Abstract
Rising costs of fossil resources and products based
thereupon has launched a large-scale interest in
processing green biomass into raw materials for the
chemical industry. Environmental awareness and concern
for the global community spur researchers towards seeking
thermally efficient and minimally wasteful processes.
Current and future biorefinery concepts will use
microorganisms to convert lignocellulosic feeds into
valuable platform chemicals. However, very few natural
organisms produce the desired intermediates in suitable
amounts for industrial scale production. The biochemical
systems in metabolic engineering are rich in different
types of chemical species, modestly reactive, and contain
many distinct compartments. A novel method based on
multicomponent multiphase Gibbs energy minimization with
kinetic constraints and pertinent Legendre transforms has
been developed to support thermodynamic modeling of
biochemical systems.
| Original language | English |
|---|---|
| Title of host publication | Advanced Gibbs Energy Methods for Functional Materials and Processes |
| Subtitle of host publication | ChemSheet 1999-2009 |
| Place of Publication | Espoo |
| Publisher | VTT Technical Research Centre of Finland |
| Pages | 138-145 |
| ISBN (Electronic) | 978-951-38-7331-8 |
| ISBN (Print) | 978-951-38-7330-1 |
| Publication status | Published - 2009 |
| MoE publication type | Not Eligible |
Publication series
| Series | VTT Tiedotteita - Research Notes |
|---|---|
| Number | 2506 |
| ISSN | 1235-0605 |
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Cite this
Blomberg, P. (2009). Modeling biochemical systems with constrained Gibbs energy minimization. In Advanced Gibbs Energy Methods for Functional Materials and Processes: ChemSheet 1999-2009 (pp. 138-145). VTT Technical Research Centre of Finland. VTT Tiedotteita - Research Notes, No. 2506 http://www.vtt.fi/inf/pdf/tiedotteet/2009/T2506.pdf