Molecularly imprinted polymer on roll-to-roll printed electrodes as a single use sensor for monitoring of cortisol in sweat

Liam Gillan (Corresponding Author), Elina Jansson

Research output: Contribution to journalArticleScientificpeer-review

Abstract

Cortisol is involved in regulating many human physiological functions, with cortisol imbalance capable of causing adverse mental and physical health conditions. Existing tools for monitoring of cortisol can assist in alerting the need for mediation strategies, but these typically require time consuming processes such as sample preparation followed by laboratory analysis. This work demonstrates a miniature flexible sensor patch incorporating electrode structures produced by high throughput roll-to-roll rotary screen-printing process, which are subsequently functionalized by electropolymerization of a polypyrrole/Prussian blue molecularly imprinted polymer for measuring cortisol by chronoamperometry. The developed single use sensor patch provides acceptable selectivity for cortisol and operates in artificial eccrine perspiration across a broad concentration range of 0.1-10 000 ng ml-1 (R 2 = 0.916). In the application of measuring thermally induced sweat, the sensor provided results in agreement with the natural circadian rhythm of fluctuating cortisol.
Original languageEnglish
Article number025014
Number of pages11
JournalFlexible and Printed Electronics
Volume7
Issue number2
DOIs
Publication statusPublished - 1 Jun 2022
MoE publication typeA1 Journal article-refereed

Keywords

  • health monitoring
  • molecularly imprinted polymer
  • printed electronics
  • roll-to-roll printing
  • sweat cortisol
  • sweat sensor

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