Modeling biochemical systems with constrained Gibbs energy minimization

Research output: Chapter in Book/Report/Conference proceedingChapter or book articleProfessional

Abstract

Rising costs of fossil resources and products based thereupon has launched a large-scale interest in processing green biomass into raw materials for the chemical industry. Environmental awareness and concern for the global community spur researchers towards seeking thermally efficient and minimally wasteful processes. Current and future biorefinery concepts will use microorganisms to convert lignocellulosic feeds into valuable platform chemicals. However, very few natural organisms produce the desired intermediates in suitable amounts for industrial scale production. The biochemical systems in metabolic engineering are rich in different types of chemical species, modestly reactive, and contain many distinct compartments. A novel method based on multicomponent multiphase Gibbs energy minimization with kinetic constraints and pertinent Legendre transforms has been developed to support thermodynamic modeling of biochemical systems.
Original languageEnglish
Title of host publicationAdvanced Gibbs Energy Methods for Functional Materials and Processes
Subtitle of host publicationChemSheet 1999-2009
Place of PublicationEspoo
PublisherVTT Technical Research Centre of Finland
Pages138-145
ISBN (Electronic)978-951-38-7331-8
ISBN (Print)978-951-38-7330-1
Publication statusPublished - 2009
MoE publication typeNot Eligible

Publication series

SeriesVTT Tiedotteita - Research Notes
Number2506
ISSN1235-0605

Fingerprint

Gibbs free energy
Metabolic engineering
Chemical industry
Microorganisms
Raw materials
Biomass
Thermodynamics
Kinetics
Processing
Costs

Cite this

Blomberg, P. (2009). Modeling biochemical systems with constrained Gibbs energy minimization. In Advanced Gibbs Energy Methods for Functional Materials and Processes: ChemSheet 1999-2009 (pp. 138-145). Espoo: VTT Technical Research Centre of Finland. VTT Tiedotteita - Research Notes, No. 2506
Blomberg, Peter. / Modeling biochemical systems with constrained Gibbs energy minimization. Advanced Gibbs Energy Methods for Functional Materials and Processes: ChemSheet 1999-2009. Espoo : VTT Technical Research Centre of Finland, 2009. pp. 138-145 (VTT Tiedotteita - Research Notes; No. 2506).
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Blomberg, P 2009, Modeling biochemical systems with constrained Gibbs energy minimization. in Advanced Gibbs Energy Methods for Functional Materials and Processes: ChemSheet 1999-2009. VTT Technical Research Centre of Finland, Espoo, VTT Tiedotteita - Research Notes, no. 2506, pp. 138-145.

Modeling biochemical systems with constrained Gibbs energy minimization. / Blomberg, Peter.

Advanced Gibbs Energy Methods for Functional Materials and Processes: ChemSheet 1999-2009. Espoo : VTT Technical Research Centre of Finland, 2009. p. 138-145 (VTT Tiedotteita - Research Notes; No. 2506).

Research output: Chapter in Book/Report/Conference proceedingChapter or book articleProfessional

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Blomberg P. Modeling biochemical systems with constrained Gibbs energy minimization. In Advanced Gibbs Energy Methods for Functional Materials and Processes: ChemSheet 1999-2009. Espoo: VTT Technical Research Centre of Finland. 2009. p. 138-145. (VTT Tiedotteita - Research Notes; No. 2506).