Mimicking Neurotransmitter Release and Long‐Term Plasticity by Oxygen Vacancy Migration in a Tunnel Junction Memristor

Hongwei Tan (Corresponding Author), Sayani Majumdar, Qihang Qin, Jouko Lahtinen, Sebastiaan van Dijken (Corresponding Author)

    Research output: Contribution to journalArticleScientificpeer-review

    Abstract

    Activated by action potentials and Ca2+ ion migration, neurotransmitters in biological synapses are released from vesicles at the presynaptic membrane to the cleft and bonded to receptors on the postsynaptic membrane. The bonded neurotransmitters modify the electrochemical properties of the postsynaptic membrane and, thereby, the synaptic plasticity, which forms the basis for learning, memory, emotion, cognition, and consciousness. Here, the oxygen vacancy transport in Au/SrTiO3 (STO)/La0.67Sr0.33MnO3 (LSMO) tunnel junctions is exploited to mimic neurotransmission processes in an artificial ionic electronic device. Using voltage pulses of varying number, amplitude, and polarity, it is demonstrated that reversible oxygen vacancy migration across the STO/LSMO interface provides stable multilevel resistance switching for octal memory devices and resembles the quantal, stochastic, and excitatory or inhibitory nature of neurotransmitter release dynamics. Moreover, fundamental synaptic behaviors including long‐term potentiation/depression and various types of spike‐timing‐dependent plasticity characteristics are emulated, opening a promising biorealistic approach to the design of neuromorphic devices.
    Original languageEnglish
    Article number1900036
    Pages (from-to)1
    Number of pages8
    JournalAdvanced Intelligent Systems
    Volume1
    Issue number2
    DOIs
    Publication statusPublished - 26 Jun 2019
    MoE publication typeA1 Journal article-refereed

    Fingerprint

    Neurotransmitter Agents
    Oxygen
    Membranes
    Equipment Design
    Equipment and Supplies
    Neuronal Plasticity
    Consciousness
    Synaptic Transmission
    Synapses
    Cognition
    Action Potentials
    Emotions
    Learning
    Ions
    Depression
    strontium titanium oxide

    Keywords

    • neuromorphic computing
    • oxide tunnel junction

    Cite this

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    title = "Mimicking Neurotransmitter Release and Long‐Term Plasticity by Oxygen Vacancy Migration in a Tunnel Junction Memristor",
    abstract = "Activated by action potentials and Ca2+ ion migration, neurotransmitters in biological synapses are released from vesicles at the presynaptic membrane to the cleft and bonded to receptors on the postsynaptic membrane. The bonded neurotransmitters modify the electrochemical properties of the postsynaptic membrane and, thereby, the synaptic plasticity, which forms the basis for learning, memory, emotion, cognition, and consciousness. Here, the oxygen vacancy transport in Au/SrTiO3 (STO)/La0.67Sr0.33MnO3 (LSMO) tunnel junctions is exploited to mimic neurotransmission processes in an artificial ionic electronic device. Using voltage pulses of varying number, amplitude, and polarity, it is demonstrated that reversible oxygen vacancy migration across the STO/LSMO interface provides stable multilevel resistance switching for octal memory devices and resembles the quantal, stochastic, and excitatory or inhibitory nature of neurotransmitter release dynamics. Moreover, fundamental synaptic behaviors including long‐term potentiation/depression and various types of spike‐timing‐dependent plasticity characteristics are emulated, opening a promising biorealistic approach to the design of neuromorphic devices.",
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    year = "2019",
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    doi = "10.1002/aisy.201900036",
    language = "English",
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    Mimicking Neurotransmitter Release and Long‐Term Plasticity by Oxygen Vacancy Migration in a Tunnel Junction Memristor. / Tan, Hongwei (Corresponding Author); Majumdar, Sayani; Qin, Qihang; Lahtinen, Jouko; van Dijken, Sebastiaan (Corresponding Author).

    In: Advanced Intelligent Systems, Vol. 1, No. 2, 1900036, 26.06.2019, p. 1.

    Research output: Contribution to journalArticleScientificpeer-review

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    AU - Tan, Hongwei

    AU - Majumdar, Sayani

    AU - Qin, Qihang

    AU - Lahtinen, Jouko

    AU - van Dijken, Sebastiaan

    PY - 2019/6/26

    Y1 - 2019/6/26

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    AB - Activated by action potentials and Ca2+ ion migration, neurotransmitters in biological synapses are released from vesicles at the presynaptic membrane to the cleft and bonded to receptors on the postsynaptic membrane. The bonded neurotransmitters modify the electrochemical properties of the postsynaptic membrane and, thereby, the synaptic plasticity, which forms the basis for learning, memory, emotion, cognition, and consciousness. Here, the oxygen vacancy transport in Au/SrTiO3 (STO)/La0.67Sr0.33MnO3 (LSMO) tunnel junctions is exploited to mimic neurotransmission processes in an artificial ionic electronic device. Using voltage pulses of varying number, amplitude, and polarity, it is demonstrated that reversible oxygen vacancy migration across the STO/LSMO interface provides stable multilevel resistance switching for octal memory devices and resembles the quantal, stochastic, and excitatory or inhibitory nature of neurotransmitter release dynamics. Moreover, fundamental synaptic behaviors including long‐term potentiation/depression and various types of spike‐timing‐dependent plasticity characteristics are emulated, opening a promising biorealistic approach to the design of neuromorphic devices.

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