MicroRNA expression profiling and functional screening in bone metastatic breast cancer cells

Sirkku Pollari; Kirsi Hellström; Saija Haapa-Paananen; Suvi-Katri Leivonen; Pekka Kohonen; Niko Sahlberg; Merja Perälä; Sanna-Maria Käkönen; Matthias Nees; Olli Kallioniemi

doi:10.1016/j.ctrv.2008.03.068

MicroRNA expression profiling and functional screening in bone metastatic breast cancer cells

Sirkku Pollari, Kirsi Hellström, Saija Haapa-Paananen, Suvi-Katri Leivonen, Pekka Kohonen, Niko Sahlberg, Merja Perälä, Sanna-Maria Käkönen, Matthias Nees, Olli Kallioniemi

VTT Technical Research Centre of Finland

Research output: Contribution to journal › Other journal contribution › Scientific

Abstract

MicroRNAs (miRNAs) are noncoding single-stranded RNAs that post-transcriptionally suppress specific sets of genes. There is an increasing amount of evidence for under- and over-expression of several miRNAs in cancer as compared to the normal tissue, and miRNAs are likely to have important roles in the development of cancer metastasis as well. We have used genome-wide miRNA expression profiling and functional cell-based screening of miRNAs and miRNA inhibitors to identify differences between a highly and weakly bone metastatic variants of the breast cancer cell line MDA-MB-231.

Original language	English
Article number	P26
Pages (from-to)	22
Journal	Cancer Treatment Reviews
Volume	34
Issue number	Supplement 1
DOIs	https://doi.org/10.1016/j.ctrv.2008.03.068
Publication status	Published - 2008
MoE publication type	B1 Article in a scientific magazine
Event	VII Cancer Induced Bone Disease Meeting - Edingburgh, United Kingdom Duration: 29 Jun 2008 → 2 Jul 2008

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10.1016/j.ctrv.2008.03.068

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@article{4a630c524faa4aa98cc5549e1069856a,

title = "MicroRNA expression profiling and functional screening in bone metastatic breast cancer cells",

abstract = "MicroRNAs (miRNAs) are noncoding single-stranded RNAs that post-transcriptionally suppress specific sets of genes. There is an increasing amount of evidence for under- and over-expression of several miRNAs in cancer as compared to the normal tissue, and miRNAs are likely to have important roles in the development of cancer metastasis as well. We have used genome-wide miRNA expression profiling and functional cell-based screening of miRNAs and miRNA inhibitors to identify differences between a highly and weakly bone metastatic variants of the breast cancer cell line MDA-MB-231.",

author = "Sirkku Pollari and Kirsi Hellstr{\"o}m and Saija Haapa-Paananen and Suvi-Katri Leivonen and Pekka Kohonen and Niko Sahlberg and Merja Per{\"a}l{\"a} and Sanna-Maria K{\"a}k{\"o}nen and Matthias Nees and Olli Kallioniemi",

note = "Poster presentation; VII Cancer Induced Bone Disease Meeting ; Conference date: 29-06-2008 Through 02-07-2008",

year = "2008",

doi = "10.1016/j.ctrv.2008.03.068",

language = "English",

volume = "34",

pages = "22",

journal = "Cancer Treatment Reviews",

issn = "0305-7372",

publisher = "Elsevier",

number = "Supplement 1",

}

TY - JOUR

T1 - MicroRNA expression profiling and functional screening in bone metastatic breast cancer cells

AU - Pollari, Sirkku

AU - Hellström, Kirsi

AU - Haapa-Paananen, Saija

AU - Leivonen, Suvi-Katri

AU - Kohonen, Pekka

AU - Sahlberg, Niko

AU - Perälä, Merja

AU - Käkönen, Sanna-Maria

AU - Nees, Matthias

AU - Kallioniemi, Olli

N1 - Poster presentation

PY - 2008

Y1 - 2008

N2 - MicroRNAs (miRNAs) are noncoding single-stranded RNAs that post-transcriptionally suppress specific sets of genes. There is an increasing amount of evidence for under- and over-expression of several miRNAs in cancer as compared to the normal tissue, and miRNAs are likely to have important roles in the development of cancer metastasis as well. We have used genome-wide miRNA expression profiling and functional cell-based screening of miRNAs and miRNA inhibitors to identify differences between a highly and weakly bone metastatic variants of the breast cancer cell line MDA-MB-231.

AB - MicroRNAs (miRNAs) are noncoding single-stranded RNAs that post-transcriptionally suppress specific sets of genes. There is an increasing amount of evidence for under- and over-expression of several miRNAs in cancer as compared to the normal tissue, and miRNAs are likely to have important roles in the development of cancer metastasis as well. We have used genome-wide miRNA expression profiling and functional cell-based screening of miRNAs and miRNA inhibitors to identify differences between a highly and weakly bone metastatic variants of the breast cancer cell line MDA-MB-231.

U2 - 10.1016/j.ctrv.2008.03.068

DO - 10.1016/j.ctrv.2008.03.068

M3 - Other journal contribution

SN - 0305-7372

VL - 34

SP - 22

JO - Cancer Treatment Reviews

JF - Cancer Treatment Reviews

IS - Supplement 1

M1 - P26

T2 - VII Cancer Induced Bone Disease Meeting

Y2 - 29 June 2008 through 2 July 2008

ER -

MicroRNA expression profiling and functional screening in bone metastatic breast cancer cells

Abstract

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