Multivalent dendrons for high-affinity adhesion of proteins to DNA

Mauri A. Kostiainen (Corresponding Author), Geza Szilvay, David K. Smith (Corresponding Author), Markus Linder, Olli Ikkala

Research output: Contribution to journalArticleScientificpeer-review

60 Citations (Scopus)

Abstract

Strength in numbers: Multivalent dendrons that have an N‐maleimido group at the focal point can be used to construct monodisperse one‐to‐one protein–dendron conjugates. The second generation polyamine dendron with spermine surface groups clearly imparts its high‐affinity DNA binding to a protein of choice.
Original languageEnglish
Pages (from-to)3538-3542
Number of pages5
JournalAngewandte Chemie: International Edition
Volume45
Issue number21
DOIs
Publication statusPublished - 2006
MoE publication typeA1 Journal article-refereed

Fingerprint

Dendrimers
Spermine
Polyamines
DNA
Adhesion
Proteins
dendron

Keywords

  • dendrimers
  • DNA
  • multivalency
  • protein modifications
  • self-assembly

Cite this

Kostiainen, Mauri A. ; Szilvay, Geza ; Smith, David K. ; Linder, Markus ; Ikkala, Olli. / Multivalent dendrons for high-affinity adhesion of proteins to DNA. In: Angewandte Chemie: International Edition. 2006 ; Vol. 45, No. 21. pp. 3538-3542.
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Multivalent dendrons for high-affinity adhesion of proteins to DNA. / Kostiainen, Mauri A. (Corresponding Author); Szilvay, Geza; Smith, David K. (Corresponding Author); Linder, Markus; Ikkala, Olli.

In: Angewandte Chemie: International Edition, Vol. 45, No. 21, 2006, p. 3538-3542.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Multivalent dendrons for high-affinity adhesion of proteins to DNA

AU - Kostiainen, Mauri A.

AU - Szilvay, Geza

AU - Smith, David K.

AU - Linder, Markus

AU - Ikkala, Olli

PY - 2006

Y1 - 2006

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AB - Strength in numbers: Multivalent dendrons that have an N‐maleimido group at the focal point can be used to construct monodisperse one‐to‐one protein–dendron conjugates. The second generation polyamine dendron with spermine surface groups clearly imparts its high‐affinity DNA binding to a protein of choice.

KW - dendrimers

KW - DNA

KW - multivalency

KW - protein modifications

KW - self-assembly

U2 - 10.1002/anie.200504540

DO - 10.1002/anie.200504540

M3 - Article

VL - 45

SP - 3538

EP - 3542

JO - Angewandte Chemie: International Edition

JF - Angewandte Chemie: International Edition

SN - 1433-7851

IS - 21

ER -