Mobile phone radiation and the developing brain: Behavioral and morphological effects in juvenile rats

Timo Kumlin (Corresponding Author), Henriikka Iivonen, Pasi Miettinen, Antti Juvonen, Thomas van Groen, Lauri Puranen, Risto Pitkäaho, Jukka Juutilainen, Heikki Tanila

Research output: Contribution to journalArticleScientificpeer-review

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Abstract

The increasing use of mobile phones by children and teenagers has raised concerns about their safety. Addressing such concerns is difficult, because no data are available on possible effects from long-term exposure to radiofrequency (RF) fields during the development of the nervous system. Possible morphological and functional changes were evaluated in the central nervous system of young male Wistar rats exposed to 900 MHz mobile phone signal for 2 h/day on 5 days/week. After 5 weeks of exposure at whole-body average specific energy absorption rates of 0.3 or 3.0 W/kg or sham exposure, six rats per group were examined histologically, and the remaining 18 rats per group were subjected to behavioral tests. No degenerative changes, dying neurons, or effects on the leakage of the blood-brain barrier were detected. No group differences were observed in the open-field test, plus maze test or acoustic startle response tests. In the water maze test, however, significantly improved learning (P = 0.012) and memory (P = 0.01) were detected in rats exposed to RF fields. The results do not indicate a serious threat to the developing brain from mobile phone radiation at intensities relevant to human exposure. However, the interesting finding of improved learning and memory warrants further studies.
Original languageEnglish
Pages (from-to)471-479
JournalRadiation Research
Volume168
Issue number4
DOIs
Publication statusPublished - 2007
MoE publication typeA1 Journal article-refereed

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Cell Phones
rats
brain
Radiation
Brain
Startle Reflex
radiation
Learning
learning
blood-brain barrier
Blood-Brain Barrier
nervous system
Acoustics
Nervous System
central nervous system
Wistar Rats
field tests
energy absorption
Central Nervous System
neurons

Cite this

Kumlin, T., Iivonen, H., Miettinen, P., Juvonen, A., van Groen, T., Puranen, L., ... Tanila, H. (2007). Mobile phone radiation and the developing brain: Behavioral and morphological effects in juvenile rats. Radiation Research, 168(4), 471-479. https://doi.org/10.1667/RR1002.1
Kumlin, Timo ; Iivonen, Henriikka ; Miettinen, Pasi ; Juvonen, Antti ; van Groen, Thomas ; Puranen, Lauri ; Pitkäaho, Risto ; Juutilainen, Jukka ; Tanila, Heikki. / Mobile phone radiation and the developing brain : Behavioral and morphological effects in juvenile rats. In: Radiation Research. 2007 ; Vol. 168, No. 4. pp. 471-479.
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abstract = "The increasing use of mobile phones by children and teenagers has raised concerns about their safety. Addressing such concerns is difficult, because no data are available on possible effects from long-term exposure to radiofrequency (RF) fields during the development of the nervous system. Possible morphological and functional changes were evaluated in the central nervous system of young male Wistar rats exposed to 900 MHz mobile phone signal for 2 h/day on 5 days/week. After 5 weeks of exposure at whole-body average specific energy absorption rates of 0.3 or 3.0 W/kg or sham exposure, six rats per group were examined histologically, and the remaining 18 rats per group were subjected to behavioral tests. No degenerative changes, dying neurons, or effects on the leakage of the blood-brain barrier were detected. No group differences were observed in the open-field test, plus maze test or acoustic startle response tests. In the water maze test, however, significantly improved learning (P = 0.012) and memory (P = 0.01) were detected in rats exposed to RF fields. The results do not indicate a serious threat to the developing brain from mobile phone radiation at intensities relevant to human exposure. However, the interesting finding of improved learning and memory warrants further studies.",
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Kumlin, T, Iivonen, H, Miettinen, P, Juvonen, A, van Groen, T, Puranen, L, Pitkäaho, R, Juutilainen, J & Tanila, H 2007, 'Mobile phone radiation and the developing brain: Behavioral and morphological effects in juvenile rats', Radiation Research, vol. 168, no. 4, pp. 471-479. https://doi.org/10.1667/RR1002.1

Mobile phone radiation and the developing brain : Behavioral and morphological effects in juvenile rats. / Kumlin, Timo (Corresponding Author); Iivonen, Henriikka; Miettinen, Pasi; Juvonen, Antti; van Groen, Thomas; Puranen, Lauri; Pitkäaho, Risto; Juutilainen, Jukka; Tanila, Heikki.

In: Radiation Research, Vol. 168, No. 4, 2007, p. 471-479.

Research output: Contribution to journalArticleScientificpeer-review

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T2 - Behavioral and morphological effects in juvenile rats

AU - Kumlin, Timo

AU - Iivonen, Henriikka

AU - Miettinen, Pasi

AU - Juvonen, Antti

AU - van Groen, Thomas

AU - Puranen, Lauri

AU - Pitkäaho, Risto

AU - Juutilainen, Jukka

AU - Tanila, Heikki

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PY - 2007

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N2 - The increasing use of mobile phones by children and teenagers has raised concerns about their safety. Addressing such concerns is difficult, because no data are available on possible effects from long-term exposure to radiofrequency (RF) fields during the development of the nervous system. Possible morphological and functional changes were evaluated in the central nervous system of young male Wistar rats exposed to 900 MHz mobile phone signal for 2 h/day on 5 days/week. After 5 weeks of exposure at whole-body average specific energy absorption rates of 0.3 or 3.0 W/kg or sham exposure, six rats per group were examined histologically, and the remaining 18 rats per group were subjected to behavioral tests. No degenerative changes, dying neurons, or effects on the leakage of the blood-brain barrier were detected. No group differences were observed in the open-field test, plus maze test or acoustic startle response tests. In the water maze test, however, significantly improved learning (P = 0.012) and memory (P = 0.01) were detected in rats exposed to RF fields. The results do not indicate a serious threat to the developing brain from mobile phone radiation at intensities relevant to human exposure. However, the interesting finding of improved learning and memory warrants further studies.

AB - The increasing use of mobile phones by children and teenagers has raised concerns about their safety. Addressing such concerns is difficult, because no data are available on possible effects from long-term exposure to radiofrequency (RF) fields during the development of the nervous system. Possible morphological and functional changes were evaluated in the central nervous system of young male Wistar rats exposed to 900 MHz mobile phone signal for 2 h/day on 5 days/week. After 5 weeks of exposure at whole-body average specific energy absorption rates of 0.3 or 3.0 W/kg or sham exposure, six rats per group were examined histologically, and the remaining 18 rats per group were subjected to behavioral tests. No degenerative changes, dying neurons, or effects on the leakage of the blood-brain barrier were detected. No group differences were observed in the open-field test, plus maze test or acoustic startle response tests. In the water maze test, however, significantly improved learning (P = 0.012) and memory (P = 0.01) were detected in rats exposed to RF fields. The results do not indicate a serious threat to the developing brain from mobile phone radiation at intensities relevant to human exposure. However, the interesting finding of improved learning and memory warrants further studies.

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