Abstract
Microfluidic technology has created new opportunities for developing innovative tools for biological applications. Given the significance of extracellular vesicles (EVs), extensive research has focused on developing microfluidic techniques for EV isolation. This research protocol presents electro-viscoelastic microfluidics as a novel approach for manipulating EVs. The system leverages the viscoelasticity of the suspending medium along with an externally applied electric field to alter EV motion within a microchannel. These findings suggest that our electro-viscoelastic microfluidic system has the potential for further development to be used for EV isolation.
| Original language | English |
|---|---|
| Pages (from-to) | 331-339 |
| Number of pages | 9 |
| Journal | FEBS Open Bio |
| Volume | 16 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Feb 2026 |
| MoE publication type | A1 Journal article-refereed |
Funding
This research was funded by the BioEVEngine project under the Kvantum Institute at the University of Oulu, Finland, as well as by the University of Oulu and the Research Council of Finland through the Profi 5 program (decision no.: 326291). C.E. also acknowledges receiving Proof of Concept (PoC) funding from the University of Oulu Innovation Centre.
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 9 Industry, Innovation, and Infrastructure
Keywords
- electrokinetics
- extracellular vesicles
- microfabrication
- microfluidics
- viscoelasticity
- Viscosity
- Microfluidic Analytical Techniques/methods
- Humans
- Microfluidics/methods
- Elasticity
- Extracellular Vesicles/metabolism
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