Keyphrases
Molecular Mechanism
100%
Tumor Protein p53 (TP53)
100%
A549
100%
Epothilones
100%
Sagopilone
100%
Non-small Cell Lung Cancer Cells
100%
Paclitaxel
21%
A549 Cells
21%
Human Lung Cancer Cell Line
14%
CDKN1A
14%
High Concentration
7%
Mechanism of Action
7%
Cell Proliferation
7%
Phase Transition
7%
Spindle Assembly Checkpoint
7%
Microtubules
7%
Knockdown
7%
M Phase
7%
Induced Apoptosis
7%
Mitotic Arrest
7%
Concentration-dependent
7%
DNA Damage Response
7%
Tumor Model
7%
In Vivo Activity
7%
Non-overlapping
7%
Cyclin B1
7%
Downstream Effectors
7%
Cytoskeletal Organization
7%
BubR1
7%
Murine Double Minute 2 (MDM2)
7%
Transcriptional Targets
7%
Overlapping Sets
7%
Apoptosis Induction
7%
Strong Disturbance
7%
Apoptosis Resistance
7%
Resistance Mechanisms
7%
Human Tumors
7%
Differential Mechanism
7%
Nanomolar Concentrations
7%
GADD45A
7%
INIS
concentration
100%
sensitivity
100%
lung cells
100%
cancer
100%
genes
71%
phenotype
57%
apoptosis
42%
induction
28%
in vitro
28%
comparative evaluations
14%
proliferation
14%
tumors
14%
range
14%
dna damages
14%
in vivo
14%
humans
14%
phase transformations
14%
disturbances
14%
microtubules
14%
cell proliferation
14%
Biochemistry, Genetics and Molecular Biology
Cancer Cell
100%
Epothilone
100%
Programmed Cell Death
100%
Spindle Checkpoint
33%
Upregulation
33%
Cell Proliferation
33%
Mitosis Inhibition
33%
Cell Cycle M Phase
33%
DNA Damage Response
33%
Cyclin B1
33%
Pharmacology, Toxicology and Pharmaceutical Science
Epothilone
100%
Sagopilone
100%
Non Small Cell Lung Cancer
100%
Paclitaxel
21%
Tumor Model
7%
Aneuploidy
7%
Cyclin B1
7%