Micelle Formation of Coenzyme Q10 with Dipotassium Glycyrrhizate Using Inclusion Complex of Coenzyme Q10 with γ-Cyclodextrin

Yukiko Uekaji; Mayu Onishi; Daisuke Nakata; Keiji Terao; Arja Paananen; Riitta Partanen; Hidefumi Yoshii

doi:10.1021/jp5065165

Micelle Formation of Coenzyme Q₁₀ with Dipotassium Glycyrrhizate Using Inclusion Complex of Coenzyme Q₁₀ with γ-Cyclodextrin

Yukiko Uekaji, Mayu Onishi, Daisuke Nakata, Keiji Terao, Arja Paananen, Riitta Partanen, Hidefumi Yoshii (Corresponding Author)

Research output: Contribution to journal › Article › Scientific › peer-review

11 Citations (Scopus)

Abstract

Micelles can be formed from coenzyme Q10 (CoQ10) and dipotassium glycyrrhizate (GZK2) by using an inclusion complex of CoQ10 with γ-cyclodextrin (γ-CD). The mechanism of micelle formation was kinetically investigated. Adding GZK2 to a supersaturated solution of the CoQ10/γ-CD inclusion complex led to a linear increase in the solubility of CoQ10 due to the formation of micelles of CoQ10 when the molar ratio of GZK2/γ-CD increased to ∼1.6, after which the concentration remained constant. The equilibrium constant K for micelle formation was 0.68 (−) and the ratio of GZK2 to CoQ10 was 1. These results suggest that the formation of CoQ10 micelles with GZK2 might proceed via the displacement of CoQ10 by GZK2 in the γ-CD cavity followed by the formation of CoQ10 micelles.

Original language	English
Pages (from-to)	11480-11486
Journal	The Journal of Physical Chemistry B
Volume	118
Issue number	39
DOIs	https://doi.org/10.1021/jp5065165
Publication status	Published - 2014
MoE publication type	A1 Journal article-refereed

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10.1021/jp5065165

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@article{7243a5cae66848a4acc4ac34900629cb,

title = "Micelle Formation of Coenzyme Q10 with Dipotassium Glycyrrhizate Using Inclusion Complex of Coenzyme Q10 with γ-Cyclodextrin",

abstract = "Micelles can be formed from coenzyme Q10 (CoQ10) and dipotassium glycyrrhizate (GZK2) by using an inclusion complex of CoQ10 with γ-cyclodextrin (γ-CD). The mechanism of micelle formation was kinetically investigated. Adding GZK2 to a supersaturated solution of the CoQ10/γ-CD inclusion complex led to a linear increase in the solubility of CoQ10 due to the formation of micelles of CoQ10 when the molar ratio of GZK2/γ-CD increased to ∼1.6, after which the concentration remained constant. The equilibrium constant K for micelle formation was 0.68 (−) and the ratio of GZK2 to CoQ10 was 1. These results suggest that the formation of CoQ10 micelles with GZK2 might proceed via the displacement of CoQ10 by GZK2 in the γ-CD cavity followed by the formation of CoQ10 micelles.",

author = "Yukiko Uekaji and Mayu Onishi and Daisuke Nakata and Keiji Terao and Arja Paananen and Riitta Partanen and Hidefumi Yoshii",

year = "2014",

doi = "10.1021/jp5065165",

language = "English",

volume = "118",

pages = "11480--11486",

journal = "The Journal of Physical Chemistry B",

issn = "1520-6106",

publisher = "American Chemical Society ACS",

number = "39",

}

Micelle Formation of Coenzyme Q₁₀ with Dipotassium Glycyrrhizate Using Inclusion Complex of Coenzyme Q₁₀ with γ-Cyclodextrin. / Uekaji, Yukiko; Onishi, Mayu; Nakata, Daisuke; Terao, Keiji; Paananen, Arja; Partanen, Riitta; Yoshii, Hidefumi (Corresponding Author).

In: The Journal of Physical Chemistry B, Vol. 118, No. 39, 2014, p. 11480-11486.

Research output: Contribution to journal › Article › Scientific › peer-review

TY - JOUR

T1 - Micelle Formation of Coenzyme Q10 with Dipotassium Glycyrrhizate Using Inclusion Complex of Coenzyme Q10 with γ-Cyclodextrin

AU - Uekaji, Yukiko

AU - Onishi, Mayu

AU - Nakata, Daisuke

AU - Terao, Keiji

AU - Paananen, Arja

AU - Partanen, Riitta

AU - Yoshii, Hidefumi

PY - 2014

Y1 - 2014

N2 - Micelles can be formed from coenzyme Q10 (CoQ10) and dipotassium glycyrrhizate (GZK2) by using an inclusion complex of CoQ10 with γ-cyclodextrin (γ-CD). The mechanism of micelle formation was kinetically investigated. Adding GZK2 to a supersaturated solution of the CoQ10/γ-CD inclusion complex led to a linear increase in the solubility of CoQ10 due to the formation of micelles of CoQ10 when the molar ratio of GZK2/γ-CD increased to ∼1.6, after which the concentration remained constant. The equilibrium constant K for micelle formation was 0.68 (−) and the ratio of GZK2 to CoQ10 was 1. These results suggest that the formation of CoQ10 micelles with GZK2 might proceed via the displacement of CoQ10 by GZK2 in the γ-CD cavity followed by the formation of CoQ10 micelles.

AB - Micelles can be formed from coenzyme Q10 (CoQ10) and dipotassium glycyrrhizate (GZK2) by using an inclusion complex of CoQ10 with γ-cyclodextrin (γ-CD). The mechanism of micelle formation was kinetically investigated. Adding GZK2 to a supersaturated solution of the CoQ10/γ-CD inclusion complex led to a linear increase in the solubility of CoQ10 due to the formation of micelles of CoQ10 when the molar ratio of GZK2/γ-CD increased to ∼1.6, after which the concentration remained constant. The equilibrium constant K for micelle formation was 0.68 (−) and the ratio of GZK2 to CoQ10 was 1. These results suggest that the formation of CoQ10 micelles with GZK2 might proceed via the displacement of CoQ10 by GZK2 in the γ-CD cavity followed by the formation of CoQ10 micelles.

U2 - 10.1021/jp5065165

DO - 10.1021/jp5065165

M3 - Article

VL - 118

SP - 11480

EP - 11486

JO - The Journal of Physical Chemistry B

JF - The Journal of Physical Chemistry B

SN - 1520-6106

IS - 39

ER -

Micelle Formation of Coenzyme Q10 with Dipotassium Glycyrrhizate Using Inclusion Complex of Coenzyme Q10 with γ-Cyclodextrin

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Micelle Formation of Coenzyme Q₁₀ with Dipotassium Glycyrrhizate Using Inclusion Complex of Coenzyme Q₁₀ with γ-Cyclodextrin