Abstract
Strength in numbers: Multivalent dendrons that have an N-maleimido group at the focal point can be used to construct monodisperse one-to-one protein-dendron conjugates. The second generation polyamine dendron with spermine surface groups clearly imparts its high-affinity DNA binding to a protein of choice.
| Original language | English |
|---|---|
| Pages (from-to) | 3538-3542 |
| Journal | Angewandte Chemie: International Edition |
| Volume | 45 |
| Issue number | 21 |
| DOIs | |
| Publication status | Published - 2006 |
| MoE publication type | A1 Journal article-refereed |
Funding
This work was supported by the Finnish National Graduate School in Nanoscience (M.A.K.), the Informational and structural biology graduate school (G.R.S.), and partly carried out in the Centre of Excellence of the Academy of Finnland (Bio- and Nanopolymers Research Group, 77317) and Academy of Finnland project 205997. The National Technology Agency of Finnland is acknowledged for project funding. The Finnish Chemical Society is gratefully acknowledged for a study grant. D.K.S acknowledges EPSRC for financial support (EP/C534395/1).
Keywords
- dendrimers
- DNA
- multivalency
- protein modifications
- self-assembly