. 816-824.

Research output: Contribution to journalReview ArticleScientificpeer-review

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T1 - Metabolomics, a novel tool for studies of nutrition, metabolism and lipid dysfunction

AU - Orešič, Matej

PY - 2009

Y1 - 2009

N2 - Aims; In this review metabolomics is introduced in historic perspective, with key platforms and bioinformatics methodologies described. An overview is provided covering recent applications of metabolomics and lipidomics in the context of human physiology, lipid metabolism and nutrition.Data synthesis: Global coverage of human metabolome requires application of multiple analytical platforms. The choice of a particular targeted or non-targeted analytical strategy depends on the hypothesis tested, state-of-the-art in the field, as well as on sample availability. Human metabolome has been shown to be sensitive to age, gut microbial composition, and lifestyle. Several studies have shown that, given the appropriate experimental design, subtle effects of interventions such as change of diet or weight loss can be detected by metabolomics and studied in the context of human physiology and health status.Conclusion: Metabolome provides a sensitive intermediate phenotype linking the genotype, gut microbial composition and personal health status. Innovative experimental designs combined with novel computational tools for handling metabolomics data offer new opportunities for early disease detection as well as for characterization of dietary and therapeutic interventions in the context of human physiology.

AB - Aims; In this review metabolomics is introduced in historic perspective, with key platforms and bioinformatics methodologies described. An overview is provided covering recent applications of metabolomics and lipidomics in the context of human physiology, lipid metabolism and nutrition.Data synthesis: Global coverage of human metabolome requires application of multiple analytical platforms. The choice of a particular targeted or non-targeted analytical strategy depends on the hypothesis tested, state-of-the-art in the field, as well as on sample availability. Human metabolome has been shown to be sensitive to age, gut microbial composition, and lifestyle. Several studies have shown that, given the appropriate experimental design, subtle effects of interventions such as change of diet or weight loss can be detected by metabolomics and studied in the context of human physiology and health status.Conclusion: Metabolome provides a sensitive intermediate phenotype linking the genotype, gut microbial composition and personal health status. Innovative experimental designs combined with novel computational tools for handling metabolomics data offer new opportunities for early disease detection as well as for characterization of dietary and therapeutic interventions in the context of human physiology.

KW - Lipid metabolism

KW - lipidomics

KW - nutrition

KW - mass spectrometry

KW - metabolomics

KW - systems biology

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JO - Nutrition, Metabolism and Cardiovascular Diseases

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SN - 0939-4753

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