MicroRNAs in Breast Cancer

Suvi-Katri Leivonen

Research output: Chapter in Book/Report/Conference proceedingChapter or book articleScientificpeer-review

Abstract

Breast cancer is a complex, phenotypically diverse genetic disease, which involves changes in gene expression and structure. Despite advances in the detection and therapy of breast cancer, it is the leading cause of cancer deaths among women worldwide. Therefore, novel diagnostic and prognostic indicators, as well as potential therapeutic targets are needed. Recently, several studies have shown an involvement for the microRNAs (miRNAs) in breast cancer. MiRNA expression profiling studies have identified sets of miRNAs which are deregulated in breast cancer, and which can separate tumor from normal tissue. Functional studies have uncovered the role of miRNAs in breast cancer as both tumor suppressors and oncogenes. Furthermore, miRNAs have been suggested to play a critical role in regulating breast cancer metastasis. The purpose of this chapter is to present an overview of our current understanding of miRNAs in breast cancer with specific emphasis on miRNAs as potential therapeutic targets.
Original languageEnglish
Title of host publicationMicroRNAs in Cancer Translational Research. Cho, W.C.S. (ed.)
EditorsWilliam C.S. Cho
PublisherSpringer
Chapter3
Pages91-106
ISBN (Electronic)978-94-007-0298-1
ISBN (Print)978-94-007-0297-4
DOIs
Publication statusPublished - 2011
MoE publication typeA3 Part of a book or another research book

Fingerprint

MicroRNAs
Breast Neoplasms
Neoplasms
Inborn Genetic Diseases
Oncogenes
Cause of Death
Therapeutics
Neoplasm Metastasis
Gene Expression

Keywords

  • breast cancer
  • cancer

Cite this

Leivonen, S-K. (2011). MicroRNAs in Breast Cancer. In W. C. S. Cho (Ed.), MicroRNAs in Cancer Translational Research. Cho, W.C.S. (ed.) (pp. 91-106). Springer. https://doi.org/10.1007/978-94-007-0298-1_3
Leivonen, Suvi-Katri. / MicroRNAs in Breast Cancer. MicroRNAs in Cancer Translational Research. Cho, W.C.S. (ed.). editor / William C.S. Cho. Springer, 2011. pp. 91-106
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Leivonen, S-K 2011, MicroRNAs in Breast Cancer. in WCS Cho (ed.), MicroRNAs in Cancer Translational Research. Cho, W.C.S. (ed.). Springer, pp. 91-106. https://doi.org/10.1007/978-94-007-0298-1_3

MicroRNAs in Breast Cancer. / Leivonen, Suvi-Katri.

MicroRNAs in Cancer Translational Research. Cho, W.C.S. (ed.). ed. / William C.S. Cho. Springer, 2011. p. 91-106.

Research output: Chapter in Book/Report/Conference proceedingChapter or book articleScientificpeer-review

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AB - Breast cancer is a complex, phenotypically diverse genetic disease, which involves changes in gene expression and structure. Despite advances in the detection and therapy of breast cancer, it is the leading cause of cancer deaths among women worldwide. Therefore, novel diagnostic and prognostic indicators, as well as potential therapeutic targets are needed. Recently, several studies have shown an involvement for the microRNAs (miRNAs) in breast cancer. MiRNA expression profiling studies have identified sets of miRNAs which are deregulated in breast cancer, and which can separate tumor from normal tissue. Functional studies have uncovered the role of miRNAs in breast cancer as both tumor suppressors and oncogenes. Furthermore, miRNAs have been suggested to play a critical role in regulating breast cancer metastasis. The purpose of this chapter is to present an overview of our current understanding of miRNAs in breast cancer with specific emphasis on miRNAs as potential therapeutic targets.

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Leivonen S-K. MicroRNAs in Breast Cancer. In Cho WCS, editor, MicroRNAs in Cancer Translational Research. Cho, W.C.S. (ed.). Springer. 2011. p. 91-106 https://doi.org/10.1007/978-94-007-0298-1_3