Abstract
The pharmaceutical manufacturing platforms of fluid-bed
granulation and milling are widely used to modify
particle size. However, the adoption of process
analytical technology to monitor and control these
processes is difficult because of their dynamic nature.
This study examines the efficacy of a particle
characterizing technology to capture particle images
under dynamic conditions and to calculate particle size
distribution data both in-line and at-line during
fluid-bed granulation and milling.
| Original language | English |
|---|---|
| Pages (from-to) | 56-64 |
| Journal | Pharmaceutical Technology |
| Volume | 39 |
| Issue number | 3 |
| Publication status | Published - 2015 |
| MoE publication type | A1 Journal article-refereed |
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Cite this
Jones, I., Okkonen, M., Greene, A., & Cullen, P. J. (2015). Monitoring fluid-bed granulation and milling processes in-line with real-time imaging. Pharmaceutical Technology, 39(3), 56-64. http://www.pharmtech.com/monitoring-fluid-bed-granulation-and-milling-processes-line-real-time-imaging