Negative regulators of integrin activity

Jeroen Pouwels, Jonna Nevo, Teijo Pellinen, Jari Ylänne, Johanna Ivaska

Research output: Contribution to journalArticleScientificpeer-review

28 Citations (Scopus)

Abstract

Integrins are heterodimeric transmembrane adhesion receptors composed of α- and β-subunits. They are ubiquitously expressed and have key roles in a number of important biological processes, such as development, maintenance of tissue homeostasis and immunological responses. The activity of integrins, which indicates their affinity towards their ligands, is tightly regulated such that signals inside the cell cruicially regulate the switching between active and inactive states. An impaired ability to activate integrins is associated with many human diseases, including bleeding disorders and immune deficiencies, whereas inappropriate integrin activation has been linked to inflammatory disorders and cancer. In recent years, the molecular details of integrin ‘inside-out’ activation have been actively investigated. Binding of cytoplasmic proteins, such as talins and kindlins, to the cytoplasmic tail of β-integrins is widely accepted as being the crucial step in integrin activation. By contrast, much less is known with regard to the counteracting mechanism involved in switching integrins into an inactive conformation. In this Commentary, we aim to discuss the known mechanisms of integrin inactivation and the molecules involved.
Original languageEnglish
Pages (from-to)3271-3280
JournalJournal of Cell Science
Volume125
Issue number14
DOIs
Publication statusPublished - 2012
MoE publication typeA1 Journal article-refereed

Keywords

  • Activation
  • adhesion
  • endocytosis
  • integrin
  • SHARPIN
  • talin

Fingerprint Dive into the research topics of 'Negative regulators of integrin activity'. Together they form a unique fingerprint.

Cite this