Monounsaturated fatty acids in serum triacylglycerols are associated with response to neoadjuvant chemotherapy in breast cancer patients

Mika Hilvo (Corresponding Author), S. Gade, Tuulia Hyötyläinen, V. Nekljudova, Tuulikki Seppänen-Laakso, Marko Sysi-Aho, M. Untch, J. Huober, G. von Minckwitz, C. Denkert, Matej Oresic, S. Loibl

Research output: Contribution to journalArticleScientificpeer-review

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Abstract

Changes in cellular lipid metabolism are a common feature in most solid tumors, which occur already in early stages of the tumor progression. However, it remains unclear if the tumor-specific lipid changes can be detected at the level of systemic lipid metabolism. The objective of this study was to perform comprehensive analysis of lipids in breast cancer patient serum samples. Lipidomic profiling using an established analytical platform was performed in two cohorts of breast cancer patients receiving neoadjuvant chemotherapy. The analyses were performed for 142 patients before and after neoadjuvant chemotherapy, and the results before chemotherapy were validated in an independent cohort of 194 patients. The analyses revealed that in general the tumor characteristics are not reflected in the serum samples. However, there was an association of specific triacylglycerols (TGs) in patients' response to chemotherapy. These TGs containing mainly oleic acid (C18:1) were found in lower levels in those patients showing pathologic complete response before receiving chemotherapy. Some of these TGs were also associated with estrogen receptor status and overall or disease-free survival of the patients. The results suggest that the altered serum levels of oleic acid in breast cancer patients are associated with their response to chemotherapy. What's new?: Up to 25% of breast tumors show pathologic complete response (pCR) following neoadjuvant chemotherapy. Identifying biomarkers that could predict pCR could help select those patients who would most benefit from therapy. Knowing that blood oleic acid concentration is increased in cancer patients and associated with breast cancer predisposition, here the authors explored how serum lipidomic profiles may be associated with pCR in patients receiving therapy. Lowered concentrations of oleic acid in serum triacylglycerols were found to be associated with pCR in breast cancer patients receiving neoadjuvant chemotherapy. This highlights the importance of systemic lipid metabolism status in response to chemotherapy.
Original languageEnglish
Pages (from-to)1725-1733
Number of pages9
JournalInternational Journal of Cancer
Volume134
Issue number7
DOIs
Publication statusPublished - 2014
MoE publication typeA1 Journal article-refereed

Fingerprint

Monounsaturated Fatty Acids
Triglycerides
Breast Neoplasms
Drug Therapy
Serum
Oleic Acid
Lipid Metabolism
Neoplasms
Lipids
Estrogen Receptors
Disease-Free Survival
Biomarkers

Keywords

  • breast cancer
  • lipidomics
  • oleic acid
  • pathologic complete response rate
  • stearoyl-CoA desaturase (SCD)

Cite this

Hilvo, Mika ; Gade, S. ; Hyötyläinen, Tuulia ; Nekljudova, V. ; Seppänen-Laakso, Tuulikki ; Sysi-Aho, Marko ; Untch, M. ; Huober, J. ; von Minckwitz, G. ; Denkert, C. ; Oresic, Matej ; Loibl, S. / Monounsaturated fatty acids in serum triacylglycerols are associated with response to neoadjuvant chemotherapy in breast cancer patients. In: International Journal of Cancer. 2014 ; Vol. 134, No. 7. pp. 1725-1733.
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title = "Monounsaturated fatty acids in serum triacylglycerols are associated with response to neoadjuvant chemotherapy in breast cancer patients",
abstract = "Changes in cellular lipid metabolism are a common feature in most solid tumors, which occur already in early stages of the tumor progression. However, it remains unclear if the tumor-specific lipid changes can be detected at the level of systemic lipid metabolism. The objective of this study was to perform comprehensive analysis of lipids in breast cancer patient serum samples. Lipidomic profiling using an established analytical platform was performed in two cohorts of breast cancer patients receiving neoadjuvant chemotherapy. The analyses were performed for 142 patients before and after neoadjuvant chemotherapy, and the results before chemotherapy were validated in an independent cohort of 194 patients. The analyses revealed that in general the tumor characteristics are not reflected in the serum samples. However, there was an association of specific triacylglycerols (TGs) in patients' response to chemotherapy. These TGs containing mainly oleic acid (C18:1) were found in lower levels in those patients showing pathologic complete response before receiving chemotherapy. Some of these TGs were also associated with estrogen receptor status and overall or disease-free survival of the patients. The results suggest that the altered serum levels of oleic acid in breast cancer patients are associated with their response to chemotherapy. What's new?: Up to 25{\%} of breast tumors show pathologic complete response (pCR) following neoadjuvant chemotherapy. Identifying biomarkers that could predict pCR could help select those patients who would most benefit from therapy. Knowing that blood oleic acid concentration is increased in cancer patients and associated with breast cancer predisposition, here the authors explored how serum lipidomic profiles may be associated with pCR in patients receiving therapy. Lowered concentrations of oleic acid in serum triacylglycerols were found to be associated with pCR in breast cancer patients receiving neoadjuvant chemotherapy. This highlights the importance of systemic lipid metabolism status in response to chemotherapy.",
keywords = "breast cancer, lipidomics, oleic acid, pathologic complete response rate, stearoyl-CoA desaturase (SCD)",
author = "Mika Hilvo and S. Gade and Tuulia Hy{\"o}tyl{\"a}inen and V. Nekljudova and Tuulikki Sepp{\"a}nen-Laakso and Marko Sysi-Aho and M. Untch and J. Huober and {von Minckwitz}, G. and C. Denkert and Matej Oresic and S. Loibl",
year = "2014",
doi = "10.1002/ijc.28491",
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Hilvo, M, Gade, S, Hyötyläinen, T, Nekljudova, V, Seppänen-Laakso, T, Sysi-Aho, M, Untch, M, Huober, J, von Minckwitz, G, Denkert, C, Oresic, M & Loibl, S 2014, 'Monounsaturated fatty acids in serum triacylglycerols are associated with response to neoadjuvant chemotherapy in breast cancer patients', International Journal of Cancer, vol. 134, no. 7, pp. 1725-1733. https://doi.org/10.1002/ijc.28491

Monounsaturated fatty acids in serum triacylglycerols are associated with response to neoadjuvant chemotherapy in breast cancer patients. / Hilvo, Mika (Corresponding Author); Gade, S.; Hyötyläinen, Tuulia; Nekljudova, V.; Seppänen-Laakso, Tuulikki; Sysi-Aho, Marko; Untch, M.; Huober, J.; von Minckwitz, G.; Denkert, C.; Oresic, Matej; Loibl, S.

In: International Journal of Cancer, Vol. 134, No. 7, 2014, p. 1725-1733.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Monounsaturated fatty acids in serum triacylglycerols are associated with response to neoadjuvant chemotherapy in breast cancer patients

AU - Hilvo, Mika

AU - Gade, S.

AU - Hyötyläinen, Tuulia

AU - Nekljudova, V.

AU - Seppänen-Laakso, Tuulikki

AU - Sysi-Aho, Marko

AU - Untch, M.

AU - Huober, J.

AU - von Minckwitz, G.

AU - Denkert, C.

AU - Oresic, Matej

AU - Loibl, S.

PY - 2014

Y1 - 2014

N2 - Changes in cellular lipid metabolism are a common feature in most solid tumors, which occur already in early stages of the tumor progression. However, it remains unclear if the tumor-specific lipid changes can be detected at the level of systemic lipid metabolism. The objective of this study was to perform comprehensive analysis of lipids in breast cancer patient serum samples. Lipidomic profiling using an established analytical platform was performed in two cohorts of breast cancer patients receiving neoadjuvant chemotherapy. The analyses were performed for 142 patients before and after neoadjuvant chemotherapy, and the results before chemotherapy were validated in an independent cohort of 194 patients. The analyses revealed that in general the tumor characteristics are not reflected in the serum samples. However, there was an association of specific triacylglycerols (TGs) in patients' response to chemotherapy. These TGs containing mainly oleic acid (C18:1) were found in lower levels in those patients showing pathologic complete response before receiving chemotherapy. Some of these TGs were also associated with estrogen receptor status and overall or disease-free survival of the patients. The results suggest that the altered serum levels of oleic acid in breast cancer patients are associated with their response to chemotherapy. What's new?: Up to 25% of breast tumors show pathologic complete response (pCR) following neoadjuvant chemotherapy. Identifying biomarkers that could predict pCR could help select those patients who would most benefit from therapy. Knowing that blood oleic acid concentration is increased in cancer patients and associated with breast cancer predisposition, here the authors explored how serum lipidomic profiles may be associated with pCR in patients receiving therapy. Lowered concentrations of oleic acid in serum triacylglycerols were found to be associated with pCR in breast cancer patients receiving neoadjuvant chemotherapy. This highlights the importance of systemic lipid metabolism status in response to chemotherapy.

AB - Changes in cellular lipid metabolism are a common feature in most solid tumors, which occur already in early stages of the tumor progression. However, it remains unclear if the tumor-specific lipid changes can be detected at the level of systemic lipid metabolism. The objective of this study was to perform comprehensive analysis of lipids in breast cancer patient serum samples. Lipidomic profiling using an established analytical platform was performed in two cohorts of breast cancer patients receiving neoadjuvant chemotherapy. The analyses were performed for 142 patients before and after neoadjuvant chemotherapy, and the results before chemotherapy were validated in an independent cohort of 194 patients. The analyses revealed that in general the tumor characteristics are not reflected in the serum samples. However, there was an association of specific triacylglycerols (TGs) in patients' response to chemotherapy. These TGs containing mainly oleic acid (C18:1) were found in lower levels in those patients showing pathologic complete response before receiving chemotherapy. Some of these TGs were also associated with estrogen receptor status and overall or disease-free survival of the patients. The results suggest that the altered serum levels of oleic acid in breast cancer patients are associated with their response to chemotherapy. What's new?: Up to 25% of breast tumors show pathologic complete response (pCR) following neoadjuvant chemotherapy. Identifying biomarkers that could predict pCR could help select those patients who would most benefit from therapy. Knowing that blood oleic acid concentration is increased in cancer patients and associated with breast cancer predisposition, here the authors explored how serum lipidomic profiles may be associated with pCR in patients receiving therapy. Lowered concentrations of oleic acid in serum triacylglycerols were found to be associated with pCR in breast cancer patients receiving neoadjuvant chemotherapy. This highlights the importance of systemic lipid metabolism status in response to chemotherapy.

KW - breast cancer

KW - lipidomics

KW - oleic acid

KW - pathologic complete response rate

KW - stearoyl-CoA desaturase (SCD)

U2 - 10.1002/ijc.28491

DO - 10.1002/ijc.28491

M3 - Article

VL - 134

SP - 1725

EP - 1733

JO - International Journal of Cancer

JF - International Journal of Cancer

SN - 0020-7136

IS - 7

ER -