Mimicking Neurotransmitter Release and Long‐Term Plasticity by Oxygen Vacancy Migration in a Tunnel Junction Memristor

Hongwei Tan (Corresponding Author), Sayani Majumdar, Qihang Qin, Jouko Lahtinen, Sebastiaan van Dijken (Corresponding Author)

Research output: Contribution to journalArticleScientificpeer-review

Abstract

Activated by action potentials and Ca2+ ion migration, neurotransmitters in biological synapses are released from vesicles at the presynaptic membrane to the cleft and bonded to receptors on the postsynaptic membrane. The bonded neurotransmitters modify the electrochemical properties of the postsynaptic membrane and, thereby, the synaptic plasticity, which forms the basis for learning, memory, emotion, cognition, and consciousness. Here, the oxygen vacancy transport in Au/SrTiO3 (STO)/La0.67Sr0.33MnO3 (LSMO) tunnel junctions is exploited to mimic neurotransmission processes in an artificial ionic electronic device. Using voltage pulses of varying number, amplitude, and polarity, it is demonstrated that reversible oxygen vacancy migration across the STO/LSMO interface provides stable multilevel resistance switching for octal memory devices and resembles the quantal, stochastic, and excitatory or inhibitory nature of neurotransmitter release dynamics. Moreover, fundamental synaptic behaviors including long‐term potentiation/depression and various types of spike‐timing‐dependent plasticity characteristics are emulated, opening a promising biorealistic approach to the design of neuromorphic devices.
Original languageEnglish
Article number1900036
Pages (from-to)1
Number of pages8
JournalAdvanced Intelligent Systems
Volume1
Issue number2
DOIs
Publication statusPublished - 26 Jun 2019
MoE publication typeA1 Journal article-refereed

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Neurotransmitter Agents
Oxygen
Membranes
Equipment Design
Equipment and Supplies
Neuronal Plasticity
Consciousness
Synaptic Transmission
Synapses
Cognition
Action Potentials
Emotions
Learning
Ions
Depression
strontium titanium oxide

Keywords

  • neuromorphic computing
  • oxide tunnel junction

Cite this

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title = "Mimicking Neurotransmitter Release and Long‐Term Plasticity by Oxygen Vacancy Migration in a Tunnel Junction Memristor",
abstract = "Activated by action potentials and Ca2+ ion migration, neurotransmitters in biological synapses are released from vesicles at the presynaptic membrane to the cleft and bonded to receptors on the postsynaptic membrane. The bonded neurotransmitters modify the electrochemical properties of the postsynaptic membrane and, thereby, the synaptic plasticity, which forms the basis for learning, memory, emotion, cognition, and consciousness. Here, the oxygen vacancy transport in Au/SrTiO3 (STO)/La0.67Sr0.33MnO3 (LSMO) tunnel junctions is exploited to mimic neurotransmission processes in an artificial ionic electronic device. Using voltage pulses of varying number, amplitude, and polarity, it is demonstrated that reversible oxygen vacancy migration across the STO/LSMO interface provides stable multilevel resistance switching for octal memory devices and resembles the quantal, stochastic, and excitatory or inhibitory nature of neurotransmitter release dynamics. Moreover, fundamental synaptic behaviors including long‐term potentiation/depression and various types of spike‐timing‐dependent plasticity characteristics are emulated, opening a promising biorealistic approach to the design of neuromorphic devices.",
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Mimicking Neurotransmitter Release and Long‐Term Plasticity by Oxygen Vacancy Migration in a Tunnel Junction Memristor. / Tan, Hongwei (Corresponding Author); Majumdar, Sayani; Qin, Qihang; Lahtinen, Jouko; van Dijken, Sebastiaan (Corresponding Author).

In: Advanced Intelligent Systems, Vol. 1, No. 2, 1900036, 26.06.2019, p. 1.

Research output: Contribution to journalArticleScientificpeer-review

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AU - Majumdar, Sayani

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AU - Lahtinen, Jouko

AU - van Dijken, Sebastiaan

PY - 2019/6/26

Y1 - 2019/6/26

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