Mind the gap-deficits in our knowledge of aspects impacting the bioavailability of phytochemicals and their metabolites-a position paper focusing on carotenoids and polyphenols

Torsten Bohn (Corresponding Author), Gordon J. Mcdougall, Amparo Alegría, Marie Alminger, Eva Arrigoni, Anna Marja Aura, Catarina Brito, Antonio Cilla, Sedef N. El, Sibel Karakaya, Marie C. Martínez-Cuesta, Claudia N. Santos

    Research output: Contribution to journalReview ArticleScientificpeer-review

    92 Citations (Scopus)

    Abstract

    Various secondary plant metabolites or phytochemicals, including polyphenols and carotenoids, have been associated with a variety of health benefits, such as reduced incidence of type 2 diabetes, cardiovascular diseases, and several types of cancer, most likely due to their involvement in ameliorating inflammation and oxidative stress. However, discrepancies exist between their putative effects when comparing observational and intervention studies, especially when using pure compounds. These discrepancies may in part be explained by differences in intake levels and their bioavailability. Prior to exerting their bioactivity, these compounds must be made bioavailable, and considerable differences may arise due to their matrix release, changes during digestion, uptake, metabolism, and biodistribution, even before considering dose- and host-related factors. Though many insights have been gained on factors affecting secondary plant metabolite bioavailability, many gaps still exist in our knowledge. In this position paper, we highlight several major gaps in our understanding of phytochemical bioavailability, including effects of food processing, changes during digestion, involvement of cellular transporters in influx/efflux through the gastrointestinal epithelium, changes during colonic fermentation, and their phase I and phase II metabolism following absorption.

    Original languageEnglish
    Pages (from-to)1307-1323
    Number of pages17
    JournalMolecular Nutrition and Food Research
    Volume59
    Issue number7
    DOIs
    Publication statusPublished - Jul 2015
    MoE publication typeA2 Review article in a scientific journal

    Fingerprint

    Phytochemicals
    Polyphenols
    Carotenoids
    phytopharmaceuticals
    Biological Availability
    bioavailability
    polyphenols
    carotenoids
    metabolites
    Digestion
    digestion
    Food Handling
    metabolism
    Insurance Benefits
    food processing
    noninsulin-dependent diabetes mellitus
    Type 2 Diabetes Mellitus
    cardiovascular diseases
    Fermentation
    Observational Studies

    Keywords

    • Biotransformation
    • Food processing
    • Microbiota
    • Mixed diet
    • Transporters

    Cite this

    Bohn, Torsten ; Mcdougall, Gordon J. ; Alegría, Amparo ; Alminger, Marie ; Arrigoni, Eva ; Aura, Anna Marja ; Brito, Catarina ; Cilla, Antonio ; El, Sedef N. ; Karakaya, Sibel ; Martínez-Cuesta, Marie C. ; Santos, Claudia N. / Mind the gap-deficits in our knowledge of aspects impacting the bioavailability of phytochemicals and their metabolites-a position paper focusing on carotenoids and polyphenols. In: Molecular Nutrition and Food Research. 2015 ; Vol. 59, No. 7. pp. 1307-1323.
    @article{9507d46debdf45bba677741416efb212,
    title = "Mind the gap-deficits in our knowledge of aspects impacting the bioavailability of phytochemicals and their metabolites-a position paper focusing on carotenoids and polyphenols",
    abstract = "Various secondary plant metabolites or phytochemicals, including polyphenols and carotenoids, have been associated with a variety of health benefits, such as reduced incidence of type 2 diabetes, cardiovascular diseases, and several types of cancer, most likely due to their involvement in ameliorating inflammation and oxidative stress. However, discrepancies exist between their putative effects when comparing observational and intervention studies, especially when using pure compounds. These discrepancies may in part be explained by differences in intake levels and their bioavailability. Prior to exerting their bioactivity, these compounds must be made bioavailable, and considerable differences may arise due to their matrix release, changes during digestion, uptake, metabolism, and biodistribution, even before considering dose- and host-related factors. Though many insights have been gained on factors affecting secondary plant metabolite bioavailability, many gaps still exist in our knowledge. In this position paper, we highlight several major gaps in our understanding of phytochemical bioavailability, including effects of food processing, changes during digestion, involvement of cellular transporters in influx/efflux through the gastrointestinal epithelium, changes during colonic fermentation, and their phase I and phase II metabolism following absorption.",
    keywords = "Biotransformation, Food processing, Microbiota, Mixed diet, Transporters",
    author = "Torsten Bohn and Mcdougall, {Gordon J.} and Amparo Alegr{\'i}a and Marie Alminger and Eva Arrigoni and Aura, {Anna Marja} and Catarina Brito and Antonio Cilla and El, {Sedef N.} and Sibel Karakaya and Mart{\'i}nez-Cuesta, {Marie C.} and Santos, {Claudia N.}",
    year = "2015",
    month = "7",
    doi = "10.1002/mnfr.201400745",
    language = "English",
    volume = "59",
    pages = "1307--1323",
    journal = "Molecular Nutrition and Food Research",
    issn = "1613-4125",
    publisher = "Wiley",
    number = "7",

    }

    Bohn, T, Mcdougall, GJ, Alegría, A, Alminger, M, Arrigoni, E, Aura, AM, Brito, C, Cilla, A, El, SN, Karakaya, S, Martínez-Cuesta, MC & Santos, CN 2015, 'Mind the gap-deficits in our knowledge of aspects impacting the bioavailability of phytochemicals and their metabolites-a position paper focusing on carotenoids and polyphenols', Molecular Nutrition and Food Research, vol. 59, no. 7, pp. 1307-1323. https://doi.org/10.1002/mnfr.201400745

    Mind the gap-deficits in our knowledge of aspects impacting the bioavailability of phytochemicals and their metabolites-a position paper focusing on carotenoids and polyphenols. / Bohn, Torsten (Corresponding Author); Mcdougall, Gordon J.; Alegría, Amparo; Alminger, Marie; Arrigoni, Eva; Aura, Anna Marja; Brito, Catarina; Cilla, Antonio; El, Sedef N.; Karakaya, Sibel; Martínez-Cuesta, Marie C.; Santos, Claudia N.

    In: Molecular Nutrition and Food Research, Vol. 59, No. 7, 07.2015, p. 1307-1323.

    Research output: Contribution to journalReview ArticleScientificpeer-review

    TY - JOUR

    T1 - Mind the gap-deficits in our knowledge of aspects impacting the bioavailability of phytochemicals and their metabolites-a position paper focusing on carotenoids and polyphenols

    AU - Bohn, Torsten

    AU - Mcdougall, Gordon J.

    AU - Alegría, Amparo

    AU - Alminger, Marie

    AU - Arrigoni, Eva

    AU - Aura, Anna Marja

    AU - Brito, Catarina

    AU - Cilla, Antonio

    AU - El, Sedef N.

    AU - Karakaya, Sibel

    AU - Martínez-Cuesta, Marie C.

    AU - Santos, Claudia N.

    PY - 2015/7

    Y1 - 2015/7

    N2 - Various secondary plant metabolites or phytochemicals, including polyphenols and carotenoids, have been associated with a variety of health benefits, such as reduced incidence of type 2 diabetes, cardiovascular diseases, and several types of cancer, most likely due to their involvement in ameliorating inflammation and oxidative stress. However, discrepancies exist between their putative effects when comparing observational and intervention studies, especially when using pure compounds. These discrepancies may in part be explained by differences in intake levels and their bioavailability. Prior to exerting their bioactivity, these compounds must be made bioavailable, and considerable differences may arise due to their matrix release, changes during digestion, uptake, metabolism, and biodistribution, even before considering dose- and host-related factors. Though many insights have been gained on factors affecting secondary plant metabolite bioavailability, many gaps still exist in our knowledge. In this position paper, we highlight several major gaps in our understanding of phytochemical bioavailability, including effects of food processing, changes during digestion, involvement of cellular transporters in influx/efflux through the gastrointestinal epithelium, changes during colonic fermentation, and their phase I and phase II metabolism following absorption.

    AB - Various secondary plant metabolites or phytochemicals, including polyphenols and carotenoids, have been associated with a variety of health benefits, such as reduced incidence of type 2 diabetes, cardiovascular diseases, and several types of cancer, most likely due to their involvement in ameliorating inflammation and oxidative stress. However, discrepancies exist between their putative effects when comparing observational and intervention studies, especially when using pure compounds. These discrepancies may in part be explained by differences in intake levels and their bioavailability. Prior to exerting their bioactivity, these compounds must be made bioavailable, and considerable differences may arise due to their matrix release, changes during digestion, uptake, metabolism, and biodistribution, even before considering dose- and host-related factors. Though many insights have been gained on factors affecting secondary plant metabolite bioavailability, many gaps still exist in our knowledge. In this position paper, we highlight several major gaps in our understanding of phytochemical bioavailability, including effects of food processing, changes during digestion, involvement of cellular transporters in influx/efflux through the gastrointestinal epithelium, changes during colonic fermentation, and their phase I and phase II metabolism following absorption.

    KW - Biotransformation

    KW - Food processing

    KW - Microbiota

    KW - Mixed diet

    KW - Transporters

    UR - http://www.scopus.com/inward/record.url?scp=84934435166&partnerID=8YFLogxK

    U2 - 10.1002/mnfr.201400745

    DO - 10.1002/mnfr.201400745

    M3 - Review Article

    C2 - 25988374

    AN - SCOPUS:84934435166

    VL - 59

    SP - 1307

    EP - 1323

    JO - Molecular Nutrition and Food Research

    JF - Molecular Nutrition and Food Research

    SN - 1613-4125

    IS - 7

    ER -