Mixing and transport during pharmaceutical twin-screw wet granulation

Experimental analysis via chemical imaging

Ashish Kumar, Jurgen Vercruysse, Maunu Toiviainen, Pierre-Emmanuel Panouillot, Mikko Juuti, Valérie Vanhoorne, Chris Vervaet, Jean Paul Remon, Krist V. Gernaey, Thomas de Beer, Ingmar Nopens (Corresponding Author)

Research output: Contribution to journalArticleScientificpeer-review

55 Citations (Scopus)

Abstract

Twin-screw granulation is a promising continuous alternative for traditional batch high shear wet granulation (HSWG). The extent of HSWG in a twin screw granulator (TSG) is greatly governed by the residence time of the granulation materials in the TSG and degree of mixing. In order to determine the residence time distribution (RTD) and mixing in TSG, mostly visual observation and particle tracking methods are used, which are either inaccurate and difficult for short RTD, or provide an RTD only for a finite number of preferential tracer paths. In this study, near infrared chemical imaging, which is more accurate and provides a complete RTD, was used. The impact of changes in material throughput (10-17 kg/h), screw speed (500-900 rpm), number of kneading discs (2-12) and stagger angle (30-90°) on the RTD and axial mixing of the material was characterised. The experimental RTD curves were used to calculate the mean residence time, mean centred variance and the Péclet number to determine the axial mixing and predominance of convective over dispersive transport. The results showed that screw speed is the most influential parameter in terms of RTD and axial mixing in the TSG and established a significant interaction between screw design parameters (number and stagger angle of kneading discs) and the process parameters (material throughput and number of kneading discs). The results of the study will allow the development and validation of a transport model capable of predicting the RTD and macro-mixing in the TSG. These can later be coupled with a population balance model in order to predict granulation yields in a TSG more accurately
Original languageEnglish
Pages (from-to)279-289
JournalEuropean Journal of Pharmaceutics and Biopharmaceutics
Volume87
Issue number2
DOIs
Publication statusPublished - 2014
MoE publication typeA1 Journal article-refereed

Fingerprint

Pharmaceutical Preparations
Observation
Population

Keywords

  • Axial mixing
  • flow regime
  • NIR chemical imaging
  • residence time distribution
  • screw configuration
  • twin-screw granulation

Cite this

Kumar, Ashish ; Vercruysse, Jurgen ; Toiviainen, Maunu ; Panouillot, Pierre-Emmanuel ; Juuti, Mikko ; Vanhoorne, Valérie ; Vervaet, Chris ; Remon, Jean Paul ; Gernaey, Krist V. ; de Beer, Thomas ; Nopens, Ingmar. / Mixing and transport during pharmaceutical twin-screw wet granulation : Experimental analysis via chemical imaging. In: European Journal of Pharmaceutics and Biopharmaceutics. 2014 ; Vol. 87, No. 2. pp. 279-289.
@article{c053e3d6a08c49a2900a55f4a3cedc31,
title = "Mixing and transport during pharmaceutical twin-screw wet granulation: Experimental analysis via chemical imaging",
abstract = "Twin-screw granulation is a promising continuous alternative for traditional batch high shear wet granulation (HSWG). The extent of HSWG in a twin screw granulator (TSG) is greatly governed by the residence time of the granulation materials in the TSG and degree of mixing. In order to determine the residence time distribution (RTD) and mixing in TSG, mostly visual observation and particle tracking methods are used, which are either inaccurate and difficult for short RTD, or provide an RTD only for a finite number of preferential tracer paths. In this study, near infrared chemical imaging, which is more accurate and provides a complete RTD, was used. The impact of changes in material throughput (10-17 kg/h), screw speed (500-900 rpm), number of kneading discs (2-12) and stagger angle (30-90°) on the RTD and axial mixing of the material was characterised. The experimental RTD curves were used to calculate the mean residence time, mean centred variance and the P{\'e}clet number to determine the axial mixing and predominance of convective over dispersive transport. The results showed that screw speed is the most influential parameter in terms of RTD and axial mixing in the TSG and established a significant interaction between screw design parameters (number and stagger angle of kneading discs) and the process parameters (material throughput and number of kneading discs). The results of the study will allow the development and validation of a transport model capable of predicting the RTD and macro-mixing in the TSG. These can later be coupled with a population balance model in order to predict granulation yields in a TSG more accurately",
keywords = "Axial mixing, flow regime, NIR chemical imaging, residence time distribution, screw configuration, twin-screw granulation",
author = "Ashish Kumar and Jurgen Vercruysse and Maunu Toiviainen and Pierre-Emmanuel Panouillot and Mikko Juuti and Val{\'e}rie Vanhoorne and Chris Vervaet and Remon, {Jean Paul} and Gernaey, {Krist V.} and {de Beer}, Thomas and Ingmar Nopens",
year = "2014",
doi = "10.1016/j.ejpb.2014.04.004",
language = "English",
volume = "87",
pages = "279--289",
journal = "European Journal of Pharmaceutics and Biopharmaceutics",
issn = "0939-6411",
publisher = "Elsevier",
number = "2",

}

Kumar, A, Vercruysse, J, Toiviainen, M, Panouillot, P-E, Juuti, M, Vanhoorne, V, Vervaet, C, Remon, JP, Gernaey, KV, de Beer, T & Nopens, I 2014, 'Mixing and transport during pharmaceutical twin-screw wet granulation: Experimental analysis via chemical imaging', European Journal of Pharmaceutics and Biopharmaceutics, vol. 87, no. 2, pp. 279-289. https://doi.org/10.1016/j.ejpb.2014.04.004

Mixing and transport during pharmaceutical twin-screw wet granulation : Experimental analysis via chemical imaging. / Kumar, Ashish; Vercruysse, Jurgen; Toiviainen, Maunu; Panouillot, Pierre-Emmanuel; Juuti, Mikko; Vanhoorne, Valérie; Vervaet, Chris; Remon, Jean Paul; Gernaey, Krist V.; de Beer, Thomas; Nopens, Ingmar (Corresponding Author).

In: European Journal of Pharmaceutics and Biopharmaceutics, Vol. 87, No. 2, 2014, p. 279-289.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Mixing and transport during pharmaceutical twin-screw wet granulation

T2 - Experimental analysis via chemical imaging

AU - Kumar, Ashish

AU - Vercruysse, Jurgen

AU - Toiviainen, Maunu

AU - Panouillot, Pierre-Emmanuel

AU - Juuti, Mikko

AU - Vanhoorne, Valérie

AU - Vervaet, Chris

AU - Remon, Jean Paul

AU - Gernaey, Krist V.

AU - de Beer, Thomas

AU - Nopens, Ingmar

PY - 2014

Y1 - 2014

N2 - Twin-screw granulation is a promising continuous alternative for traditional batch high shear wet granulation (HSWG). The extent of HSWG in a twin screw granulator (TSG) is greatly governed by the residence time of the granulation materials in the TSG and degree of mixing. In order to determine the residence time distribution (RTD) and mixing in TSG, mostly visual observation and particle tracking methods are used, which are either inaccurate and difficult for short RTD, or provide an RTD only for a finite number of preferential tracer paths. In this study, near infrared chemical imaging, which is more accurate and provides a complete RTD, was used. The impact of changes in material throughput (10-17 kg/h), screw speed (500-900 rpm), number of kneading discs (2-12) and stagger angle (30-90°) on the RTD and axial mixing of the material was characterised. The experimental RTD curves were used to calculate the mean residence time, mean centred variance and the Péclet number to determine the axial mixing and predominance of convective over dispersive transport. The results showed that screw speed is the most influential parameter in terms of RTD and axial mixing in the TSG and established a significant interaction between screw design parameters (number and stagger angle of kneading discs) and the process parameters (material throughput and number of kneading discs). The results of the study will allow the development and validation of a transport model capable of predicting the RTD and macro-mixing in the TSG. These can later be coupled with a population balance model in order to predict granulation yields in a TSG more accurately

AB - Twin-screw granulation is a promising continuous alternative for traditional batch high shear wet granulation (HSWG). The extent of HSWG in a twin screw granulator (TSG) is greatly governed by the residence time of the granulation materials in the TSG and degree of mixing. In order to determine the residence time distribution (RTD) and mixing in TSG, mostly visual observation and particle tracking methods are used, which are either inaccurate and difficult for short RTD, or provide an RTD only for a finite number of preferential tracer paths. In this study, near infrared chemical imaging, which is more accurate and provides a complete RTD, was used. The impact of changes in material throughput (10-17 kg/h), screw speed (500-900 rpm), number of kneading discs (2-12) and stagger angle (30-90°) on the RTD and axial mixing of the material was characterised. The experimental RTD curves were used to calculate the mean residence time, mean centred variance and the Péclet number to determine the axial mixing and predominance of convective over dispersive transport. The results showed that screw speed is the most influential parameter in terms of RTD and axial mixing in the TSG and established a significant interaction between screw design parameters (number and stagger angle of kneading discs) and the process parameters (material throughput and number of kneading discs). The results of the study will allow the development and validation of a transport model capable of predicting the RTD and macro-mixing in the TSG. These can later be coupled with a population balance model in order to predict granulation yields in a TSG more accurately

KW - Axial mixing

KW - flow regime

KW - NIR chemical imaging

KW - residence time distribution

KW - screw configuration

KW - twin-screw granulation

U2 - 10.1016/j.ejpb.2014.04.004

DO - 10.1016/j.ejpb.2014.04.004

M3 - Article

VL - 87

SP - 279

EP - 289

JO - European Journal of Pharmaceutics and Biopharmaceutics

JF - European Journal of Pharmaceutics and Biopharmaceutics

SN - 0939-6411

IS - 2

ER -