Multivalent dendrons for high-affinity adhesion of proteins to DNA

Mauri A. Kostiainen (Corresponding Author), Geza Szilvay, David K. Smith (Corresponding Author), Markus Linder, Olli Ikkala

Research output: Contribution to journalArticleScientificpeer-review

62 Citations (Scopus)

Abstract

Strength in numbers: Multivalent dendrons that have an N‐maleimido group at the focal point can be used to construct monodisperse one‐to‐one protein–dendron conjugates. The second generation polyamine dendron with spermine surface groups clearly imparts its high‐affinity DNA binding to a protein of choice.
Original languageEnglish
Pages (from-to)3538-3542
Number of pages5
JournalAngewandte Chemie: International Edition
Volume45
Issue number21
DOIs
Publication statusPublished - 2006
MoE publication typeA1 Journal article-refereed

Keywords

  • dendrimers
  • DNA
  • multivalency
  • protein modifications
  • self-assembly

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