Nanoparticles containing ketoprofen and acrylic polymers prepared by an aerosol flow reactor method

Hannele Eerikäinen, Leena Peltonen, Janne Raula, Jouni Hirvonen, Esko I. Kauppinen (Corresponding Author)

Research output: Contribution to journalArticleScientificpeer-review

26 Citations (Scopus)

Abstract

The purpose of this study was to outline the effects of interactions between a model drug and various acrylic polymers on the physical properties of nanoparticles prepared by an aerosol flow reactor method. The amount of model drug, ketoprofen, in the nanoparticles was varied, and the nanoparticles were analyzed for particle size distribution, particle morphology, thermal properties, IR spectroscopy, and drug release. The nanoparticles produced were spherical, amorphous, and had a matrix-type structure. Ketoprofen crystallization was observed when the amount of drug in Eudragit L nanoparticles was more than 33% (wt/wt). For Eudragit E and Eudragit RS nanoparticles, the drug acted as an effective plasticizer resulting in lowering of the glass transition of the polymer. Two factors affected the preparation of nanoparticles by the aerosol flow reactor method, namely, the solubility of the drug in the polymer matrix and the thermal properties of the resulting drug-polymer matrix.
Original languageEnglish
Article number68
Pages (from-to)129-137
Number of pages9
JournalAAPS PharmSciTech
Volume5
Issue number4
DOIs
Publication statusPublished - 2004
MoE publication typeA1 Journal article-refereed

Fingerprint

ketoprofen
Ketoprofen
nanoparticles
aerosols
Aerosols
Nanoparticles
polymers
Polymers
drugs
Pharmaceutical Preparations
thermal properties
methodology
Hot Temperature
Plasticizers
glass transition
plasticizers
infrared spectroscopy
particle size distribution
crystallization
Crystallization

Cite this

Eerikäinen, H., Peltonen, L., Raula, J., Hirvonen, J., & Kauppinen, E. I. (2004). Nanoparticles containing ketoprofen and acrylic polymers prepared by an aerosol flow reactor method. AAPS PharmSciTech, 5(4), 129-137. [68]. https://doi.org/10.1208/pt050468
Eerikäinen, Hannele ; Peltonen, Leena ; Raula, Janne ; Hirvonen, Jouni ; Kauppinen, Esko I. / Nanoparticles containing ketoprofen and acrylic polymers prepared by an aerosol flow reactor method. In: AAPS PharmSciTech. 2004 ; Vol. 5, No. 4. pp. 129-137.
@article{5a5f46a57d4844ea822f4a0c90de6004,
title = "Nanoparticles containing ketoprofen and acrylic polymers prepared by an aerosol flow reactor method",
abstract = "The purpose of this study was to outline the effects of interactions between a model drug and various acrylic polymers on the physical properties of nanoparticles prepared by an aerosol flow reactor method. The amount of model drug, ketoprofen, in the nanoparticles was varied, and the nanoparticles were analyzed for particle size distribution, particle morphology, thermal properties, IR spectroscopy, and drug release. The nanoparticles produced were spherical, amorphous, and had a matrix-type structure. Ketoprofen crystallization was observed when the amount of drug in Eudragit L nanoparticles was more than 33{\%} (wt/wt). For Eudragit E and Eudragit RS nanoparticles, the drug acted as an effective plasticizer resulting in lowering of the glass transition of the polymer. Two factors affected the preparation of nanoparticles by the aerosol flow reactor method, namely, the solubility of the drug in the polymer matrix and the thermal properties of the resulting drug-polymer matrix.",
author = "Hannele Eerik{\"a}inen and Leena Peltonen and Janne Raula and Jouni Hirvonen and Kauppinen, {Esko I.}",
year = "2004",
doi = "10.1208/pt050468",
language = "English",
volume = "5",
pages = "129--137",
journal = "AAPS PharmSciTech",
issn = "1530-9932",
publisher = "American Association of Pharmaceutical Scientists",
number = "4",

}

Eerikäinen, H, Peltonen, L, Raula, J, Hirvonen, J & Kauppinen, EI 2004, 'Nanoparticles containing ketoprofen and acrylic polymers prepared by an aerosol flow reactor method', AAPS PharmSciTech, vol. 5, no. 4, 68, pp. 129-137. https://doi.org/10.1208/pt050468

Nanoparticles containing ketoprofen and acrylic polymers prepared by an aerosol flow reactor method. / Eerikäinen, Hannele; Peltonen, Leena; Raula, Janne; Hirvonen, Jouni; Kauppinen, Esko I. (Corresponding Author).

In: AAPS PharmSciTech, Vol. 5, No. 4, 68, 2004, p. 129-137.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Nanoparticles containing ketoprofen and acrylic polymers prepared by an aerosol flow reactor method

AU - Eerikäinen, Hannele

AU - Peltonen, Leena

AU - Raula, Janne

AU - Hirvonen, Jouni

AU - Kauppinen, Esko I.

PY - 2004

Y1 - 2004

N2 - The purpose of this study was to outline the effects of interactions between a model drug and various acrylic polymers on the physical properties of nanoparticles prepared by an aerosol flow reactor method. The amount of model drug, ketoprofen, in the nanoparticles was varied, and the nanoparticles were analyzed for particle size distribution, particle morphology, thermal properties, IR spectroscopy, and drug release. The nanoparticles produced were spherical, amorphous, and had a matrix-type structure. Ketoprofen crystallization was observed when the amount of drug in Eudragit L nanoparticles was more than 33% (wt/wt). For Eudragit E and Eudragit RS nanoparticles, the drug acted as an effective plasticizer resulting in lowering of the glass transition of the polymer. Two factors affected the preparation of nanoparticles by the aerosol flow reactor method, namely, the solubility of the drug in the polymer matrix and the thermal properties of the resulting drug-polymer matrix.

AB - The purpose of this study was to outline the effects of interactions between a model drug and various acrylic polymers on the physical properties of nanoparticles prepared by an aerosol flow reactor method. The amount of model drug, ketoprofen, in the nanoparticles was varied, and the nanoparticles were analyzed for particle size distribution, particle morphology, thermal properties, IR spectroscopy, and drug release. The nanoparticles produced were spherical, amorphous, and had a matrix-type structure. Ketoprofen crystallization was observed when the amount of drug in Eudragit L nanoparticles was more than 33% (wt/wt). For Eudragit E and Eudragit RS nanoparticles, the drug acted as an effective plasticizer resulting in lowering of the glass transition of the polymer. Two factors affected the preparation of nanoparticles by the aerosol flow reactor method, namely, the solubility of the drug in the polymer matrix and the thermal properties of the resulting drug-polymer matrix.

U2 - 10.1208/pt050468

DO - 10.1208/pt050468

M3 - Article

VL - 5

SP - 129

EP - 137

JO - AAPS PharmSciTech

JF - AAPS PharmSciTech

SN - 1530-9932

IS - 4

M1 - 68

ER -