Abstract
| Original language | English |
|---|---|
| Article number | 68 |
| Pages (from-to) | 129-137 |
| Number of pages | 9 |
| Journal | AAPS PharmSciTech |
| Volume | 5 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 2004 |
| MoE publication type | A1 Journal article-refereed |
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Nanoparticles containing ketoprofen and acrylic polymers prepared by an aerosol flow reactor method. / Eerikäinen, Hannele; Peltonen, Leena; Raula, Janne; Hirvonen, Jouni; Kauppinen, Esko I. (Corresponding Author).
In: AAPS PharmSciTech, Vol. 5, No. 4, 68, 2004, p. 129-137.Research output: Contribution to journal › Article › Scientific › peer-review
TY - JOUR
T1 - Nanoparticles containing ketoprofen and acrylic polymers prepared by an aerosol flow reactor method
AU - Eerikäinen, Hannele
AU - Peltonen, Leena
AU - Raula, Janne
AU - Hirvonen, Jouni
AU - Kauppinen, Esko I.
PY - 2004
Y1 - 2004
N2 - The purpose of this study was to outline the effects of interactions between a model drug and various acrylic polymers on the physical properties of nanoparticles prepared by an aerosol flow reactor method. The amount of model drug, ketoprofen, in the nanoparticles was varied, and the nanoparticles were analyzed for particle size distribution, particle morphology, thermal properties, IR spectroscopy, and drug release. The nanoparticles produced were spherical, amorphous, and had a matrix-type structure. Ketoprofen crystallization was observed when the amount of drug in Eudragit L nanoparticles was more than 33% (wt/wt). For Eudragit E and Eudragit RS nanoparticles, the drug acted as an effective plasticizer resulting in lowering of the glass transition of the polymer. Two factors affected the preparation of nanoparticles by the aerosol flow reactor method, namely, the solubility of the drug in the polymer matrix and the thermal properties of the resulting drug-polymer matrix.
AB - The purpose of this study was to outline the effects of interactions between a model drug and various acrylic polymers on the physical properties of nanoparticles prepared by an aerosol flow reactor method. The amount of model drug, ketoprofen, in the nanoparticles was varied, and the nanoparticles were analyzed for particle size distribution, particle morphology, thermal properties, IR spectroscopy, and drug release. The nanoparticles produced were spherical, amorphous, and had a matrix-type structure. Ketoprofen crystallization was observed when the amount of drug in Eudragit L nanoparticles was more than 33% (wt/wt). For Eudragit E and Eudragit RS nanoparticles, the drug acted as an effective plasticizer resulting in lowering of the glass transition of the polymer. Two factors affected the preparation of nanoparticles by the aerosol flow reactor method, namely, the solubility of the drug in the polymer matrix and the thermal properties of the resulting drug-polymer matrix.
U2 - 10.1208/pt050468
DO - 10.1208/pt050468
M3 - Article
VL - 5
SP - 129
EP - 137
JO - AAPS PharmSciTech
JF - AAPS PharmSciTech
SN - 1530-9932
IS - 4
M1 - 68
ER -