Mitosis as an anti-cancer drug target

Anne-Leena Salmela, Marko Kallio (Corresponding Author)

Research output: Contribution to journalArticleScientificpeer-review

40 Citations (Scopus)

Abstract

Suppression of cell proliferation by targeting mitosis is one potential cancer intervention. A number of existing chemotherapy drugs disrupt mitosis by targeting microtubule dynamics. While efficacious, these drugs have limitations, i.e. neuropathy, unpredictability and development of resistance. In order to overcome these issues, a great deal of effort has been spent exploring novel mitotic targets including Polo-like kinase 1, Aurora kinases, Mps1, Cenp-E and KSP/Eg5. Here we summarize the latest developments in the discovery and clinical evaluation of new mitotic drug targets.
Original languageEnglish
Pages (from-to)431-449
JournalChromosoma
Volume122
Issue number5
DOIs
Publication statusPublished - 2013
MoE publication typeA1 Journal article-refereed

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Keywords

  • anti-mitotics
  • cancer
  • drug development
  • LMW inhibitors
  • mitosis

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