Multivalent dendrons for high-affinity adhesion of proteins to DNA

Mauri A. Kostiainen; Geza Szilvay; David K. Smith; Markus Linder; Olli Ikkala

doi:10.1002/anie.200504540

Multivalent dendrons for high-affinity adhesion of proteins to DNA

Mauri A. Kostiainen (Corresponding Author), Geza Szilvay, David K. Smith (Corresponding Author), Markus Linder, Olli Ikkala

Research output: Contribution to journal › Article › Scientific › peer-review

64 Citations (Scopus)

Abstract

Strength in numbers: Multivalent dendrons that have an N‐maleimido group at the focal point can be used to construct monodisperse one‐to‐one protein–dendron conjugates. The second generation polyamine dendron with spermine surface groups clearly imparts its high‐affinity DNA binding to a protein of choice.

Original language	English
Pages (from-to)	3538-3542
Number of pages	5
Journal	Angewandte Chemie: International Edition
Volume	45
Issue number	21
DOIs	https://doi.org/10.1002/anie.200504540
Publication status	Published - 2006
MoE publication type	A1 Journal article-refereed

Keywords

dendrimers
DNA
multivalency
protein modifications
self-assembly

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10.1002/anie.200504540

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title = "Multivalent dendrons for high-affinity adhesion of proteins to DNA",

abstract = "Strength in numbers: Multivalent dendrons that have an N‐maleimido group at the focal point can be used to construct monodisperse one‐to‐one protein–dendron conjugates. The second generation polyamine dendron with spermine surface groups clearly imparts its high‐affinity DNA binding to a protein of choice.",

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T1 - Multivalent dendrons for high-affinity adhesion of proteins to DNA

AU - Kostiainen, Mauri A.

AU - Szilvay, Geza

AU - Smith, David K.

AU - Linder, Markus

AU - Ikkala, Olli

PY - 2006

Y1 - 2006

N2 - Strength in numbers: Multivalent dendrons that have an N‐maleimido group at the focal point can be used to construct monodisperse one‐to‐one protein–dendron conjugates. The second generation polyamine dendron with spermine surface groups clearly imparts its high‐affinity DNA binding to a protein of choice.

AB - Strength in numbers: Multivalent dendrons that have an N‐maleimido group at the focal point can be used to construct monodisperse one‐to‐one protein–dendron conjugates. The second generation polyamine dendron with spermine surface groups clearly imparts its high‐affinity DNA binding to a protein of choice.

KW - dendrimers

KW - DNA

KW - multivalency

KW - protein modifications

KW - self-assembly

U2 - 10.1002/anie.200504540

DO - 10.1002/anie.200504540

M3 - Article

SN - 1433-7851

VL - 45

SP - 3538

EP - 3542

JO - Angewandte Chemie: International Edition

JF - Angewandte Chemie: International Edition

IS - 21

ER -

Multivalent dendrons for high-affinity adhesion of proteins to DNA

Abstract

Keywords

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