Modular synthesis of self-assembling Janus-dendrimers and facile preparation of drug-loaded dendrimersomes

Sami Nummelin, Markus Selin, Sacha Legrand, Jarmo Ropponen, Jani Seitsonen, Antti Nykänen, Jari Koivisto, Jouni Hirvonen, Mauri A. Kostiainen, Luis M. Bimbo

    Research output: Contribution to journalArticlepeer-review

    19 Citations (Scopus)

    Abstract

    Materials and methods aimed at the next generation of nanoscale carriers for drugs and other therapeutics are currently in great demand. Yet, creating these precise molecular arrangements in a feasible and straightforward manner represents a remarkable challenge. Herein we report a modular synthetic route for amphiphilic Janus-dendrimers via a copper-catalyzed click reaction (CuAAC) and a facile procedure, using simple injection, to obtain highly uniform dendrimersomes with efficient loading of the model drug compound propranolol. The resulting assemblies were analyzed by dynamic light scattering and cryogenic transmission electron microscopy revealing the formation of unilamellar and multilamellar dendrimersomes. The formation of a bilayer structure was confirmed using cryo-TEM and confocal microscopy visualization of an encapsulated solvatochromic dye (Nile Red). The dendrimersomes reported here are tunable in size, stable over time and display robust thermal stability in aqueous media. Our results expand the scope of dendrimer-based supramolecular colloidal systems and offer the means for one-step fabrication of drug-loaded dendrimersomes in the size range of 90-200 nm, ideal for biomedical applications.
    Original languageEnglish
    Pages (from-to)7189-7198
    Number of pages10
    JournalNanoscale
    Volume9
    Issue number21
    DOIs
    Publication statusPublished - 7 Jun 2017
    MoE publication typeA1 Journal article-refereed

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