Monitoring fluid-bed granulation and milling processes in-line with real-time imaging

I. Jones, Matti Okkonen, A. Greene, P.J. Cullen

Research output: Contribution to journal › Article › Scientific › peer-review

Abstract

The pharmaceutical manufacturing platforms of fluid-bed granulation and milling are widely used to modify particle size. However, the adoption of process analytical technology to monitor and control these processes is difficult because of their dynamic nature. This study examines the efficacy of a particle characterizing technology to capture particle images under dynamic conditions and to calculate particle size distribution data both in-line and at-line during fluid-bed granulation and milling.
Original languageEnglish
Pages (from-to)56-64
JournalPharmaceutical Technology
Volume39
Issue number3
Publication statusPublished - 2015
MoE publication typeA1 Journal article-refereed

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Particle Size
Technology
Pharmaceutical Preparations

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Jones, I. ; Okkonen, Matti ; Greene, A. ; Cullen, P.J. / Monitoring fluid-bed granulation and milling processes in-line with real-time imaging. In: Pharmaceutical Technology. 2015 ; Vol. 39, No. 3. pp. 56-64.
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Jones, I, Okkonen, M, Greene, A & Cullen, PJ 2015, 'Monitoring fluid-bed granulation and milling processes in-line with real-time imaging', Pharmaceutical Technology, vol. 39, no. 3, pp. 56-64.

Monitoring fluid-bed granulation and milling processes in-line with real-time imaging. / Jones, I.; Okkonen, Matti; Greene, A.; Cullen, P.J.

In: Pharmaceutical Technology, Vol. 39, No. 3, 2015, p. 56-64.

Research output: Contribution to journal › Article › Scientific › peer-review

TY - JOUR

T1 - Monitoring fluid-bed granulation and milling processes in-line with real-time imaging

AU - Jones, I.

AU - Okkonen, Matti

AU - Greene, A.

AU - Cullen, P.J.

PY - 2015

Y1 - 2015

N2 - The pharmaceutical manufacturing platforms of fluid-bed granulation and milling are widely used to modify particle size. However, the adoption of process analytical technology to monitor and control these processes is difficult because of their dynamic nature. This study examines the efficacy of a particle characterizing technology to capture particle images under dynamic conditions and to calculate particle size distribution data both in-line and at-line during fluid-bed granulation and milling.

AB - The pharmaceutical manufacturing platforms of fluid-bed granulation and milling are widely used to modify particle size. However, the adoption of process analytical technology to monitor and control these processes is difficult because of their dynamic nature. This study examines the efficacy of a particle characterizing technology to capture particle images under dynamic conditions and to calculate particle size distribution data both in-line and at-line during fluid-bed granulation and milling.

M3 - Article

VL - 39

SP - 56

EP - 64

JO - Pharmaceutical Technology

JF - Pharmaceutical Technology

SN - 1543-2521

IS - 3

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Jones I, Okkonen M, Greene A, Cullen PJ. Monitoring fluid-bed granulation and milling processes in-line with real-time imaging. Pharmaceutical Technology. 2015;39(3):56-64.

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