Modelling of brain tissue substitutes for phantom materials in neutron capture therapy (NCT) dosimetry

Tiina Seppälä; Jyrki Vähätalo; Iiro Auterinen; Antti Kosunen; David Nigg; Floyd Wheeler; Sauli Savolainen

doi:10.1016/S0969-806X(98)00342-9

Modelling of brain tissue substitutes for phantom materials in neutron capture therapy (NCT) dosimetry

Tiina Seppälä, Jyrki Vähätalo, Iiro Auterinen, Antti Kosunen, David Nigg, Floyd Wheeler, Sauli Savolainen (Corresponding Author)

Research output: Contribution to journal › Article › Scientific › peer-review

15 Citations (Scopus)

Abstract

The aim of this study was to define the most suitable brain tissue phantom material for neutron capture therapy (NCT). The calculated distributions of the thermal neutron fluence and the fast neutron and γ dose in normal brain tissue defined by ICRU were compared to those in four brain tissue substitutes: water, PMMA and two normal brain tissue substitute liquids, A and B, defined by us. Liquid B is an excellent material to simulate the neutron and γ interactions in normal brain tissue and it can be considered for use in situations for which higher accuracy is required, although it may not be suitable for routine use. Water is a suitable brain tissue substitute for periodic epithermal beam calibration, for routine quality control and for intercomparison of beams in NCT dosimetry.

Original language	English
Pages (from-to)	239-246
Number of pages	8
Journal	Radiation Physics and Chemistry
Volume	55
Issue number	3
DOIs	https://doi.org/10.1016/S0969-806X(98)00342-9
Publication status	Published - 1999
MoE publication type	A1 Journal article-refereed

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Seppälä, T., Vähätalo, J., Auterinen, I., Kosunen, A., Nigg, D., Wheeler, F., & Savolainen, S. (1999). Modelling of brain tissue substitutes for phantom materials in neutron capture therapy (NCT) dosimetry. Radiation Physics and Chemistry, 55(3), 239-246. https://doi.org/10.1016/S0969-806X(98)00342-9

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abstract = "The aim of this study was to define the most suitable brain tissue phantom material for neutron capture therapy (NCT). The calculated distributions of the thermal neutron fluence and the fast neutron and γ dose in normal brain tissue defined by ICRU were compared to those in four brain tissue substitutes: water, PMMA and two normal brain tissue substitute liquids, A and B, defined by us. Liquid B is an excellent material to simulate the neutron and γ interactions in normal brain tissue and it can be considered for use in situations for which higher accuracy is required, although it may not be suitable for routine use. Water is a suitable brain tissue substitute for periodic epithermal beam calibration, for routine quality control and for intercomparison of beams in NCT dosimetry.",

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Modelling of brain tissue substitutes for phantom materials in neutron capture therapy (NCT) dosimetry. / Seppälä, Tiina; Vähätalo, Jyrki; Auterinen, Iiro; Kosunen, Antti; Nigg, David; Wheeler, Floyd; Savolainen, Sauli (Corresponding Author).

In: Radiation Physics and Chemistry, Vol. 55, No. 3, 1999, p. 239-246.

Research output: Contribution to journal › Article › Scientific › peer-review

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AU - Nigg, David

AU - Wheeler, Floyd

AU - Savolainen, Sauli

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AB - The aim of this study was to define the most suitable brain tissue phantom material for neutron capture therapy (NCT). The calculated distributions of the thermal neutron fluence and the fast neutron and γ dose in normal brain tissue defined by ICRU were compared to those in four brain tissue substitutes: water, PMMA and two normal brain tissue substitute liquids, A and B, defined by us. Liquid B is an excellent material to simulate the neutron and γ interactions in normal brain tissue and it can be considered for use in situations for which higher accuracy is required, although it may not be suitable for routine use. Water is a suitable brain tissue substitute for periodic epithermal beam calibration, for routine quality control and for intercomparison of beams in NCT dosimetry.

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