Nature and nurture: Confluence of pathway determinism with metabolic and chemical serendipity diversifies: Monascus azaphilone pigments

Wanping Chen, Yanli Feng, István Molnár (Corresponding Author), Fusheng Chen (Corresponding Author)

Research output: Contribution to journalReview ArticleScientificpeer-review

53 Citations (Scopus)

Abstract

Covering: up to June 2018 Understanding the biosynthetic mechanisms that generate the astounding structural complexity and variety of fungal secondary metabolites (FSMs) remains a challenge. As an example, the biogenesis of the Monascus azaphilone pigments (MonAzPs) has remained obscure until recently despite the significant medical potential of these metabolites and their long history of widespread use as food colorants. However, a considerable progress has been made in recent years towards the elucidation of MonAzPs biosynthesis in various fungi. In this highlight, we correlate a unified biosynthetic pathway with the diverse structures of the 111 MonAzPs congeners reported until June 2018. We also discuss the origins of structural diversity amongst MonAzPs analogues and summarize new research directions towards exploring novel MonAzPs. The case of MonAzPs illuminates the various ways that FSMs metabolic complexity emerges by the interplay of biosynthetic pathway determinism with metabolic and chemical serendipity.

Original languageEnglish
Pages (from-to)561-572
Number of pages12
JournalNatural Product Reports
Volume36
Issue number4
DOIs
Publication statusPublished - 17 Apr 2019
MoE publication typeA2 Review article in a scientific journal

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