Abstract
The purpose of this study was to outline the effects of interactions
between a model drug and various acrylic polymers on the physical
properties of nanoparticles prepared by an aerosol flow reactor method.
The amount of model drug, ketoprofen, in the nanoparticles was varied,
and the nanoparticles were analyzed for particle size distribution,
particle morphology, thermal properties, IR spectroscopy, and drug
release. The nanoparticles produced were spherical, amorphous, and had a
matrix-type structure. Ketoprofen crystallization was observed when the
amount of drug in Eudragit L nanoparticles was more than 33% (wt/wt).
For Eudragit E and Eudragit RS nanoparticles, the drug acted as an
effective plasticizer resulting in lowering of the glass transition of
the polymer. Two factors affected the preparation of nanoparticles by
the aerosol flow reactor method, namely, the solubility of the drug in
the polymer matrix and the thermal properties of the resulting
drug-polymer matrix.
Original language | English |
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Article number | 68 |
Pages (from-to) | 129-137 |
Journal | AAPS PharmSciTech |
Volume | 5 |
Issue number | 4 |
DOIs | |
Publication status | Published - 2004 |
MoE publication type | A1 Journal article-refereed |